1H magnetic resonance spectroscopy suggests neural membrane alteration in specific regions involved in obsessive-compulsive disorder

Obsessive Compulsive Disorder (OCD) is the fourth most common psychiatric disorder, after phobias, addiction to alcohol and drugs, and depressive disorders, with prevalence between 1.2 to 2.4% (Karno M et al., 1988; Robins et al., 1985; Ruscio et al., 2010). Recommended first-line treatment is based on cognitive behavioural therapy (CBT) combined with antidepressant treatments (primarily Serotonin Reuptake Inhibitors SRI antidepressants). However, 40 to 60% of OCD patients exhibit drug resistance, leaving them with a major handicap in everyday life (Jaafari et al., 2011).

Source: Psychiatry Research: Neuroimaging - September 13, 2017 Category: Psychiatry Authors: Laura Hatchondo, Nematollah Jaafari, Nicolas Langbour, Sylvie Maillochaud, Guillaume Herpe, R émy Guillevin, Carole Guillevin Source Type: research