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Temple scientists land $11.6M grant to explore heart repair & regeneration

The National Institutes of Health has awarded scientists at the Lewis Katz School of Medicine at Temple University a $11.6 million grant to explore the development of stem cell-based treatments for heart repair and regeneration. The project, funded by the National Heart, Lung, and Blood Institute of the NIH, is aimed at better understanding the regenerative capabilities of stem cell-derived microvesicles known as exosomes. Gene-editing company taking on HIV raises $10M Raj Kishore, a professor…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Complete eradication of aggressive oral cancer remains a challenge due to the presence of CSCs. They resist to conventional chemotherapeutic agents due to their self-renewal, drug efflux, and efficient DNA repair capacity. Here, we formulated a hybrid-nanoparticle (QAuNP) using quinacrine and gold and characterized; investigated its anti-angiogenic and anti-metastatic effect on OSCC-CSCs. QAuNP significantly inhibited cellular proliferation, caused apoptosis in vitro, disrupted angiogenesis in vivo and tumor regression in xenograft mice model.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - Category: Nanotechnology Authors: Source Type: research
Conditions:   Diabetes Complications;   Diabetic Retinopathy Intervention:   Biological: Generation of inducible pluripotent stem cells Sponsor:   University of Alabama at Birmingham Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
PMID: 29348245 [PubMed - in process]
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
In conclusion, taken together our results suggest the high potential of autologous CM as a promising tool to modulate behaviour of MSCs thus improving their use in therapeutically approaches. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Stem cell-based therapies are an attractive option to promote regeneration and repair defective tissues and organs. Thanks to their multipotency, high proliferation rate and the lack of major ethical limitatio...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Methodology article Source Type: research
Stem cells are critical for normal tissue homeostasis and injury-induced regeneration, but how wounding affects tissue regeneration at the cellular and molecular levels is not yet fully understood. A new study by Yui et al (2018) demonstrates that the extracellular matrix (ECM) remodeling modulates intestinal stem cells in tissue repair and regeneration via activation of the Hippo pathway effectors YAP/TAZ.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Development & Differentiation, Signal Transduction, Stem Cells News [amp ] Views Source Type: research
Mitochondria are the power plants of the cell, a herd of self-replicating structures evolved from ancient symbiotic bacteria, now fully integrated into the cell. Their primary task is the production of chemical energy stores, an energetic process that produces damaging reactive molecules as a side-effect. Much of the original bacterial DNA of the distant ancestors of today's mitochondia has migrated to the cell nucleus, leaving only a tiny remnant genome in the mitochondria themselves. When looking across species with widely divergent life spans, researchers have found good correlations between species life span and some c...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - Category: Stem Cells Authors: Source Type: research
Heart muscle patches are thin engineered sections of tissue, lacking blood vessels because construction of microvasculature is still an unsolved challenge, and small because without blood vessels there is a size limit on engineered tissue. The study here suggests that we should be thinking of a present-day heart muscle patch, and most of its structure and cells, as a disposable vehicle to deliver only a fraction of its cells, keeping them alive long enough to engraft alongside native cells. The rest of the cells in the patch last only long enough to temporarily change the balance of signaling in an aged or injured heart. T...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
This study is the longest, prospective randomized controlled trial that has documented the physiological effects of supervised, structured exercise training in a group of sedentary but healthy middle-aged adults. The key finding is that 2 years of exercise training performed for at least 30 minutes, 4 to 5 days per week, and including at least 1 high-intensity interval session per week results in a significant reduction in LV chamber and myocardial stiffness. The use of high-resolution, invasively measured LV pressure-volume curves and comparison with an attention control group enhances the confidence in this conclusion. T...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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