A suspected case of autoinduction of voriconazole metabolism in a patient with cerebral aspergillosis

Source: Drug, Healthcare and Patient Safety - Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

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AbstractThe aim of this case series was to provide a modern cohort of patients with cerebral aspergillosis and show the effectiveness of modern treatment concepts. In a 10-year period from January 2009 to January 2019, we identified 10 patients (6 male, 4 female) who received surgery or frameless stereotactic drainage of a cerebral aspergilloma at our center. Patients ’ and disease characteristics were recorded. The median age was 65 (range 45 to 83). We conducted 133 cranial surgeries in 100 patients due to cerebral brain abscess (BA) during that time, which leads to a percentage of 10% of aspergilloma within BAs in...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
A 69-year-old man with newly diagnosed B-precursor acute lymphoblastic leukemia (B-ALL) had impaired consciousness (Glasgow coma scale [GCS] E4V4M6) on day 24 of remission induction therapy. Serum beta-D-glucan (61.0  pg/μL) and Aspergillus galactomannan antigens in the serum and cerebrospinal fluid (CSF) (both ≥5.0) were elevated. Computed tomography showed a nodule in the left lung. Magnetic resonance imaging (MRI) revealed multiple brain lesions, and brain biopsy confirmed aspergillosis (Fig. 1) accordin g to the updated invasive fungal disease definition (Donnelly et al., 2019).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Medical Imagery Source Type: research
Source: Annals of Hematology - Category: Hematology Source Type: research
nt JP PMID: 33021398 [PubMed - as supplied by publisher]
Source: Am J Respir Crit Car... - Category: Intensive Care Authors: Tags: Am J Respir Crit Care Med Source Type: research
Invasive fungal infections caused by Aspergillus (A.) and Mucorales species still represent life-threatening diseases in immunocompromised individuals, and deeper knowledge about fungal interactions with elements of innate immunity, such as complement and platelets, appears essential for optimized therapy. Previous studies showed that galactosaminogalactan secreted by A. fumigatus and A. flavus is deposited on platelets, thereby inducing their activation. Since the altered platelet surface is a putative trigger for complement activation, we aimed to study the interplay of platelets with complement in the presence of fungal...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractInvasive fungal infections incidence in patients with hematological malignancies is increasing. Air treatment remains an essential preventive measure. Guidelines state that high-risk patients should be housed in units equipped with High-Efficiency Particulate Air filtration. Mobile air-treatment devices may be considered as alternatives or as a complement to the ventilation system. We assessed the decontamination performances of a new mobile air-treatment device in a conventional hematology room. This device connected or not to a plenum combining Ultra-Low Particulate Air filtration and non-thermal catalysis proces...
Source: Health and Technology - Category: Information Technology Source Type: research
Conclusion: According to the results of this study, infected infants with congenital CMV infection could identify at early stage by testing Guthrie cards (within 21 days of life). Furthermore, since there is a lack of CMV knowledge in our population, educating and effective counseling by obstetricians/gynecologists to the pregnant women are recommended. PMID: 32994908 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
The coronavirus disease 2019 (COVID-19) virus caused a wide spectrum of disease in healthy individuals, as well as those with common comorbidities [1]. Severe COVID-19 is characterised by acute respiratory distress syndrome (ARDS) secondary to viral pneumonitis, treatment of which may require mechanical ventilation or extracorporeal membrane oxygenation [2]. Clinicians are alert to the possibility of bacterial co-infection as a complication of lower respiratory tract viral infection; for example, a recent review found that 72% of patients with COVID-19 received antimicrobial therapy [3]. However, the risk of fungal co-infe...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research
Isolated aspergillus laryngitis is rare and often diagnosed after surgical excision or biopsy for a suspected premalignant or malignant pathology. Unlike other systemic or localized aspergillosis, there are no specific guidelines for isolated laryngeal aspergillosis. Our experience of dealing with a wide variety of isolated laryngeal aspergillosis showed that this entity is very responsive to medical therapy, making extensive debridement (as often carried out in surgically accessible aspergillosis) unnecessary as it would invariably lead to long-term dysphonia.
Source: Journal of Voice - Category: ENT & OMF Authors: Source Type: research
Publication date: Available online 24 September 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chih-Cheng Lai, Weng-Liang Yu
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
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