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Surgeons play big role in women's choices for breast cancer care

A breast cancer patient's choice of surgeon can have a major effect on her treatment, according to a new study.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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CONCLUSIONS: The BP regimen was active and well tolerated in the real-world clinical settings. As many as 28.9% of patients who received the initial dose of 90 mg/m(2) required a dose reduction of paclitaxel by 20 mg/m(2). Therefore, there is a need to find a therapeutic regimen that is less likely to result in dose reductions for patients with MBC who undergo a BP regimen using the initial paclitaxel dose of 90 mg/m(2). PMID: 29142182 [PubMed - in process]
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research
Survivorship Care Plans: Rural, Low-Income Breast Cancer Survivor Perspectives
. Clin J Oncol Nurs. 2017 Dec 01;21(6):692-698 Authors: DeGuzman P, Colliton K, Nail CJ, Keim-Malpass J Abstract BACKGROUND: Despite increasing implementation of survivorship care plans (SCPs), cancer survivors still experience unmet needs post-treatment. Rural, low-income survivors experience less planning for supportive care during treatment, which is difficult to overcome after patients complete treatment.
. OBJECTIVES: This pilot study explores post-
treatment survivorship care planning execution, perception,...
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
Curcumin inhibits MCF-7 cells by modulating the NF-κB signaling pathway. Oncol Lett. 2017 Nov;14(5):5581-5584 Authors: Liu JL, Pan YY, Chen O, Luan Y, Xue X, Zhao JJ, Liu L, Jia HY Abstract The present study investigated the inhibitory effect of curcumin on human breast cancer MCF-7 cells and investigated the potential underlying molecular mechanisms. MCF-7 cells were cultured with curcumin at different concentrations and time points. The effects of curcumin treatment on breast cancer cell proliferation were studied using a MTT assay. Reverse transcription-quantitative polymerase chain reaction a...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Arnold KM, Pohlig RT, Sims-Mourtada J Abstract Hedgehog (HH) and Wnt pathway activation have been implicated in poor prognosis of breast cancer. Crosstalk between these two pathways has been demonstrated to be important in breast cancer progression, however the association between these two pathways and breast cancer survival rate is unknown. The present study comprised a cohort of 36 patients with triple negative breast cancer (TNBC) to investigate co-activation of HH and canonical Wnt pathway in association to patient outcome. All patients had varying degrees of cytoplasmic sonic HH and glioma-associated...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Fan X, Chen W, Fu Z, Zeng L, Yin Y, Yuan H Abstract Cancer stem cells (CSCs; also known as tumor-initiating cells) are essential effectors of tumor progression due to their self-renewal capacity, differentiation potential, tumorigenic ability and resistance to chemotherapy, all of which contribute to cancer relapse, metastasis and a poor prognosis. Breast cancer stem cells (BCSCs) have been identified to be involved in the processes of BC initiation, growth and recurrence. MicroRNAs (miRNAs) are a class of non-coding small RNAs of 19-23 nucleotides in length that regulate gene expression at the post-transc...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Kang HJ, Yi YW, Hou SJ, Kim HJ, Kong Y, Bae I, Brown ML Abstract Epigenetic regulation of gene expression is an emerging target to treat several human diseases including cancers. In cancers, expressions of many tumor suppressor genes are suppressed by hyper-methylation in their regulatory regions. Herein, we describe a novel carbazole SH-I-14 that decreased the level of the acetyl-STAT3 at the K685 residue. Mutation analysis revealed that SH-I-14 disrupted STAT3-DNMT1 interaction by removing acetyl group from K685 of STAT3. Finally, the inhibition of STAT3-DNMT1 interaction by SH-I-14 resulted in re-expres...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
incione Patrizia Diana Tripentones represent an interesting class of compounds due to their significant cytotoxicity against different human tumor cells in the submicro-nanomolar range. New tripentone analogs, in which a pyridine moiety replaces the thiophene ring originating the fused azaindole system endowed with anticancer activity viz 8H-thieno[2,3-b]pyrrolizinones, were efficiently synthesized in four steps with fair overall yields (34–57%). All tripentone derivatives were tested in the range of 0.1–100 μM for cytotoxicity against two human tumor cell lines, HCT-116 (human colorectal carcinoma) an...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Abstract Calcium ions (Ca2+) act as second messengers in intracellular signaling. Ca2+ pumps, channels, sensors, and calcium binding proteins, regulate the concentrations of intracellular Ca2+ as a key regulator of important cellular processes such as gene expression, proliferation, differentiation, DNA repair, apoptosis, metastasis, and hormone secretion. Intracellular Ca2+ also influences the functions of several organelles, that include: the endoplasmic reticulum, mitochondria, the Golgi, and cell membrane both in normal and breast cancer cells. In breast cancer, the disruption of intracellular: Ca2+ homeostasis may cau...
Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: REVIEW ARTICLE Source Type: research
In this study, 152 subjects from two independent databases, one with analog- and one with digital mammograms, were used to validate the methodology. Areas under the receiver operating characteristic curve of 0.738 and 0.767, and diagnostic odds ratios of 23.10 and 9.00 were achieved, respectively. In addition, the proposed method has the potential to rank subjects by their probability of having breast cancer, aiding in the re-scheduling of the radiologists’ image queue, an issue of utmost importance in developing countries.
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Fat necrosis of the breast is a common benign entity with imaging features and clinical findings that can mimic breast cancer, requiring biopsy for diagnosis.1 Fat necrosis initially was described in 1920 as the result of blunt trauma to the breast. With the growing number of reduction mammoplasty procedures, radiation therapy, breast conserving procedures, and reconstructive surgical procedures, fat necrosis now is encountered frequently in daily radiology practice.1 Fat necrosis has widely varied presentations on breast imaging during its many stages of evolution.1 Hence, it is important for radiologists to be familiar w...
Source: Contemporary Diagnostic Radiology - Category: Radiology Tags: Article Source Type: research
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