Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort

Active smoking in stable COPD subjects significantly increased eosinophil accumulation in the distal airspaces, but not in sputum or peripheral blood. Our findings support the need to investigate this cell-type as a potential driver of COPD symptomatology and progression.

Source: Journal of Allergy and Clinical Immunology - September 12, 2017 Category: Allergy & Immunology Authors: Carlos H. Martinez, Sara X. Li, Andrew J. Hirzel, Valerie R. Stolberg, Neil E. Alexis, R. Graham Barr, Eugene R. Bleecker, Elizabeth E. Carretta, Stephanie A. Christenson, Christopher B. Cooper, David J. Couper, Claire M. Doerschuk, MeiLan K. Han, Nadia N Source Type: research