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Pancreatic Enzyme Replacement in Chronic Pancreatitis Pancreatic Enzyme Replacement in Chronic Pancreatitis

Are there tangible benefits to pancreatic enzyme replacement therapy in chronic pancreatitis? For which patients might it be beneficial?Gut
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

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Authors: Scheen AJ Abstract INTRODUCTION: Dipeptidyl peptidase-4 inhibitors (DPP-4is) are generally considered as glucose-lowering agents with a safe profile in type 2 diabetes. Areas covered: An updated review of recent safety data from randomised controlled trials, observational studies, meta-analyses, pharmacovigilance reports regarding alogliptin, linagliptin, saxagliptin, sitagliptin, and vildagliptin, with a special focus on risks of hypoglycaemia, pancreatitis and pancreatic cancer, major cardiovascular events, hospitalisation for heart failure and other new safety issues, such as bone fractures and arthralg...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
The effect of ivacaftor in patients with cystic fibrosis (CF) with recurrent pancreatitis is unknown. We conducted a multicenter retrospective study of patients with CF taking ivacaftor who had a history of recurrent pancreatitis. During the first 3 months of therapy, only 1 of the 6 patients had an episode of pancreatitis, which was managed on an outpatient basis. Between 3 and 12 months on ivacaftor therapy, none of the patients had recurrence of pancreatitis or required hospitalization. The use of ivacaftor was associated with a reduced frequency and recurrence rate of pancreatitis in patients with CF.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Short Communication: Pancreatology Source Type: research
Conclusions:EUS diagnosed CP (≥4 features) in 31% and biliary abnormality in 3% children with ARP. EUS is safe, sensitive, and useful for early diagnosis of CP in children with ARP. Objectives: Endoscopic ultrasound (EUS) is an established tool for evaluation of adults with acute recurrent pancreatitis (ARP) whereas data in pediatrics is limited. Our study assessed the role of EUS in identifying etiology including changes of chronic pancreatitis (CP) in children and adolescents with ARP. Methods: Children with ARP (≥2 episodes of acute pancreatitis [AP]) were prospectively evaluated with a detailed clinical pr...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Pancreatology Source Type: research
Conclusions: Among critically ill patients with acute pancreatitis, mortality at 30 days was lower in patients who received epidural analgesia than in comparable patients who did not. These findings support ongoing research on the use of epidural analgesia as a therapeutic intervention in acute pancreatitis.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
(MedPage Today) -- Likelihood of pancreatic cancer increased beyond 5 years after the acute episode
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
AimTo assess long‐term safety and efficacy of stiripentol as an antiepileptic medication for people with Dravet syndrome. MethodA prospective, observational open‐label study (2003–2015) of the efficacy and long‐term safety of stiripentol in patients with Dravet syndrome and ongoing seizures. Frequency of generalized tonic‐clonic seizures, focal seizures, status epilepticus, and adverse events were recorded. ResultsForty‐one patients started stiripentol, with median age at enrolment 5 years 7 months (range 11mo–22y) and median duration of treatment 37 months (range 2–141mo). Twenty out of 41 pati...
Source: Developmental Medicine and Child Neurology - Category: Child Development Authors: Tags: Original Article Source Type: research
We report here for the first time a family from India that is positive for R122H mutation in thePRSS1 gene. The proband is symptomatic with chronic pancreatitis, however, the father although heterozygous for R122H is asymptomatic.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
We take a look at how diet can help with pancreatitis, including foods to eat and foods to avoid. We also examine diet tips and treatment options.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
ld The mouse pancreas adopts a pre-inflammatory state in response to a chemical injury or the loss of one copy of the gene Nr5a2. This state might predispose mice, and possibly humans, to pancreatitis and pancreatic cancer.
Source: Nature - Category: Research Authors: Tags: News & Views Source Type: research
AbstractA patient with slight dilatation of the main pancreatic duct was followed-up with ultrasonography every 6  months as a high-risk case of pancreatic cancer. Twelve years later, a faint hypoechoic area 13 mm in diameter was first detected on the body of the pancreas. Contrast-enhanced ultrasonography revealed a well-demarcated hypoenhanced area 8 mm in diameter and a hyperenhanced area with an unclear margin. The former was suspected to be a small pancreatic cancer lesion, and the latter to be focal pancreatitis accompanying cancer. However, contrast-enhanced dynamic CT did not suggest any tumor, diagn...
Source: Journal of Medical Ultrasonics - Category: Radiology Source Type: research
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