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Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.

Wiederhold NP, Patterson TF, Srinivasan A, Chaturvedi AK, Fothergill AW, Wormley FL, Ramasubramanian AK, Lopez-Ribot JL.Virulence. 2017 Feb 17;8(2):138-142.Abstract:  Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Mon, 09/18/2017 - 15:12News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Abstract BackgroundProspective studies to determine associated risk factors and related outcomes for pulmonary fungal infection (PFI) after pediatric lung transplant (PLT) are lacking. MethodsNIH‐sponsored Clinical Trials in Organ Transplantation in Children enrolled PLT candidates, collecting data prospectively for 2 years post‐transplant. Demographics, signs/symptoms, radiology, pathology and microbiology were collected. Analyses evaluated for PFI‐related risks and outcomes. ResultsIn 59 PLT, pre‐transplant fungal colonization occurred in 6 donors and 15 recipients. Cystic fibrosis (CF) was associated with pre‐...
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
Diagnosis and Treatment of Mucormycosis in Patients withHematological Malignancies[Translated Article]. Med Mycol J. 2017;58(3):E97-E105 Authors: Asano-Mori Y Abstract The risk of invasive fungal infections (IFIs) is extremely high in patients with hematological malignancies due to the prolonged and profound neutropenia and immunosuppression after chemotherapy and hematopoietic stem cell transplantation. There has been increasing interest in mucormycosis despite its relatively uncommon occurrence, because occasional breakthrough infections have been observed under anti-Aspergillus prophylaxis. The ...
Source: Medical Mycology Journal - Category: Biology Tags: Med Mycol J Source Type: research
We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. While receiving liposomal amphotericin B, a sinusal aspergillosis due to Aspergillus fumigatus occured. Evolution was slowly favorable under antifungal tritherapy by liposomal amphotericin B, posaconazole and caspofungin.
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
FIT publish a detailed summary of the worldwide total burden of fungal disease on their website. It has just beenupdated here. Updates
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
C Agrawal, V Sood, A Kumar, V RaghavanIndian Journal of Nephrology 2017 27(5):392-394 Invasive fungal infections (IFIs) are a significant cause of morbidity in solid organ transplant (SOT) recipients. Common causes among them are Aspergillus, Candida, and Cryptococcus. Antifungal prophylaxis has led to decrease in overall incidence of IFI; however, there is very little decline in the incidence of Cryptococcal infections of SOT recipients because effective prophylaxis is not available against this infectious agent. Spectrum of manifestation of Cryptococcal infection varies in immunocompetent and immunocompromised host with...
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Rationale: The simultaneous occurrence of pyoderma gangrenosum (PG) and chronic granulomatous disease (CGD) is uncommon and few cases have been reported worldwide. Patient concerns: PG is a rare, chronic, ulcerative, neutrophilic skin disease of unknown etiology that requires immunosuppressive treatment. CGD belongs to Primary Immune Deficiencies in which the main defect lies in an inability of the phagocytic cells to generate superoxide making patients susceptible to serious, potentially life-threatening bacterial and fungal infections. Diagnoses: In this manuscript, we present a case of ulcerative pyoderma gangrenosum ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Abstract Host‐fungus interactions have gained a lot of interest in the past few decades, mainly due to an increasing number of fungal infections that are often associated with a high mortality rate in the absence of effective therapies. These interactions can be studied at the genetic level or at the functional level via imaging. Here, we introduce a new image processing method that quantifies the interaction between host cells and fungal invaders, for example, alveolar macrophages and the conidia of Aspergillus fumigatus. The new technique relies on the information content of transmitted light bright field microscopy im...
Source: Cytometry Part A - Category: Molecular Biology Authors: Tags: Original Article Source Type: research
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Invasive fungal infections are rare in children with acute lymphoblastic leukemia. It compromises the antileukemia therapy should it happen. Central nervous system fungal infections carry high mortality. We here report the case of a 6.5-year-old girl who developed multiple central nervous system fungal abscesses possibly due to Aspergillus infection during induction therapy for acute lymphoblastic leukemia who has been successfully managed without compromising antileukemia therapy. She has been receiving antifungal therapy and maintenance chemotherapy for 20 months from diagnosis. We reviewed literature about the optimal d...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
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