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Emily Yurkins blighted by 'childhood Alzheimer's'

Six-year-old Emily Yurkins, of St Louis, Missouri, has Sanflippo Syndrome, also called 'childhood Alzheimer's.' It is a cruel, incurable genetic disease.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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When the brain struggles to make sense of the world it may be less able to perform other important tasks.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Ears and Hearing Eyes and Eyesight Memory Alzheimer's Disease Brain Elderly Dementia Hearing Aids Source Type: news
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 144 Author(s): Tanya P. Garcia, Karen Marder, Yuanjia Wang Huntington disease (HD) is caused by a CAG trinucleotide expansion in the huntingtin gene. We now have the power to predict age-at-onset from subject-specific features like motor and neuroimaging measures. In clinical trials, properly modeling onset age is important, because it improves power calculations and directs clinicians to recruit subjects with certain features. The history of modeling onset, from simple linear and logistic regression to advanced survival models, is discussed. We highligh...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 144 Author(s): Fernando Pagan, Yasar Torres-Yaghi, Marcelle Altshuler Huntington disease (HD) is an autosomal-dominant disorder resulting from CAG triplet repeats, which leads to an expanded polyglutamine sequence in the HTT (Huntingtin) protein. Accumulation of the Huntingtin protein ultimately leads to neurodegeneration and negative effects in multiple clinical domains, including motor function, cognition, and behavior. HD is a disorder governed by genetics, and the ability to quantify the CAG triplet repeats can provide important insight regarding cli...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 144 Author(s): Julie C. Stout, Sophie C. Andrews, Yifat Glikmann-Johnston Several Huntington disease (HD) clinical trials are in progress and on the horizon. Potential treatments are increasingly being targeted at ameliorating the cognitive decline in HD. This necessitates a careful consideration of trial designs, including endpoint strategies suitable for testing cognitive function. The aim of this chapter is to evaluate and consider the use of cognitive measures in HD clinical trials. We first consider the role of cognition in clinical trial endpoint m...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
This article is protected by copyright. All rights reserved. New synthesized series of 9‐amino‐1,2,3,4‐tetrahydroacridine derivatives with iodobenzoic acid moiety were studied for their inhibitory activity towards cholinesterase and against β‐amyloid aggregation. All novel molecules interacted with both cholinesterases – acetylcholinesterase and butyrylcholinesterase, delivered nanomolar IC50 values. The structure‐activity relationship showed that N‐butyl moiety derivatives are stronger inhibitors towards AChE and BChE than N‐ethyl and N‐propyl moieties compounds.
Source: Chemical Biology and Drug Design - Category: Biology Authors: Tags: Research Article Source Type: research
Authors: Zhang W, Shi J, Yu J, Zhan L, Thompson PM, Wang Y Abstract In order to improve the preclinical diagnose of Alzheimer's disease (AD), there is a great deal of interest in analyzing the AD related brain structural changes with magnetic resonance image (MRI) analyses. As the major features, variation of the structural connectivity and the cortical surface morphometry provide different views of structural changes to determine whether AD is present on presymptomatic patients. However, the large scale tensor-valued information and relatively low imaging resolution in diffusion MRI (dMRI) have created huge challe...
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
At present there is no therapy for Alzheimer ’s Disease which completely stops the progressive dementia effecting late onset Alzheimer’s Disease (AD) patients. It is felt that the main reason for this failure is that AD appears to be a disease caused by four major pathological processes. To date, efforts to develop treatments have addresse d only one or another of these four etiologies. However, even a partially effective therapy against one cause allows the others, untreated, to continue their inexorable destruction of the neurons of the brain.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research
Dear Carol: My mom moved into the memory unit of an assisted living last year and she loves it. She’s very social so this environment is perfect for her. Now, my brother has suddenly decided that he wants Mom to come and stay with him for the winter since he lives in a warmer climate. He’s the man so he has the Power Of Attorney. Mom doesn’t want to leave her comfortable little apartment, but she’s said if he really wants her there for a time, she should do it. My fear is that the move could make her dementia worse. My brother says he just wants to spend more time with Mom, but he's n...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
In this study, we report the isolation of two natural coumarins, namely umbelliferone (1) and 6-formyl umbelliferone (2), from Angelica decursiva, and the synthesis of 8-formyl umbelliferone (3) from 1. We investigated the anti-Alzheimer disease (anti-AD) potential of these coumarins by assessing their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1). Among these coumarins, 2 exhibited poor inhibitory activity against AChE and BChE, and modest activity against BACE1. Structure–activity relationship analysis showed t...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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