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Emily Yurkins blighted by 'childhood Alzheimer's'

Six-year-old Emily Yurkins, of St Louis, Missouri, has Sanflippo Syndrome, also called 'childhood Alzheimer's.' It is a cruel, incurable genetic disease.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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ConclusionsThese results highlight the new concept that combined A β and tau thresholds can predict imminent neurodegeneration as an alternative framework with a high statistical power for testing the effect of disease-modifying therapies on [18F]FDG uptake decline over a typical 2-year clinical trial period in individuals with preclinical AD.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Publication date: Available online 23 April 2018 Source:Stem Cell Research Author(s): Michael Peitz, Tamara Bechler, Catrin Cornelia Thiele, Monika Veltel, Melanie Bloschies, Klaus Fliessbach, Alfredo Ramirez, Oliver Brüstle Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripo...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Conclusion: The factors associated with RCD were an MMSE score #x3c; 20 at treatment onset, female gender, psychotic symptoms, malnutrition, and a family history of dementia. These results may be directly relevant to patients, their families, and their physicians, enabling early anticipation of difficult clinical trajectories and poor functional outcomes.Dement Geriatr Cogn Disord 2018;45:1 –10
Source: Dementia and Geriatric Cognitive Disorders - Category: Geriatrics Source Type: research
One man has 'got his mum back' from the ravages of Alzheimer's, partly thanks to a change in her diet.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Notice NOT-HD-18-010 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
The toll from Alzheimer's is growing in this country with more than five million people suffering from the disease. On Sunday's "60 Minutes," Dr. Jon LaPook followed the personal story of Alzheimer's impact on one couple over the course of a decade. LaPook joins "CBS This Morning" to discuss his report.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
DEMENTIA signs and symptoms include memory loss, confusion and difficulty concentrating. But, you could lower your risk, or even prevent, Alzheimer ’s disease by eating a Mediterranean diet, scientists have claimed.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractBrain18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been utilized to monitor disease conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer ’s dementia (AD). However, the conversion patterns of FDG-PET metabolism across studies are not conclusive. We conducted a voxel-wise meta-analysis using Seed-basedd Mapping that included 10 baseline voxel-wise FDG-PET comparisons between 93 aMCI converters and 129 aMCI non-converters from nine longitudinal studies. The most robust and reliable metabolic alterations that predicted conversion from aMCI to AD were localized in the left pos...
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
Publication date: Available online 22 April 2018 Source:Pharmacological Research Author(s): Alessandra Caruso, Ferdinando Nicoletti, Dalila Mango, Amira Saidi, Rosamaria Orlando, Sergio Scaccianoce Prolonged stress predisposes susceptible individuals to a number of physiological disorders including cardiovascular disease, obesity and gastrointestinal disorders, as well as psychiatric and neurodegenerative disorders. Preclinical studies have suggested that manipulation of the glucocorticoid milieu can trigger cellular, molecular and behavioral derangement resembling the hallmarks of Alzheimer's Disease (AD). For example, s...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
AbstractThere are several theories regarding the etiologies of Alzheimer disease (AD). Considering that all genes responsible for familial AD are amyloid protein precursor (APP) or APP metabolizing enzymes, surely aberrant APP metabolism is crucial to pathogenesis of AD. BRI2, a type II transmembrane protein, binds APP and inhibits all α, β, and γ pathways of APP proteolysis. Crossing AD model mice with BRI2 transgenic or BRI2 knockout mice confirmed that BRI2 is an anti-Alzheimer gene. Mutations of BRI2 are known to cause rare familial dementias in human. Analysis of knock-in mice harboring the disease mu...
Source: Medical Molecular Morphology - Category: Molecular Biology Source Type: research
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