ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis

In this study, we found thatERAP1 andPDE8A were downregulated in vaccinated cattle that were protected from experimentalM. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.J Mol Microbiol Biotechnol 2017;27:237-245
Source: Journal of Molecular Microbiology and Biotechnology - Category: Microbiology Source Type: research

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In this study, we found thatERAP1 andPDE8A were downregulated in vaccinated cattle that were protected from experimentalM. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.J Mol Microbiol Biotechnol 2017;27:237-245
Source: Journal of Molecular Microbiology and Biotechnology - Category: Microbiology Source Type: research
In this study, we found thatERAP1 andPDE8A were downregulated in vaccinated cattle that were protected from experimentalM. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.J Mol Microbiol Biotechnol 2017;27:237-245
Source: Journal of Molecular Microbiology and Biotechnology - Category: Microbiology Source Type: research
Abstract Bovine tuberculosis (TB) caused by Mycobacterium bovis remains an important zoonotic disease posing a serious threat to livestock and wildlife. The current TB tests relying on cell-mediated and humoral immune responses in cattle have performance limitations. To identify new serodiagnostic markers of bovine TB, we screened a panel of 101 recombinant proteins, including 10 polyepitope fusions, by multi-antigen print immunoassay (MAPIA) with well-characterized serum samples serially collected from cattle with experimental or naturally acquired M. bovis infection. A novel set of 12 seroreactive antigens was e...
Source: Clinical and Vaccine Immunology - Category: Allergy & Immunology Authors: Tags: Clin Vaccine Immunol Source Type: research
In this study, we found thatERAP1 andPDE8A were downregulated in vaccinated cattle that were protected from experimentalM. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.J Mol Microbiol Biotechnol 2017;27:237-245
Source: Journal of Molecular Microbiology and Biotechnology - Category: Microbiology Source Type: research
Funding Opportunity ID: 289713 Opportunity Number: RFA-CK-17-004 Opportunity Title: Determining and Monitoring Health Conditions Identified in the Medical Assessment of US-Bound RefugeesOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.084Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: Single Source Competition - International Organization for Migration (IOM)Agency ...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding
CONCLUSION: The Ag85B continuous expression within the host may generate a stronger and long-lasting immune response compared to conventional systems. PMID: 28177046 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
In this study we characterized 10 NTM isolates originating from water, soil, nasal swabs of cattle and African buffalo as well as bovine tissue samples. These isolates were previously identified during an NTM survey and were all found, using 16S rDNA sequence analysis to be closely-related to Mycobacterium moriokaense. A polyphasic approach that includes phenotypic characterization, antibiotic susceptibility profiling, mycolic acid profiling and phylogenetic analysis of four gene loci, viz 16S rDNA, hsp65, sodA, and rpoB was employed to characterize these isolates. Sequence data analysis of the four gene loci revealed that...
Source: International Journal of Systematic and Evolutionary Microbiology - Category: Microbiology Authors: Tags: Int J Syst Evol Microbiol Source Type: research
CONCLUSIONS The urge to do something to help in an international medical crisis is understandable and admirable, but the adverse impacts reported by participants here – at every stage of deployment, suggest that preparedness for these missions needs improvement and at the very least, high risk missions should be limited to more seasoned and well trained (for conditions in the field) personnel. While volunteering for a medical mission during a health crisis can be very rewarding, both professionally and personally, it can also be very disruptive and impactful. All volunteers for high risk missions must be made fully a...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
by Aseem Pandey, Ana Cabello, Lavoisier Akoolo, Allison Rice-Ficht, Angela Arenas-Gamboa, David McMurray, Thomas A. Ficht, Paul de Figueiredo Vaccination of humans and animals with live attenuated organisms has proven to be an effective means of combatting some important infectious diseases. In fact, the 20th century witnessed tremendous improvements in human and animal health worldwide as a consequence of large-scale vaccination progra ms with live attenuated vaccines (LAVs). Here, we use the neglected zoonotic diseases brucellosis and bovine tuberculosis (BTb) caused byBrucella spp. andMycobacterium bovis (M.bovis), res...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Summary Bovine tuberculosis (bTB), caused by Mycobacterium bovis (M. bovis), is a serious re‐emerging disease in both animals and humans. The evolution of the Multi‐ and Extensively drug‐resistant M. bovis strains (MDR‐TB and XDR‐TB) represents a global threat to public health. Worldwide, the disease is responsible for great economic losses in the veterinary field, serious threat to the ecosystem, and about 3.1% of human TB cases, up to 16% in Tanzania. Only thorough investigation to understand the pathogen's epidemiology can help in controlling the disease and minimizing its threat. For this purpose, v...
Source: Zoonoses and Public Health - Category: Infectious Diseases Authors: Tags: Review Article Source Type: research
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