Targeting Inhibition of SmpB by Peptide Aptamer Attenuates the Virulence to Protect Zebrafish against Aeromonas veronii Infection

Peng Liu, Dongyi Huang, Xinwen Hu, Yanqiong Tang, Xiang Ma, Rihui Yan, Qian Han, Jianchun Guo, Yueling Zhang, Qun Sun, Zhu Liu
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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The morbidity and mortality resulting from acute gastroenteritis and associated chronic sequelae represent a substantial burden on health care systems worldwide. Few studies have investigated changes in the gut microbiome following an episode of acute gastroenteritis. By using nondirected 16S rRNA gene amplicon sequencing, the fecal microbiota of 475 patients with acute gastroenteritis was examined. Patient age was correlated with the overall microbial composition, with a decrease in the abundance of Faecalibacterium being observed in older patients. We observed the emergence of a potential Escherichia-Shigella-dominated e...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host-Associated Microbial Communities Source Type: research
In this study, curcumin liposomes were prepared by film dispersion method to increase its bioavailability against QS systems of food-borne epathogenic bacteria, i.e. Aeromonas hydrophila and Serratia grimesii. And their physicochemical properties were measured including particle size, zeta-potential entrapment rate as well as drug-loading rate. Meanwhile, the effects of curcumin liposomes on QS phenomenon of food-borne pathogens including biofilm formation, extracellular protease, swimming motility et al. were determined. Results showed that the average diameter of curcumin liposomes was (207 ± 8.2) nm and the e...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: September 2018 Source:Fish & Shellfish Immunology, Volume 80 Author(s): Dandan Huang, Zhiyi Bai, Jiexuan Shen, Liting Zhao, Jiale Li Tumor necrosis factor receptor-associated factor 6 (TRAF6) acts as a central intracellular signal adapter molecule that mediates the tumor necrosis factor receptor superfamily and the interleukin-1 receptor/Toll-like receptor family in vertebrates and invertebrates. In the present study, HcTRAF6, a molluscan homologue of TRAF6 from Hyriopsis cumingii, has been cloned and identified. The entire open reading frame of HcTRAF6 was found to comprise a 1965-bp region that enc...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: September 2018 Source:Fish & Shellfish Immunology, Volume 80 Author(s): Prapansak Srisapoome, Nawanith Klongklaew, Nontawith Areechon, Ratree Wongpanya Anti-lipopolysaccharide factor (ALF) is an immune-related protein that is crucially involved in immune defense mechanisms against invading pathogens in crustaceans. In the current study, three different ALFs of giant river prawn (Mr-ALF3, Mr-ALF8 and Mr-ALF9) were discovered. Based on sequence analysis, Mr-ALF3 and Mr-ALF9 were identified as new members of ALFs in crustaceans (groups F and G, respectively). Structurally, each newly identified Mr-ALF c...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In conclusion, dietary yeast nucleotide administration at 0.25% improved blood proteins, leukocytes, antioxidant activity, non-specific immunity, cytokine gene expression, and disease resistance of Nile Tilapia.
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In this study, two bacteriophage isolates, AhSzq-1 and AhSzw-1 that specifically infectAeromonas hydrophila strain KT998822, were isolated from seawater and characterized. One-step growth curves showed that the latent period of AhSzq-1 and AhSzw-1 are 50 min and 60 min, respectively. The sequence similarities between AhSzq-1 and AhSzw-1 were 88% at the DNA and 83% at the protein level, suggesting that these two phages are representatives of two different species. The virion morphology, DNA genome size and terminal repeats of these two phages are similar to those of viruses classified asT5virus phages. Both phylogenetic ana...
Source: Archives of Virology - Category: Virology Source Type: research
In this study, paTLR5 and paTLR9 were identified in silver pomfret (Pampus argenteus), a marine teleost of great economic value. Open reading frames (ORFs) of paTLR5 and paTLR9 are 2646 and 3225 bp, encoding polypeptides of 881 and 1074 amino acids, respectively. Sequence analysis revealed several conserved characteristic features, including signal peptides, leucine-rich repeat (LRR) motifs, and a Toll/interleukin-I receptor (TIR) domain. Sequence, phylogenetic and synteny analysis revealed high sequence identity with counterparts in other teleosts, confirming their correct nomenclature and conservation during evolution....
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
MicrobiologyOpen, EarlyView.
Source: MicrobiologyOpen - Category: Microbiology Authors: Source Type: research
Abstract The success of the pathogenic bacteria is partly attributable to their ability to thwart host innate immune responses, which includes resisting the antimicrobial functions of macrophages. And reactive oxygen species (ROS) is one of the most effective antimicrobial components of macrophages to kill invading bacteria. Our previous studies found that Aeromonas hydrophila can survive in fish macrophages, which suggested that this bacterium might take fish macrophages as their shelters to resist drug killings and other immune damage. But how A. hydrophila survive in host macrophages remains unknown. Since KatG...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
A red bellied piranha (Pygocentrus nattereri), kept as a pet by a private owner, was presented for multifocal ulcerative lesions. Lesion biopsies were collected under general anesthesia and submitted for histopathology and microbiology examination. Histological examination revealed a bacterial necrotizing ulcerative dermatitis. From cultural analysis of the biopsy, Aeromonas hydrophila and Edwardsiella ictaluri were isolated. Multi-drug resistance was observed in both isolates except for neomycin and ceftazidime.
Source: Journal of Exotic Pet Medicine - Category: Veterinary Research Authors: Tags: Case Report Source Type: research
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