UCLA receives $8.4 million NIH grant to help liver transplant recipients stay healthier longer

UCLA has received an $8.4 million grant from the National Institutes of Health to research ways to help donated livers last longer and improve outcomes for transplant recipients.The five-year grant is the fourth in a series from the NIH to the Dumont –UCLA Transplant Center to develop medications to prevent the body from rejecting a transplanted liver and help patients live longer, healthier lives. The grants have totaled more than $13 million.The initiative is headed by Dr. Jerzy Kupiec-Weglinski, the Paul I. Terasaki Chair in Surgery and vice chair of research at the Department of Surgery at the David Geffen School of Medicine at UCLA. The project brings together the expertise and experience of researchers from the UCLA departments of surgery, pathology and laboratory medicine, and microbiology, immunology and molecular genetics.UCLA HealthDr. Jerzy Kupiec-Weglinski“There are less than 10 program project grants in the country funded by the NIH that are related to organ transplantation, so this is a big deal,” Kupiec-Weglinski said. “Through this project, we believe we will develop novel therapeutic strategies that can be directly applied in transplant pa tients.”  Around 6,000 liver transplant surgeries are performed every year in the U.S., and UCLA ’s liver transplant program was the nation’s fourth busiest last year, according to the United Network for Organ Sharing. UCLA doctors performed 161 liver transplants in 2...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Steven Featley, 23, from Stoke Ash in Suffolk, had his sixth liver transplant last year as part of a lifelong battle with rare condition biliary atresia, which he has had since he was six weeks old.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Steven Featley, 23, from Stoke Ash in Suffolk, had his sixth liver transplant last year as part of a lifelong battle with rare condition biliary atresia, which he has had since he was six weeks old.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CONCLUSION: The high incidence of Candida non-albicans in the ora l cavity of transplant patients with a long period of transplantation is warning to a more effective control of the health of these individuals, especially those with older age.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
ConclusionsThe paracaval portion of the liver protruded on the liver surface underneath the right diaphragm in one third of our participants. The paracaval vein can be a landmark for the boundary between the caudate lobe and the segment 7 or 8 in half of the cases.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Conclusion A velocity ratio>3 on DUS is a reliable finding for the diagnosis of BCS in children after split liver transplantation.
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
AbstractPurpose of ReviewTo provide a comprehensive review of the preoperative and operative considerations for the surgical management of hilar cholangiocarcinoma.Recent FindingsThe management of hilar cholangiocarcinoma has evolved over the past 20  years, with data from large institutional series emerging, which has influenced decisions regarding the need for preoperative biliary drainage, portal-vein embolization, extent of surgical resection, role of transplantation, and efficacy of adjuvant and palliative therapies.SummaryHepatectomy has become the standard of care for resectable hilar cholangiocarcinoma, while ...
Source: Current Surgery Reports - Category: Surgery Source Type: research
The changing frequency in the listing of patients with end-stage HCV-induced liver disease for transplant, and the improvement of the typically impaired post-transplant survival seen in these patients, can be taken as early and strong indicators of direct acting antiviral (DAA) therapy ’s positive impact on HCV-associated disease burden. The study by Crespo et al. compared the composition of the liver transplant waiting list and the early post-transplant survival in the years before and after the availability of DAAs.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Desk Source Type: research
Conclusion The ability of 18F-FDG PET/CT to detect extrahepatic disease before LT for NCLM is vital to establish LT as a treatment option.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
One of the major obstacles facing stem cell therapy is the limited number of functional stem cells available after transplantation due to the harsh microenvironment surrounding the damaged tissue. The aim of t...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
ConclusionsIn our experience, pirfenidone may be safely continued until lung transplantation. Only one patient in our series experienced impaired wound healing related to a surgical issue, even when pirfenidone was continued until lung transplantation. We found no evidence of impaired wound healing or airway complications after lung transplantation in patients who were treated with pirfenidone before lung transplantation.
Source: Multidisciplinary Respiratory Medicine - Category: Respiratory Medicine Source Type: research
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