NK Cell Effector Functions Regulation by Modulating nTreg Cell Population During Progressive Growth of Dalton's Lymphoma in Mice.
NK Cell Effector Functions Regulation by Modulating nTreg Cell Population During Progressive Growth of Dalton's Lymphoma in Mice. Immunol Invest. 2017 Sep 11;:1-17 Authors: Tomar MS, Kumar S, Kumar S, Gautam PK, Singh RK, Verma PK, Singh SP, Acharya A Abstract Natural killer (NK) cells are large granular lymphocytes of the innate immune system and play a pivotal role against virus-infected cells, microbial pathogens, and tumor cells. NK cells secrete several cytokine,s but IFN-γ secreted by NK cells play a vital role in the activation of the innate and adaptive immune systems. But during any infection or tumor burden, functional activity of NK cells is downregulated significantly by nTreg cells. It is also found that during tumor progression, the number of nTreg cells increases as a result; it effectively suppresses the antitumor activity of NK cells. Therefore, in the present investigation, we intend to examine the mechanism of downregulation of antitumor immune response mediated by NK cells. We observed increased NK cell population at an early stage of Dalton's lymphoma (DL) growth, while at late stage, NK cell numbers were decreased. The NK cell functional activity was govern by high level of IFN-γ measurement during tumor progression. The FoxP3(+) CD25(+) CD4(+) T regulatory cell population was found to be continuously increased with high-level expression of FoxP3 during DL growth. The rapid increase in the number of Treg cells during DL p...
Authors: Legat FJ Abstract Phototherapy and photochemotherapy (PUVA) are important treatment modalities in inflammatory skin diseases such as psoriasis and atopic dermatitis as well as in cutaneous T‑cell lymphoma (e.g., mycosis fungoides/Sezary syndrome). Many of these skin diseases are accompanied by distracting pruritus. In addition, patients may suffer from intense pruritus in systemic diseases of the kidney and liver as well as of the endocrine and hematopoietic system. UV-light during phototherapy is capable of not only improving the inflammatory skin lesions but also of reducing the pruritus in skin and sy...
CONCLUSIONS: Absolute numbers of cases of HL at our centre have increased since the roll-out of antiretroviral therapy (ART) to the public sector. The recent change in policy to make ART available to all HIV-positive patients independent of CD4+ count suggests that patients will survive longer and are therefore at increased risk of developing HL. We anticipate that numbers of HL cases will increase or remain high in the coming years, and we need to prepare for this. PMID: 30004343 [PubMed - in process]
Conclusions: Taken together, this work demonstrated that miR-181b might have the ability to overcome chemo resistance of small cell lung cancer cells, and restoration of this miRNA may represent a potential therapeutic strategy for improving chemo sensitivity in small cell lung cancer. PMID: 30002690 [PubMed]
I read with interest the proposal of the European Organisation for Research and Treatment of Cancer (EORTC) cutaneous lymphoma task force concerning B ratings based on absolute counts of CD4+CD26 − or CD4+CD7− lymphocytes, that is, B0,
The comments on blood class in erythrodermic cutaneous T-cell lymphoma (CTCL) from E. Vonderheid are received with interest by our European Organisation for Research and Treatment of Cancer (EORTC) group. First, it should be noted that our recent EORTC consensus statement defined blood class according to flow cytometry  and included all patients with mycosis fungoides (MF) and Sezary syndrome (SS). E. Vonderheid commented on blood class in erythrodermic MF/SS, and it must be recognised that blood involvement is much more frequent in erythrodermic CTCL than patch, plaque and tumour stage MF p
To the editor,
In this report we present a patient with subcutaneous panniculitis-like T-cell lymphoma, who has been successfully treated with mycophenolate mofetil.
The predictive value of TP53 mutation (TP53mut) and complex karyotype (CK) was analyzed in 74 mantle cell lymphoma (MCL) patients. CK and TP53mut were predictors of inferior PFS and OS, independent of age and MIPI. The combination of TP53mut and CK status stratifies the patient population into three prognostic groups (p
Histiocytic sarcomas (HS) are rare neoplasms that generally behave aggressively, yet an in-depth look at the clinicopathologic features has not been studied. This paper explores 23 unique HS occurring as de novo or secondary malignancies. Patients with a secondary HS had lower mean survival by 58.2 months (p=0.001). This suggests secondary HS behaves more aggressively than de novo HS.
Lysosomal-associated membrane protein 1 (LAMP1) contributes to tumor metastatic potential and differentiation. We performed immunohistochemical staining to investigate LAMP1 expression levels in 122 diffuse large B cell lymphoma (DLBCL) tumor samples. LAMP1 expression was higher in DLBCL tissues compared with reactive hyperplasia tissues, which was independently associated with worse survivals. LAMP1 expression is associated with poor prognosis in DLBCL.