HIV vaccine may be just a short step away
Researchers believe they have solved the problem by 'unblocking' a process linked to an HIV protein that was halting the production of antibody-generating 'B-cells' from the immune system.
Adriana Weinberg, Jane Lindsey, Ronald Bosch, Deborah Persaud, Paul Sato, Anthony Ogwu, Aida Asmelash, Mutsa Bwakura-Dangarambezi, Benjamin H. Chi, Jennifer Canniff, Shahin Lockman, Simani Gaseitsiwe, Sikhulile Moyo, Christiana Elizabeth Smith, Natasha O. Moraka, Myron J. Levin, for the P1072 and Tshipidi Study Teams , Charles Fane, Dudu Kooreng, Tebogo J. Kakhu, Loeto Mazhani, Tumalano Sekoto, Lesedi Tirelo, Tshepo T. Frank, Mpho Raesi, Grace Kinabo, Boniface Njau, Anne Buchanan, Janeth Kimaro, Felistus Mbewe, Ellen Shingalili, Fyatilani Chirwa, Helen Bwalya Mulenga, Tapiwa Mbengeranwa, Taurai Beta, Ethel Dauya, Hilda Mujuru
Vinay Menon, Melissa C. Kapulu, Iona Taylor, Kerry Jewell, Yuanyuan Li, Fergal Hill, Carole A. Long, Kazutoyo Miura, Sumi Biswas
Authors: Petrosillo N Abstract The pathogenesis of recurrent Clostridium difficile infection (CDI) is still poorly understood. The risk of recurrence is approximately 20% after an initial CDI episode and dramatically increases with subsequent CDI recurrences. Several factors may play a role in recurrent CDI (rCDI), including conditions influencing germination, metabolic pathways that influence toxin production of C. difficile, and the microbiota composition offering protection against colonization and disease caused by C. difficile. Paradoxically, the currently recommended treatment for acute symptomatic ...
More than 700,000 Americans were hospitalized due to illnesses associated with the seasonal flu during the 2014 –15 flu season, according to federal estimates. A radical new approach to vaccine development at UCLA may help lower that figure for future flu seasons.The scientists used leading-edge genomics to identify and eliminate the virus ’s defense mechanisms, enabling them to develop a vaccine “candidate” — meaning that it must still undergo evaluation and approval by the FDA — that in animals has been proven to be safe and highly effective against influenza.In the study, which was pu...
A synthetic version of grass pollen has been created by scientists, which cuts wheezing, itchy eyes and medication use by 25 per cent. At least a quarter of people in Britain suffer from hayfever.
Alex Rubinsteyn, Julia Kodysh, Isaac Hodes, Sebastien Mondet, Bulent Arman Aksoy, John P. Finnigan, Nina Bhardwaj, Jeffrey Hammerbacher
In the quest for improved and universal vaccines, scientists turned to a mutant virus to build an experimental flu vaccine. So far, the vaccine only has been studied in mice and ferrets.
Brazilians lined up for hours to get yellow fever vaccinations in Brazil's largest states, alarmed by the increase in the number of fatal cases of infection and a warning from the World Health Organization to tourists visiting parts of the country.Reuters Health Information
(MedPage Today) -- Text messages, postcards, and autodialer calls worked best
Although further work is needed, the scientists hope their approach will lead to an effective at-home vaccine.