Statistical vigilantes: the war on scientific fraud – Science Weekly podcast
Hannah Devlin delves into the case of a shamed Japanese scientist to explore how statistical malpractice is damaging science - whether employed knowingly or notSubscribe&Review oniTunes,Soundcloud,Audioboom,Mixcloud&Acast, and join the discussion onFacebook andTwitterOn paper, the Japanese anaesthesiologist Yoshitaka Fujii was a dazzling model of scientific productivity. Over two decades, he held posts at five institutions, associate positions at two more, and published more than 200 papers. In some years, he published a dozen randomised control trials – and it was this superhuman publication record that started to arouse suspicion among some of his colleagues. But it was only when a British doctor began scouring through the statistics in his papers that the phenomenal scale of Fujii’s scientific fraud became clear.Continue reading...
The anesthetic ketamine has shown promise as a rapid treatment for reducing suicidal thoughts in people with depression, a new study reveals.
The effectiveness of endovascular treatment in patients with anterior circulation ischaemic stroke due to large artery occlusion is firmly established, although optimal anaesthesia for the procedure remains contentious. Studies have suggested that endovascular treatment under general anaesthesia (GA) is associated with a worse outcome than when treatment is done without GA. However, because patients with more severe stroke and comorbidities are more likely to receive GA, there is potential for confounding by indication.
Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons.
Publication date: Available online 9 December 2017 Source:Trends in Anaesthesia and Critical Care Author(s): Benjamin H. Millette, Vassilis Athanassoglou, Anil Patel High flow nasal oxygen (flow rates of 20–70 L/min) is a relatively new addition to the therapeutic armamentarium of the modern physician. It consists of warmed, humidified mixture of oxygen and air that is delivered at flow rates of typically 20–70 L/min via purpose-built nasal cannulae. This review will focus on important implications of high flow nasal oxygen therapy in adult anaesthesia. We review the development history and current e...
Conclusion General blade design seems to be more important for the performance of videolaryngoscopes than the presence of a tube-guiding channel.
Publication date: December 2017 Source:Trends in Anaesthesia and Critical Care, Volume 17 Author(s): Arnd Timmermann, Iljaz Hodzovic, Robert T. Greif
Conclusions Early weaning of non-anesthetic AEDs does not increase the risk of recurrent seizures in patients treated for NCS or NCSE during their hospitalization.
ConclusionTIVA with a 1:10 ratio of ketofol admixture with a 90% reduction of McFarlan regimen can provide improved recovery conditions.Trial registrationClinicalTrials.gov identifier: NCT02848963.
Publication date: Available online 6 December 2017 Source:Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Author(s): Eri Uchikawa, Michiko Yoshizawa, Akinori Funayama, Toshihiko Mikami, Tadaharu Kobayashi Double lip is a rare anomaly characterized by hyperplastic mucosal tissue. It may occur either congenital or acquired. Surgical treatment, carried out under either local or general anesthesia, is indicated for cosmetic reasons and produces good functional and cosmetic results. Several surgical methods have been used, such as transverse elliptical excision, W-plasty, electrosurgical excision. Post-opera...