Surgeons play big role in women's choices for breast cancer care
A breast cancer patient's choice of surgeon can have a major effect on her treatment, according to a new study.
This study is the first of its kind to provide patient-reported outcomes about fat grafting, and reflects a growing trend of incorporating patient-reported outcomes into clinical trials. Gaining a better understanding of outcomes from the patients’ perspective helps researchers and clinicians to design and deliver care that truly meets the personal preferences and treatment priorities of women diagnosed with breast cancer. I’d like to thank my colleague Dr. Dhruv Singhal, a plastic surgeon at Beth Israel Deaconess Medical Center, for his contributions to this post. The post Revisiting options for imp...
FYN promotes mesenchymal phenotypes of basal type breast cancer cells through STAT5/NOTCH2 signaling node, Published online: 19 January 2018; doi:10.1038/s41388-017-0114-yFYN promotes mesenchymal phenotypes of basal type breast cancer cells through STAT5/NOTCH2 signaling node
Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore, Published online: 19 January 2018; doi:10.1038/s41388-017-0103-1Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore
Publication date: Available online 12 January 2018 Source:Chemico-Biological Interactions Author(s): Isabel Cristina da Costa Araldi, Fernando Primitivo Romero Bordin, Francine Carla Cadoná, Fernanda Barbisan, Verônica Farina Azzolin, Cibele Ferreira Teixeira, Tadeu Baumhardt, Ivana Beatrice Mânica da Cruz, Marta Maria Medeiros Frescura Duarte, Liliane de Freitas Bauermann Radiation therapy is commonly applied in breast cancer (BC) patients. However, radioresistance and side effects are limiting factors of this practice. Therefore, studying substances that can enhance the radiation effect and, at the sa...
Conclusions Combination treatment with lumretuzumab, pertuzumab and paclitaxel was associated with a high incidence of diarrhea. Despite the efforts to alter dosing, the therapeutic window remained too narrow to warrant further clinical development. Trial registration: onClinicalTrials.gov with the identifier NCT01918254 first registered on 3rd July 2013.
This article is protected by copyright. All rights reserved.
ConclusionsOne in three postmenopausal, HR+ BCS considered themselves to be living with chronic pain. Effective interventions to reduce chronic pain are needed.
AbstractPurpose of ReviewTo synthesize the critical role of obesity-associated inflammation, dietary factors, and nutrition in determining breast cancer risk.Recent FindingsObesity-associated inflammation is strongly linked to breast cancer risk and progression, largely via two processes: inflammatory pathways and dysregulated metabolism. Cytokine production in excess adipose tissues creates a chronic inflammatory microenvironment, which favors tumor development. Lifestyle factors, including diet, have long been recognized as important determinants of breast cancer risk and mortality.SummaryObesity increases the risk of de...