Log in to search using one of your social media accounts:

 

Temple scientists land $11.6M grant to explore heart repair & regeneration

The National Institutes of Health has awarded scientists at the Lewis Katz School of Medicine at Temple University a $11.6 million grant to explore the development of stem cell-based treatments for heart repair and regeneration. The project, funded by the National Heart, Lung, and Blood Institute of the NIH, is aimed at better understanding the regenerative capabilities of stem cell-derived microvesicles known as exosomes. Gene-editing company taking on HIV raises $10M Raj Kishore, a professor…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

Related Links:

Conclusions: Tadalafil prolonged MSCs survival via up‐regulation of miR‐21 dependent suppression of Fas, and increased MSCs mobilization and their homing into infarcted myocardium resulting in improved cardiac repair and function. Tadalafil prolonged MSCs survival in vitro and in vivo, and increased MSCs mobilization and their homing into infarcted myocardium resulting in improved cardiac repair and function.
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
Publication date: 14 November 2017 Source:Stem Cell Reports, Volume 9, Issue 5 Author(s): Andre Chow, Daniel J. Stuckey, Emaddin Kidher, Mark Rocco, Richard J. Jabbour, Catherine A. Mansfield, Ara Darzi, Sian E. Harding, Molly M. Stevens, Thanos Athanasiou Tissue engineering offers an exciting possibility for cardiac repair post myocardial infarction. We assessed the effects of combined polyethylene glycol hydrogel (PEG), human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM), and erythropoietin (EPO) therapy in a rat model of myocardial infarction. PEG with/out iPSC-CMs and EPO; iPSC-CMs in saline; or saline...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Adult neurogenesis, a complex process by which stem cells in the hippocampal brain region differentiate and proliferate into new neurons and other resident brain cells, is known to be affected by many intrinsic and extrinsic factors, including diet. Neurogenesis plays a critical role in neural plasticity, brain homeostasis, and maintenance in the central nervous system and is a crucial factor in preserving the cognitive function and repair of damaged brain cells affected by aging and brain disorders. Intrinsic factors such as aging, neuroinflammation, oxidative stress, and brain injury, as well as lifestyle factors such as...
Source: Advances in Nutrition - Category: Nutrition Authors: Tags: Reviews Source Type: research
Cell source plays a key role in cell-based cartilage repair and regeneration. Recent efforts in cell coculture have attempted to combine the advantages and negate the drawbacks of the constituent cell types. T...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
.
Source: Expert Opinion on Biological Therapy - Category: Drugs & Pharmacology Authors: Source Type: research
We present here a pilot clinical trial using autologous bone-derived mesenchymal stem cells (H-MSV) grown in a serum cross-linked scaffold (BioMax) for treatment of maxillary cysts in 9 patients. Cells obtained from alveolar bone were seeded in the BioMax scaffold prepared from autologous serum, expanded under GMP conditions, and subjected to osteogenic differentiation for 3-4 weeks before application.
Source: Journal of Cranio-Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
In this study, a novel three-dimensional scaffold (RADA4GGSIKVAV; R-GSIK) was designed by adding glycine and serine between RADA4 and IKVAV to promote the strength of the peptide. The cell adhesion, viability, proliferation, migration, and differentiation of rat embryonic neural stem cells (NSCs) in R-GSIK were investigated and compared to laminin-coated, two-dimensional, and Puramatrix cultures. The scanning electron microscopy studies of the R-GSIK showed an open porous structure and a suitable surface area available for cell interaction. R-GSIK promoted the cell adhesion, viability, proliferation, and migration compared...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
BACKGROUND: Regenerating muscle at a time remote from injury requires re-expression of cytokines to attract stem cells to start and sustain the process of repair. OBJECTIVE: We aimed to evaluate the sustainability of muscle regeneration after treatment with a nonviral plasmid expressing stromal cell-derived factor 1. DESIGN: This was a randomized study. SETTINGS: The study was conducted with animals in a single research facility. INTERVENTIONS: Fifty-six female age-/weight-matched Sprague–Dawley rats underwent excision of the ventral half of the anal sphincter complex. Three weeks later, rats were rando...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Pelvic Floor Source Type: research
Sepsis and consequent septic shock occur more frequently in the old and cause greater harm and mortality in older individuals. The condition occurs when an infection spurs the immune system into a state of runaway inflammation and then shutdown, sufficient to disrupt or permanently damage metabolism and organ function. The open access paper here dives into the details of age-related immune system dysfunction, with an eye to explaining why exactly these failures cause sepsis to be both worse and more prevalent in the elderly. As for so many of the specific frailties of old age, the best solution is to repair the immune syst...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Abstract The adhesion and migration of cells entrapped in engineered materials is regulated by available adhesive ligands. Although mesenchymal stem cell (MSC) spheroids injected into damaged tissues promote repair, their transplantation in biomaterials which regulate cell migration from the aggregate may further enhance their therapeutic potential. Alginate hydrogels were modified with Arginine-Glycine-Aspartic acid (RGD) at increasing concentrations, and osteogenically induced human MSC spheroids were entrapped to assess cell migration, survival, and differentiation. Cell migration was greater from MSC spheroids...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research
More News: Cardiology | Gastroschisis Repair | Genetics | Grants | Health Management | Heart | National Institutes of Health (NIH) | Pharmaceuticals | Stem Cell Therapy | Stem Cells