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Larry King says he had Stage 1 lung cancer

Larry King revealed to "Extra" host Mario Lopez that he was diagnosed with Stage 1 lung cancer
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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This study investigated the role of miR‐339‐5p involvement in lung carcinoma cell lines and chemoresistance to Taxol. We observed that miR‐339‐5p was significantly downregulated in Taxol‐A549 cells compared with A549 cells. In vitro studies further indicated that miR‐339‐5p could promote colony formation and attenuate apoptosis of lung carcinoma cell lines through targeting α1,2‐fucosyltransferase 1 and regulation of the downstream protein Lewis y. Furthermore, miR‐339‐5p was found to enhance the proliferation inhibition ability of Taxol in lung carcinoma cell lines as well as in the Taxol‐A549 ...
Source: IUBMB Life - Category: Research Authors: Tags: Research Communication Source Type: research
Recent strides in cardiovascular medicine have produced an evident prolongation of life. Thus, cancer mortality, the second leading cause of death, is closely rivalling that from circulatory diseases [1]. Death rates from colorectal cancer (CRC) are second only to lung cancer in men and breast cancer in women [1]. North Americans and Europeans are more prone to CRC than the rest of the world, with an estimated lifetime risk of 5% [2]. Adenomas, the precursors of most CRC, are estimated to occur in 20 –50% of Western individuals older than 50years [2].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
This study was to explore the relevance between serum tumor markers and treatment of EGFR-TKIs. Methods We retrospectively collected the clinical information of advanced lung adenocarcinoma patients harboring EGFR mutation, who received EGFR-TK Is as first-line therapy from June 2009 to June 2014 in Peking University Cancer Hospital, analyzed the relationship between serum tumor markers and efficacy of EGFR-TKIs. Results The objective response rate (ORR) was 52.8% and the disease control rate (DCR) was 89.3%. The results showed that, patie nts with high CEA level before treatment responded better to TKIs (ORR 61.3% vs 35.9...
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
It’s down to just four companies in the 2017 MedTech Innovator $500K Competition, whittled down from a field of almost 600 companies. The finalists, which emerged from the 20-company MedTech Innovator Accelerator, will vie for the top prize next week. Representatives from each company will pitch to an audience and judging panel during a session at The MedTech Conference in San Jose, CA on September 26. The panel of judges, which includes leaders from Johnson &Johnson, Baxter Ventures, Becton Dickinson, and Kaiser Permanente Ventures, will ask questions before the session audience casts their votes. The medical te...
Source: MDDI - Category: Medical Devices Authors: Tags: Medical Device Business Source Type: news
AbstractPhysical activity has been associated with lower lung cancer risk in numerous studies with estimates ranging from 20 to 50% lower risk in the most versus the least active study participants. Underweight and obesity have also been associated with lower lung cancer risk, with a nonlinear, inverted U-shaped relationship. However, associations of physical activity and obesity with lung cancer are likely significantly confounded by smoking since individuals who smoke are generally less active and leaner than non-smokers, but few studies have examined these associations stratified by smoking status. Using data from 162,6...
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Conclusion Adding metformin to chemotherapy for advanced NSCLC was safe but did not significantly improve clinical outcomes compared to historical phase III controls. These results are limited by the small sample size; larger trials are needed.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 21 September 2017 Source:Pathology - Research and Practice Author(s): Huiyan Deng, Junying Liu, Xiaojin Duan, Yueping Liu To detect the relationship of the epidermal growth factor receptor (EGFR) mutation status and the clinicopathologic features. Six hundred thirty-three patients with pathologically confirmed lung adenocarcinoma who underwent lung cancer resection surgery at the Fourth Hospital of Hebei Medical University between April 2012 and April 2015 were selected for the study. The 32 types of mutations in exons 18–21 of the EGFR gene were detected. The total EGFR mutation r...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
AbstractBackgroundPemetrexed is the preferred chemotherapy agent in the management of non-squamous non-small cell lung cancer (non-sq-NSCLC), but lacks biomarkers predicting its efficacy. Dexamethasone, one of the premedications of pemetrexed, may downregulate p53 through the glucocorticoid receptor (GR). The purpose of our study was to explore the effect of GR in peripheral blood mononuclear cells (PBMC) and its role in predicting pemetrexed efficacy.MethodsIn all, 122 patients with stage IV non-sq-NSCLC who received first-line pemetrexed-containing chemotherapy were retrospectively reviewed. The expression of GR in PBMC ...
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
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Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Bristol-Myers Squibb's immunotherapy drug Opdivo has been recommended for some patients with lung cancer by Britain's healthcare cost watchdog NICE after the drugmaker agreed a discounted price.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
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