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Targeting Inhibition of SmpB by Peptide Aptamer Attenuates the Virulence to Protect Zebrafish against Aeromonas veronii Infection

Peng Liu, Dongyi Huang, Xinwen Hu, Yanqiong Tang, Xiang Ma, Rihui Yan, Qian Han, Jianchun Guo, Yueling Zhang, Qun Sun, Zhu Liu
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Authors: Kai C, Denglan Z, Jingxuan D, Yijun Z Abstract [This retracts the article on p. 185 in vol. 9.]. PMID: 28932327 [PubMed]
Source: Open Biomedical Engineering Journal - Category: Biomedical Engineering Tags: Open Biomed Eng J Source Type: research
Conclusion This study shows that the strains tested are of potential public health concern and emphasize that wild animals are potential reservoirs of multidrug resistant strains. In fact, Aeromonas species are consistently considered opportunistic pathogens. Moreover, bacterial ability to form biofilms increases antimicrobial resistance and the propensity to cause persistent infections.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
AbstractAeromonas hydrophila is responsible for causing fatal infections in freshwater fishes. Besides chemical/antibiotic treatment and whole-cell vaccine, no subunit vaccine is currently available forA. hydrophila. Outer membrane proteins of gram-negative bacteria have been reported as effective vaccine candidates. Peptide antigens elicit focused immune responses against immunodominant stretches of the antigen. We have attempted to characterize the immunogenicity of linear B-cell epitopes of outer membrane protein (OmpC) ofA. hydrophila identified using in silico tools, in conjugation with heat-labile enterotoxin B (LTB)...
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research
Authors: Ulukanli Z, Ulukanli S, Ozbay H, Ilcim A, Tuzcu M Abstract Crude extracts obtained from the roots and aerial parts of Rumex crispus.L. and Acinos rotundifolius.Pers. and the whole plants of Ajuga chamaepitys. L. and of Lycopus europaeus. L. were evaluated for in vitro. antimicrobial activity against five Gram-positive bacteria including Staphylococcus aureus., Micrococcus luteus, Mycobacterium smegmatis, Bacillus subtilis, Bacillus subtilis. var. niger., and three Gram-negative bacteria including Aeromonas hydrophila, Klebsiella pneumoniae, Pseudomonas aeruginosa., and the yeast Candida albicans.. The inhi...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Conclusions The current study reveals the mismatch phenomenon between quinolone resistance phenotype and genotype of turtle-borne aeromonads and suggests that susceptible isolates might be a potential risk source for storage and transmission of resistance genes.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: November 2017 Source:Fish & Shellfish Immunology, Volume 70 Author(s): Jiong Wu, Miaomiao Bao, Delong Ge, Liping Huo, Zhenming Lv, Changfeng Chi, Zhi Liao, Huihui Liu Superoxide dismutases (SODs), a by-product of antioxidative defence system, protects organisms for eliminating excess reactive oxygen species (ROS) and maintaining the redox balance of immune system. The complete open reading frames (ORFs) of Cu/Zn-SOD and Mn-SOD were identified from Mytilus coruscus (designated as McSOD and MnSOD) by homologous cloning. The sequence lengths were 474bp and 687bp, encoding 157 and 228 amino acids respect...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: November 2017 Source:Fish & Shellfish Immunology, Volume 70 Author(s): Sajjad Syed Raffic Ali, Kondusamy Ambasankar, Mohamed Saiyad Musthafa, Ramasamy Harikrishnan A 45 days feeding trial was conducted to study the effect of Jerusalem artichoke (JA) on growth performance, body composition, biochemical, immuno-hematological parameters and disease resistance in Asian seabass (Lates calcarifer) fingerlings against Aeromonas hydrophila. JA was supplemented at three different levels viz., control 0, 5, 10, and 20 g kg−1 in the commercial diet (403 g kg−1protein and 89 g&nbs...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
This study sought to shed light on the bacterial pathogens causing secondary infections in tungiasis lesions and their susceptibility profiles to commonly prescribed antibiotics. Participants were recruited with the help of Community Health Workers. Swabs were taken from lesions which showed signs of secondary infection. Identification of suspected bacteria colonies was done by colony morphology, Gram staining, and biochemical tests. The Kirby Bauer disc diffusion test was used to determine the drug susceptibility profiles. Out of 37 participants, from whom swabs were collected, specimen were positive in 29 and 8 had no gr...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
In this study, we evaluated the biological parameters and immune enzymes in the liver of grass carp following A. hydrophila infection and quantified the alterations in liver histology using a semi-quantitative system. For the biological parameters, we found that the liver somatic index (LSI) was more sensitive than Fulton's condition factor (CF) and was significantly decreased at three days post-injection (DPI). At the immune enzyme level, the level of peroxidase (POD) in the liver significantly increased at 1 and 3 DPI. The activity of alkaline phosphatase (ALP) significantly increased at 3 DPI. Similarly, acid phosp...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Conclusions Presence of such resistance genes in plasmids further adds complexity for control of spread of carbapenem resistance. This study reveals the emergence of carbapenem resistance among Aeromonas spp. and the importance of mobile genetic elements such as plasmids in interchanging resistance determinants between species.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
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