Single Nucleotide Variants Associated With Polygenic Hypercholesterolemia in Families Diagnosed Clinically With Familial Hypercholesterolemia

Conclusions Nonfamilial hypercholesterolemia genetic hypercholesterolemia families concentrate risk alleles for high LDL-C. Their contribution varies greatly among families, indicating the complexity and heterogeneity of these forms of hypercholesterolemias. The gene score explains a small percentage of LDL-C, which limits its use in diagnosis.
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research

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Publication date: 1 January 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 185Author(s): Yenisleidy de las Mercedes Zulueta Díaz, Karen Menghi, Maria Laura Guerrero, Natalia Nocelli, María Laura FananiAbstractL-ascorbic acid alkyl esters (ASCn) are lipophilic forms of vitamin C, which act as skin permeation enhancers. We investigated the physical changes induced by incorporating ASCn into stratum corneum (SC) lipid membranes and correlated this with the mechanism proposed in the literature for skin permeation enhancement phenomena. We used lipid monolayers to explore the 2D structure and elasticit...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01679A, PaperKyu Shik Eom, Yijae Lee, Hye Won Seo, Ji Yoon Kang, Joon S. Shim, Soo Hyun Lee An excessive cholesterol level can lead to cardiovascular diseases, such as stroke, hypertension, and myocardial infarction. A non-invasive, painless method of determining the cholesterol in the blood would improve the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
ConclusionsIn this high-risk low-income cohort, contributions of risk factors to HF varied, particularly by race. To reduce the population burden of HF, interventions tailored for specific race and sex groups may be warranted.Graphical abstract
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
BEST supplements for cholesterol: Having high cholesterol is a ticking time bomb due to it ’s major risk of potentially fatal complications. Thankfully, there are supplements one can take to help reduce their cholesterol levels and as such reduce their risk of serious medical conditions. What are the best supplements to take to help lower cholesterol?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Grobelna MK, Strauss E, Krasiński Z Abstract Lately there are many new, promising low-density lipoprotein cholesterol reducing therapies with PCSK9 inhibitors. We performed selected sampling of the publications in PubMed and made a review according to selected keywords. It summarizes the effect of PCSK9 on vascular aging, directly associated with lipid and glucose metabolism, chronic inflammation, atherosclerosis and hypertension. Serum level of PCSK9 is different in patients affected by certain illnesses (whose risk increases with age) than in healthy individuals. The same could be observed in the case of c...
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
Publication date: Available online 12 November 2019Source: Food BioscienceAuthor(s): Zhihui Yu, Ning Wang, Fang Geng, Meihu MaAbstractObesity induced by consuming a high-fat diet (HFD) is a major risk for nonalcoholic fatty liver disease, which has become a worldwide health problem. To study the effects of high-density lipoproteins of egg yolk (EYHDL) on mice with HFD induced obesity, lipidomic analyses using ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) was done with serum and liver samples on 60 and 100 days. The results showed that EYHDL significantly alleviated mouse obesity by decreasin...
Source: Food Bioscience - Category: Food Science Source Type: research
This study found a cross-sectional association between e-cigarette use and riskier lipoprotein (cholesterol) profiles. Based on that cross-sectional correlation, the investigators conclude that e-cigarette use leads to higher " bad " cholesterol levels and therefore, switching from smoking to vaping does not improve cardiovascular health.But let's examine this more closely.In a cross-sectional study, you have to be very careful in extrapolating from correlation to causation because this type of study design is very susceptible to confounding -- that is, a third variable that is associated with both smoking/vaping...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
Publication date: Available online 11 November 2019Source: Fish &Shellfish ImmunologyAuthor(s): Arya Vazirzadeh, Hasan Roosta, Hajar Masoumi, Ahmad Farhadi, Andrew JeffsAbstractThe long-term effects of three dietary probiotics on rainbow trout during grow-out (mean body weight = 250 ± 50g) were investigated by feeding for 130 days on eight diet treatments supplemented with Lactobacillus buchneri, L. fermentum and Saccharomyces cerevisiae at 107 CFU/g, singularly or in combination. Fish samples were taken for biochemical and immunological analysis in addition to growth performance indices at days 30 and...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In this study, we developed a simple strategy for directly detecting serum non-HDL-cholesterol based on magnetic core/functionalized antibody against apolipoprotein AI (anti-apoAI) materials. Anti-apoAI was successfully achieved oriented immobilization on the surface of superparamagnetic nanoparticles. The magnetic nanoparticles functionalized with immobilized anti-apoAI had a clear three-dimensional core-shell structure with an average diameter of about 750 nm and a high saturation magnetization. These nanoparticles rapidly captured HDL in serum, and the complex could be separated from the solution by application of an ex...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
TUESDAY, Nov. 12, 2019 -- Implementation of guidelines for lipid management in 2013 correlated with a reduction in mean total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C) levels, according to research published in the...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
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