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Martin Shkreli Jailed After Offering $5,000 Bounty for Hillary Clinton ’s Hair

(NEW YORK) — Former pharmaceuticals company CEO Martin Shkreli had his bail revoked and was headed to jail Wednesday while awaiting sentencing for a securities fraud conviction. A judge heard arguments about whether the provocative online antics of Shkreli, dubbed the Pharma Bro, were bad enough to put him behind bars and decided to have him taken into custody immediately. A defense attorney had argued in court papers that Shkreli’s recent offer to pay a $5,000 bounty for securing a Hillary Clinton hair with a follicle while she’s on a book tour was merely a tasteless joke comparable to some of President Donald Trump’s derisive comments, not a threat worthy of putting him behind bars. “Indeed, in the current political climate, dissent has unfortunately often taken the form of political satire, hyperbole, parody or sarcasm,” wrote the lawyer, Ben Brafman. “There is a difference, however, between comments that are intended to threaten or harass and comments — albeit offensive ones — that are intended as political satire or strained humor.” The attorney was responding to government filings last week that argued Shkreli’s behavior was threatening enough to jail him while he awaits sentencing for his securities fraud conviction. Prosecutors said the posting prompted the Secret Service to use more resources because it ran the risk that many of Shkreli’s social media followers would think he was serious. Shkrel...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Courts onetime Source Type: news

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Abstract Background: To evaluate USPIO labeling in different macrophage populations using a clinical 3.0T MR unit with optical and electron microscopy as the gold standard.Methods: Human monocytic cell line were differentiated into macrophages. Afterwards M0 macrophages were incubated with IL‐4 and IL‐13 in order to obtain M2 polarized macrophages or with IFN‐gamma and LPS for classical macrophage activation (M1). These groups were incubated with USPIO MR contrast agent (P904) for 36 hours; M0, M0+P904, M1+P904 and M2+P904 were analyzed in gel phantoms with a 3.0T MR scanner.Results: Micro‐RNA of M1 and M2 markers ...
Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
(University of Liverpool) A simple, non-invasive procedure that can indicate how long patients with cancer that has spread to the brain might survive and whether they are likely to respond to immunotherapy has been developed by researchers in Liverpool.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
There was an error in the D5-D95 in Figure  4 on page 179. The data has been corrected here. The correction to this parameter still supports the conclusion if the criteria of D5-D95 was taken as 7%.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Tags: Erratum Source Type: research
This study aims to explore whether nonalcoholic fatty liver disease (NAFLD) is a risk factor and a prognostic factor for pancreatic cancer. The study enrolled 557 patients (143 with and 414 without pancreatic cancer) who were diagnosed between January 2009 and December 2013. We reviewed the abdominal computed tomographic scans of the patients to confirm the diagnosis of NAFLD. Clinical parameters, laboratory data, and personal information were analyzed. NAFLD is an independent risk factor for pancreatic cancer according to adjusted multivariate logistic regression analysis (OR 2.63, 95% CI 1.24 –5.58,p = 0....
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
Publication date: 1 March 2018 Source:Carbohydrate Polymers, Volume 183 Author(s): Mao Yamagami, Hiroshi Kamitakahara, Arata Yoshinaga, Toshiyuki Takano This paper describes the design and synthesis of new trehalose-type diblock methylcellulose analogues with nonionic, cationic, and anionic cellobiosyl segments, namely 1-(tri-O-methyl-cellulosyl)-4-[β-d-glucopyranosyl-(1→4)-β-d-glucopyranosyloxymethyl]-1H-1,2,3-triazole (1), 1-(tri-O-methyl-cellulosyl)-4-[(6-amino-6-deoxy-β-d-glucopyranosyl)-(1→4)- 6-amino-6-deoxy-β-d-glucopyranosyloxymethyl]-1H-1,2,3-triazole (2), and 4-(tri-O-methyl-cellulo...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: November 2017 Source:Drug Discovery Today: Technologies, Volume 25 Author(s): Giulia Boscutti, Mickael Huiban, Jan Passchier The pharmaceutical industry is facing key challenges to improve return on R&D investment. Positron emission tomography (PET), by itself or in combination with complementary technologies such as magnetic resonance imaging (MRI), provides a unique opportunity to confirm a candidate’s ability to meet the so-called ‘three pillars’ of drug development. Positive confirmation provides confidence for go/no-go decision making at an early stage of the development proces...
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research
Publication date: November 2017 Source:Drug Discovery Today: Technologies, Volume 25 Author(s): Mehran Makvandi, Mark A. Sellmyer, Robert H. Mach Cancer and neurodegeneration represent two opposite ends of the biological spectrum but contain many common biological mechanisms. Two such mechanisms include the elevated levels of oxidative stress and DNA damage. In this brief review, we describe current approaches for imaging these biological pathways with the molecular imaging technique, Positron Emission Tomography (PET), and the potential of PET imaging studies to measure the efficacy of anticancer drugs and strategies for...
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research
We presented a rare diagnosis of pulsatile anterior neck swelling where a high riding brachiocephalic artery needs to be considered as a differential diagnosis. This 54-year-old lady presented with anterior neck swelling for one year which appear to be pulsatile, soft and non-tender mass. Ultrasound and Doppler scan, contrast-enhanced computed tomography (CECT) scan revealed that the neck swelling corresponds to the high riding brachiocephalic artery. Hence, ultrasound scan is essential to detect any vascular lesion prior to biopsy or fine needle aspiration cytology as to avoid catastrophic hemorrhage.
Source: Egyptian Journal of Ear, Nose, Throat and Allied Sciences - Category: ENT & OMF Source Type: research
Abstract B cells have recently entered the stage as an important accessory player in type 1 diabetes (T1D) etiopathogenesis. Experimental studies suggest regulatory functions of vitamin D on B cells. However, only a few human studies, with considerable methodological limitations, have been conducted within this field. Our objective was to investigate whether higher 25‐hydroxyvitamin D (25(OH)D) concentrations were inversely associated with β‐cell autoantigens glutamic acid decarboxylase (isoform 65) (GADA) and insulinoma‐associated antigen‐2A (IA‐2A). Further, we also wanted to examine the relationship betwe...
Source: Scandinavian Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Human Immunology Source Type: research
Conclusion MonoE at low keV of venous contrast phase scans derived from a novel SDCT are suitable for the assessment of arteries in the abdomen and subsequent stenosis assessment. However, MonoE at 40keV constantly showed significant smaller luminal diameters than the corresponding conventional reconstructions (including the reference standard). This is possibly due to an improved differentiation of the vessel lumen from the wall and raises the question, which imaging technique should be used as an appropriate reference standard for vascular SDCT imaging studies.
Source: European Journal of Radiology - Category: Radiology Source Type: research
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