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ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis

In this study, we found thatERAP1 andPDE8A were downregulated in vaccinated cattle that were protected from experimentalM. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.J Mol Microbiol Biotechnol 2017;27:237-245
Source: Journal of Molecular Microbiology and Biotechnology - Category: Microbiology Source Type: research

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In this study, we found thatERAP1 andPDE8A were downregulated in vaccinated cattle that were protected from experimentalM. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.J Mol Microbiol Biotechnol 2017;27:237-245
Source: Journal of Molecular Microbiology and Biotechnology - Category: Microbiology Source Type: research
ABSTRACT Pneumonia in the tropics poses a heavy disease burden. The complex interplay of climate change, human migration influences and socio‐economic factors lead to changing patterns of respiratory infections in tropical climate but also increasingly in temperate countries. Tropical and poorer countries, especially South East Asia, also bear the brunt of the global tuberculosis (TB) pandemic, accounting for almost one‐third of the burden. But, as human migration patterns evolve, we expect to see more TB cases in higher income as well as temperate countries, and rise in infections like scrub typhus from ecotourism act...
Source: Respirology - Category: Respiratory Medicine Authors: Tags: Invited Review Series: Respiratory Infections in the Asia ‐Pacific Region Source Type: research
In conclusion, collaborative molecular epidemiological studies are needed in conjunction with researchers working in medicine and veterinary fields to determine precisely the importance of zoonotic TB in human TB in our country, to determine the route of transmission to humans and risk factors for zoonotic TB infections, to identify the dominant types between humans and animals and to understand the phylogeographic relationships of the strains in our country. PMID: 28566080 [PubMed - in process]
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
In this report, we present an 8-year-old female patient admitted with cough, fever, and sputum persisting since 2 weeks; her chest radiography and computed tomography (CT) findings initially indicated Tbc, but the follow-up surgery led to a diagnosis of ruptured lung CE. We want to emphasize that in children belonging to places where livestock is common, if respiratory symptoms are observed, CE and tuberculosis must be considered in the differential diagnosis, and the final diagnosis should be supported by other microbiological-serological tests. PMID: 28695838 [PubMed - in process]
Source: Turkish Society for Parasitology - Category: Parasitology Authors: Tags: Turkiye Parazitol Derg Source Type: research
Conclusion : No cases of the disease caused by this zoonotic agent were documented in the departments of Antioquia, Boyacá and Cundinamarca. PMID: 28453114 [PubMed - in process]
Source: Revista de Salud Publica - Category: Global & Universal Tags: Rev Salud Publica (Bogota) Source Type: research
Mycobacterium microti is a member of the Mycobacterium tuberculosis complex (MTBC), which also includes major human and animal pathogens such as M tuberculosis and Mycobacterium bovis. Mmicroti was originally described as the cause of tuberculosis in wild rodents, but it can also infect several other animal species, including people, highlighting its zoonotic potential (Cavanagh and others 2002, Panteix and others 2010). In 2015, we reported a case of Mmicroti infection in a dairy goat in France, showing that this mycobacterium could be responsible for misleading bovine tuberculosis (bTB) diagnostic results (Michelet and o...
Source: Veterinary Record - Category: Veterinary Research Tags: Letter Source Type: research
AbstractHazardous practices regarding antibiotics misuse, unsanitary milking procedures, and the commercial sales of raw milk and unpasteurized dairy products are currently being practiced by livestock farmers in the Sumapaz region (Colombia). The purpose of this study was to screen for food-borne and zoonotic pathogens associated with local livestock practices. We evaluated 1098 cows from 46 livestock farms in the Sumapaz region that were selected by random. Of the total population of cattle, 962 animals (88%) were tested for bovine TB using a caudal-fold tuberculin test and 546 (50%) for brucellosis by a competitive ELIS...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
Funding Opportunity ID: 289713 Opportunity Number: RFA-CK-17-004 Opportunity Title: Determining and Monitoring Health Conditions Identified in the Medical Assessment of US-Bound RefugeesOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.084Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: Single Source Competition - International Organization for Migration (IOM)Agency ...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding
by Mahamat Fayiz Abakar, Hind Yahyaoui Azami, Philipp Justus Bless, Lisa Crump, Petra Lohmann, Mirjam Laager, Nakul Chitnis, Jakob Zinsstag Bovine tuberculosis (BTB) is an endemic zoonosis in Morocco caused byMycobacterium bovis, which infects many domestic animals and is transmitted to humans through consumption of raw milk or from contact with infected animals. The prevalence of BTB in Moroccan cattle is estimated at 18%, and 33% at the individual and the herd level respectively, but the humanM.bovis burden needs further clarification. The current control strategy based on test and slaughter should be improved through l...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
CONCLUSION: The Ag85B continuous expression within the host may generate a stronger and long-lasting immune response compared to conventional systems. PMID: 28177046 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
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