Why age matters when it comes to cervical cancer screening
What to know about testing options that can detect early warning signs of cancer and help prevent it
In conclusion, we demonstrated that this 5-peptide vaccine was tolerable, and that FOXM1 and MELK could be promising targets for immunotherapy in patients with cervical cancer.
Conclusion Pacific Islanders referred to TAMC present with a disproportionally higher rate of regional and advanced disease. Significantly, only 28% of invasive cervical cancers in the Pacific Island population sampled could have been potentially be prevented using the available quadrivalent vaccine targeting HPV 16/18; however, 88% could be covered by the recently licensed nonavalent vaccine.
This study evaluates a novel technique of laparoscopic ovarian transposition performed by Gynecologic Oncologists prior to pelvic radiation for gynecologic cancer. A retrospective review was completed of all patients that underwent laparoscopic ovarian transposition from February 2007 to June 2017 at one tertiary care cancer. The technique involves salpingectomy, followed by retroperitoneal dissection to move the ovaries lateral to the hepatic and splenic flexures of the colon. Normal ovarian function was defined by the absence of vasomotor symptoms, FSH and menstrual history (if menstruating). The radiation dose to the ov...
Immunodeficiency, whether congenital or acquired, iatrogenic (e.g. allograft recipients) or infectious (e.g. human immunodeficiency virus (HIV)), is associated with an increased risk of malignancy. In the case of HIV infection, most cancers are associated with oncogenic virus infection. Although the overall risk of any cancer is increased 2 –3-fold in people living with HIV, there are three acquired immune deficiency syndrome (AIDS)-defining cancers whose relative risk is dramatically higher. These three AIDS-defining illnesses are Kaposi's sarcoma, high-grade B cell non-Hodgkin's lymphoma (including primary cerebral...
CONCLUSIONS This study is the first to provide evidence that propofol-mediated autophagy regulation is an underlying part of the mechanism by which propofol regulates HeLa cells progression. PMID: 29667627 [PubMed - in process]
(European Society for Radiotherapy and Oncology (ESTRO)) New research presented at the ESTRO 37 conference from two large international trials, shows that intracavitary and interstitial brachytherapy is safe and does not increase the risk of ureteral stricture in cervical cancer patients. Until now, there have been concerns that brachytherapy might increase the risk of this serious, sometimes life-threatening complication, although the treatment itself is associated with better survival.
The World Health Organization (WHO) estimates more 270000 deaths annually by cervical cancer. Present vaccines are prophylactic in nature which cannot treat huge bulk of cervical cancer patients worldwide. Available therapies like radiotherapy, chemotherapy or surgery are not effective in high grade lesion and hence, there is an unmet medical need for an effective form of therapy. T cells play a significant role in cervical cancer pathogenesis as Human Papilloma Virus (HPV) uses multiple mechanisms that dodge host T cell immune-surveillance aiding in persistence of infection and establishment of cancer.
Authors: Verburg F, Maeder U, Giovanella L, Luster M, Reiners C Abstract BACKGROUND: Neck ultrasound (NUS) is currently seen as a main component of follow-up of differentiated thyroid cancer (DTC) and is usually performed regardless of non-stimulated thyroglobulin (Tg) levels. The aim of this study is to determine whether there is a clinical benefit from such a routine NUS in DTC patients. METHODS: We performed a retrospective database study of 3176 cervical ultrasound exams performed in 773 patients between June 15, 1996 and July 1, 2012. The assessement of the accuracy of ultrasound results was assessed based...
After going public with her cervical cancer diagnosis in 2017, Erin Andrews is partnering with women's health diagnostics company Hologic to get women talking about the " C-word. "
Conclusions: Despite the increased incidence of gynecological malignancies in obese, we found no significant impact of BC including VAT on patient survival. Further studies with larger cohorts are needed to quantify BC and its metabolomic impact regarding treatment and prognosis. PMID: 29662648 [PubMed]