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UCLA receives $8.4 million NIH grant to help liver transplant recipients stay healthier longer

UCLA has received an $8.4 million grant from the National Institutes of Health to research ways to help donated livers last longer and improve outcomes for transplant recipients.The five-year grant is the fourth in a series from the NIH to the Dumont –UCLA Transplant Center to develop medications to prevent the body from rejecting a transplanted liver and help patients live longer, healthier lives. The grants have totaled more than $13 million.The initiative is headed by Dr. Jerzy Kupiec-Weglinski, the Paul I. Terasaki Chair in Surgery and vice chair of research at the Department of Surgery at the David Geffen School of Medicine at UCLA. The project brings together the expertise and experience of researchers from the UCLA departments of surgery, pathology and laboratory medicine, and microbiology, immunology and molecular genetics.UCLA HealthDr. Jerzy Kupiec-Weglinski“There are less than 10 program project grants in the country funded by the NIH that are related to organ transplantation, so this is a big deal,” Kupiec-Weglinski said. “Through this project, we believe we will develop novel therapeutic strategies that can be directly applied in transplant pa tients.”  Around 6,000 liver transplant surgeries are performed every year in the U.S., and UCLA ’s liver transplant program was the nation’s fourth busiest last year, according to the United Network for Organ Sharing. UCLA doctors performed 161 liver transplants in 2...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - Category: Hematology Source Type: research
This article reviews the research progress for gut microbial a lterations and liver transplantation. Especially, this work also evaluates research on the management of gut microbial alteration and the prediction of possible injuries utilizing microbial alteration during liver transplantation. In addition, we propose possible directions for research on gut micro bial alteration during liver transplantation and offer a hypothesis on the utilization of microbial alteration in liver transplantation. The aim is not only to predict perioperative injuries but also to function as a method of treatment or even inhibit the rejection...
Source: Frontiers of Medicine - Category: General Medicine Source Type: research
Researchers at Yokohama City University and Cincinnati Children’s Center for Stem Cell and Organoid Medicine have developed a large-scale method to produce bioengineered liver tissue from human induced pluripotent stem cells (iPSCs). The technique could provide viable, consistently produced liver transplants, offering hope to patients with liver disease. One of the limitations faced by scientists trying to grow certain human cells in the lab for therapeutic purposes is the need to include animal cells in the same environment to help the human cells grow. Such animal cells produce substances that could cause negative...
Source: Medgadget - Category: Medical Devices Authors: Tags: Genetics Materials Surgery Source Type: blogs
Two years after the diagnosis of cirrhotic-stage primary sclerosing cholangitis, a 41-year-old man underwent successful liver transplantation. Three months later he experienced progressive shortness of breath, chest pain, and episodes of exertional syncope. Of note, during the 2-year pretransplant period, the patient had no cardiac complaints, and an echocardiogram performed a few months before the liver transplantation was normal.Figure 1 demonstrates 2 electrocardiograms (ECGs) of the patient.Figure 1A was obtained before the liver transplantation, andFigure 1B was recorded 3 months after the liver transplantation, on de...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
Fibrodysplasia Ossificans Progressiva (FOP) is an ultrarare genetic disorder of progressive, disabling heterotopic ossification for which there is presently no definitive treatment. Several recent studies in genetic mouse models of FOP support involvement of the mechanistic target of rapamycin complex 1 (mTORC1) pathway in the pathophysiology of FOP and propose the repurposed use of rapamycin, an inhibitor of mTORC1 signaling in clinical trials for the management of FOP. Here we report two patients with the classic FOP mutation who received rapamycin —one for four months on a compassionate basis for treatment of acut...
Source: Bone - Category: Orthopaedics Authors: Tags: Review Article Source Type: research
We describe the case of a 42-year-old woman with tuberous sclerosis and recent renal transplantation who was critically ill due to pneumonia and had elevation of liver enzymes. She was found to have green refractile inclusions on peripheral blood smear on the third day of hospitalization. The patient improved rapidly with treatment and was discharged in 5  days. It appears that prognostic value of these inclusion bodies is doubtful. We also highlight the need to conduct further studies to clarify the link between hepatic injury and the presence of these inclusions.
Source: Journal of Hematopathology - Category: Pathology Source Type: research
Authors: Gholson CF, McDonald J, McMillan R Abstract Preview How many months of documented abstinence are required before a patient with alcoholic cirrhosis can be considered for liver transplantation? What is the role of liver transplantation as treatment for primary hepatocellular cancer? What are the possible causes of elevated liver enzyme levels following transplantation? Which patients with neurologic injury are potential organ donors? The authors answer these and other questions primary care physicians may have about this lifesaving procedure. PMID: 29219713 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
In conclusion, our study is the first to describe the fluctuating expression levels and dynamics of the cytoskeletal protein β-actin and its potential roles in the pathogenesis of acute rejection following rat liver transplantion. Our results enhance the understanding of the roles of CD8+ T lymphocytes during acute rejection and suggest that β-actin regulation leads to apoptosis. PMID: 29218087 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Calado RT, Clé DV Abstract Despite significant progress in transplantation by the addition of alternative hematopoietic stem cell sources, many patients with inherited bone marrow failure syndromes are still not eligible for a transplant. In addition, the availability of sequencing panels has significantly improved diagnosis by identifying cryptic inherited cases. Androgens are the main nontransplant therapy for bone marrow failure in dyskeratosis congenita and Fanconi anemia, reaching responses in up to 80% of cases. Danazol and oxymetholone are more commonly used, but virilization and liver toxici...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Abstract PURPOSE: In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after pediatric liver transplantation (LTx). METHOD: We performed prospective analysis of 74 children, at the media...
Source: Acta Biochim Pol - Category: Biochemistry Authors: Tags: Acta Biochim Pol Source Type: research
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