1H magnetic resonance spectroscopy suggests neural membrane alteration in specific regions involved in obsessive-compulsive disorder

Obsessive Compulsive Disorder (OCD) is the fourth most common psychiatric disorder, after phobias, addiction to alcohol and drugs, and depressive disorders, with prevalence between 1.2 to 2.4% (Karno M et al., 1988; Robins et al., 1985; Ruscio et al., 2010). Recommended first-line treatment is based on cognitive behavioural therapy (CBT) combined with antidepressant treatments (primarily Serotonin Reuptake Inhibitors SRI antidepressants). However, 40 to 60% of OCD patients exhibit drug resistance, leaving them with a major handicap in everyday life (Jaafari et al., 2011).
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research

Related Links:

BACKGROUND: It is aimed to determine the prevalence of suicidal behaviors regarding to epidemiological and psychosocial characteristics among Bruneian school-student adolescents. Methods: The cross-sectional study of 2599 (female: 49.9%; mean: 14.7 y...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Non-suicidal self-injury is a significant global public health problem during adolescence, nevertheless there is a lack of investigations among juvenile offenders. Our cross-sectional study aimed to investigate the relationship between negative life events...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Emotion dysregulation is implicated in both suicide attempts (SA) and non-suicidal self-injury (NSSI). However, little is known about how emotion dysregulation may differ between adolescents who have made an SA from those engaged in NSSI. We sought to addr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Based on attachment theory and a social-cognitive model of posttraumatic stress disorder (PTSD), this study examined the roles of parent-child communication, perceived parental depression, and intrusive rumination in the association between insecure attach...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Chronic pain is a complex experience that has now become a major public health issue. This has prompted many researchers to study attention, understanding it to be a crucial factor that allows altering the experience of pain, while attributing considerable...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
We report a case of attempted suicide by Cerbera odollam seed ingestion by a transgender patient who was successfully treated at our hospital. While the C. odollam plant has multiple practical and ornamental functions, its seeds have traditionally been uti...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
There are many gaps in scientific knowledge about the clinical significance of pharmacokinetic natural product-drug interactions (NPDIs) in which the NP is the precipitant and a conventional drug is the object. The National Center for Complimentary and Int...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Suicidal acts, both fatal and nonfatal, have increased in the United States over the past several years (1 –5), as have heavy drinking and alcohol use disorders (6–8), especially among women (7, 8), making the topic of the article by Edwards and col...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
OBJECTIVE: To study changes in the parameters of endogenous intoxication using the level of substances of low and medium molecular weight in the oral fluid in patients with catarrhal stomatitis, which got developed after the acute drug poisoning. MATER...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
The widespread use of opioids for the treatment of moderate or severe acute and chronic pain has become a public health problem due to the physical and psychological dependence and tolerance they produce. The increasingly higher doses that patients require...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
More News: Addiction | Alcoholism | Behavioural Therapy | Brain | Cognitive Behavior Therapy | Depression | Neurology | Obsessive Compulsive Disorder | Phobias | Psychiatry