Central chemoreflex activation induces sympatho ‐excitation without altering static or dynamic baroreflex function in normal rats

In conclusion, central chemoreflex activation did not alter the transfer function of the mechanoneural, neuromechanical, or total arcs. Central chemoreflex modifies hemodynamics via sympatho‐excitation without compromising dynamic or static baroreflex AP buffering function.

We examine the impact of central chemoreflex activation on baroreflex function. Central chemoreflex activation induces sympatho‐excitation via upward resetting of the baroreflex mechanoneural arc, but does not alter the static or dynamic baroreflex function. Thus, central chemoreflex modifies hemodynamics by sympatho‐excitation without compromising baroreflex arterial pressure buffering function.

Source: Physiological Reports - September 12, 2017 Category: Physiology Authors: Keita Saku, Takeshi Tohyama, Masako Shinoda, Takuya Kishi, Kazuya Hosokawa, Takuya Nishikawa, Yasuhiro Oga, Takafumi Sakamoto, Hiroyuki Tsutsui, Tadayoshi Miyamoto, Kenji Sunagawa Tags: Original Research Source Type: research