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Temple scientists land $11.6M grant to explore heart repair & regeneration

The National Institutes of Health has awarded scientists at the Lewis Katz School of Medicine at Temple University a $11.6 million grant to explore the development of stem cell-based treatments for heart repair and regeneration. The project, funded by the National Heart, Lung, and Blood Institute of the NIH, is aimed at better understanding the regenerative capabilities of stem cell-derived microvesicles known as exosomes. Gene-editing company taking on HIV raises $10M Raj Kishore, a professor…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Researchers here report on a cheaper implementation of encapsulation for transplanted stem cells, preventing the recipient's immune system from attacking cells originating from a different individual or even different species. Since the stem cells produce improvement in regeneration in heart tissue via signaling, there is no need to expose the cells themselves to the local environment - the cells are only needed at all because the signaling environment is not yet fully mapped and understood. Encapsulating transplanted cells in a nanogel extends their lifetime and thus the therapeutic effect. As a promising approa...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ACS NanoDOI: 10.1021/acsnano.7b01008
Source: ACS Nano - Category: Nanotechnology Authors: Source Type: research
(American Chemical Society) Heart disease and heart-related illnesses are a leading cause of death around the world, but treatment options are limited. Now, one group reports in ACS Nano that encapsulating stem cells in a nanogel could help repair damage to the heart.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Publication date: September 2017 Source:Chinese Chemical Letters, Volume 28, Issue 9 Author(s): Quan Wang, Jianxiang Xu, Haiming Jin, Wenhao Zheng, Xiaolei Zhang, Yixing Huang, Zhiyong Qian Periosteum is a thin membrane that encases the surfaces of most bones. It is composed of an outer fibrous layer contains longitudinally oriented cells and collagen fibers and an inner cambial layer that consists of multipotent mesenchymal stem cells (MSCs) and osteogenic progenitor cells. Periosteum has a function of regulating cell and collagen arrangement, which is important to the integrity, modelling and remodelling of bone, partic...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Sujeong Jang, Hyong-Ho Cho, Jong-Seong Park, Han-Seong Jeong Bone marrow-derived mesenchymal stem cells (BM-MSCs), which are characterized by multipotency and self-renewal, are responsible for tissue regeneration and repair. We have previously reported in adipose tissue-derived MSCs that only Wnt5a is enhanced at neurogenic differentiation, and the mechanism of differentiation is dependent on the Wnt5a/JNK pathway; however, the role of Wnt/MAPK pathway is yet to be investigated in neurogenic differentiation in BM-MSCs. We compared the tra...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
In this study, researchers put some numbers to the correlation, and improve on previous attempts to rule out wealth and other effects as significant contributing causes. A study finds that a Chinese policy is unintentionally causing people in northern China to live 3.1 years less than people in the south, due to air pollution concentrations that are 46 percent higher. These findings imply that every additional 10 micrograms per cubic meter of particulate matter pollution reduces life expectancy by 0.6 years. The elevated mortality is entirely due to an increase in cardiorespiratory deaths, indicating that air poll...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Biotechnology and Bioengineering - Category: Biomedical Science Authors: Tags: Article Source Type: research
Contributors : Ragnhild Eskeland ; Madeleine L Fosslie ; Arvind Y SundaramSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChanges to the composition of nucleosomes, such as histone variant replacements, are important mechanisms for chromatin-based gene regulation. Histone variant H2A.Z.1 is essential in mouse and has been linked to transcriptional activation and repression, genome integrity, chromosome segregation, cell-cycle control and proliferation, DNA replication and repair. H2A.Z.2 differs from H2A.Z.1 in only three amino acids, however it remains elusive whether the H2A.Z isofo...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Ragnhild Eskeland ; Madeleine L Fosslie ; Antonio Mora ; Akshay ShahSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusChanges to the composition of nucleosomes, such as histone variant replacements, are important mechanisms for chromatin-based gene regulation. Histone variant H2A.Z.1 is essential in mouse and has been linked to transcriptional activation and repression, genome integrity, chromosome segregation, cell-cycle control and proliferation, DNA replication and repair. H2A.Z.2 differs from H2A.Z.1 in only three amino acids, however it remains elusive ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Conclusion There is a growing clinical demand for a tissue engineered alternative to traditional management strategies. Currently, there is limited consensus regarding material selection for use in tissue engineered ligaments. Further research is required to optimize tissue engineered ligament production before clinical application. Controlled clinical trials comparing the use of tissue engineered ligaments and traditional management in patients with knee ligament injury could determine whether they can provide a cost-effective alternative. PMID: 28914209 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
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