Post-Tuberculous Fibrosing Mediastinitis Post-Tuberculous Fibrosing Mediastinitis
This rare case provides insight into the link between tuberculosis and fibrosing mediastinitis, and discusses diagnostic and treatment strategies.BMJ Open Respiratory Research
‘ Remarkable progress ’ has been made, Unaids said, but millions more worldwide require treatment. Young women are especially hard hit.
Yale engineers are working to develop a novel method that could dramatically change how tuberculosis is diagnosed and treated.
The Loopamp ™MTBC detection kit (TB-LAMP) was designed to replace the sputum smear microscopy for the diagnosis of pulmonary tuberculosis. We evaluated its performance at a peripheral laboratory in Vietnam. The sensitivity of TB-LAMP was 45.5% [28.1% - 63.6%], which was equal to three-sputum smear microscopy but lower than that of Xpert MTB/RIF (87.8% [71.8% - 96.6%]). In patients with culture-confirmed TB, sensitivity was 80% [51.9% - 95.7%] in smear-positive and 16.7% [3.5% - 41.4%] in smear-negative cases.
In this study, we aimed to assess the accuracy and speed of the microscopic‐observation drug susceptibility (MODS) assay in the identification of MTBC and detection of multidrug resistance. Sputum samples from patients suspected to have tuberculosis were simultaneously tested with MODS and conventional culture [Löwenstein‐Jensen (LJ) culture, BACTEC MGIT™ 960 (MGIT) system], and drug susceptibility testing (MGIT system) methods. A total of 331 sputum samples were analyzed. Sensitivity and specificity of MODS assay for detection of MTBC strains were 96% and 98.8%, respectively. MODS assay detected multidrug r...