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UCLA receives $8.4 million NIH grant to help liver transplant recipients stay healthier longer

UCLA has received an $8.4 million grant from the National Institutes of Health to research ways to help donated livers last longer and improve outcomes for transplant recipients.The five-year grant is the fourth in a series from the NIH to the Dumont –UCLA Transplant Center to develop medications to prevent the body from rejecting a transplanted liver and help patients live longer, healthier lives. The grants have totaled more than $13 million.The initiative is headed by Dr. Jerzy Kupiec-Weglinski, the Paul I. Terasaki Chair in Surgery and vice chair of research at the Department of Surgery at the David Geffen School of Medicine at UCLA. The project brings together the expertise and experience of researchers from the UCLA departments of surgery, pathology and laboratory medicine, and microbiology, immunology and molecular genetics.UCLA HealthDr. Jerzy Kupiec-Weglinski“There are less than 10 program project grants in the country funded by the NIH that are related to organ transplantation, so this is a big deal,” Kupiec-Weglinski said. “Through this project, we believe we will develop novel therapeutic strategies that can be directly applied in transplant pa tients.”  Around 6,000 liver transplant surgeries are performed every year in the U.S., and UCLA ’s liver transplant program was the nation’s fourth busiest last year, according to the United Network for Organ Sharing. UCLA doctors performed 161 liver transplants in 2...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
ABSTRACT The positive impact of delayed kidney transplantation (KT) on patient survival for combined liver‐KT (CLKT) has already been demonstrated by our group. The purpose of this study is to identify whether the quality of the kidneys (based on KDPI) or the delayed approach KT contributes to improved patient survival. 130 CLKT were performed between 2002‐2015; 69 with simultaneous KT (Group S) and 61 with delayed KT (Group D) (performed as a second operation with a mean cold ischemia time [CIT] of 50±15h). All patients were categorized according to the KDPI score; 1‐33%, 34‐66%, and 67‐99%. Recipient and...
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
Conclusion: The varied surgical approaches in the A2ALL centers offer a novel opportunity to compare disparate LDLT approaches. The choice to use higher biliary radicals on the recipient duct for reconstruction was associated with more BC, possibly secondary to devascularization and ischemia. The use of Roux‐en‐Y biliary reconstruction was associated with vascular complications (HAT and PVT). These results can be used to guide biliary reconstruction decisions in the setting of anatomic variants and inform further improvements in LDLT reconstructions. Ultimately, this information may contribute to a lower incidence of t...
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
Publication date: Available online 18 September 2017 Source:Molecular Genetics and Metabolism Author(s): Ayman W. El-Hattab, Ana Maria Zarante, Mohammed Almannai, Fernando Scaglia Mitochondrial diseases are a clinically and genetically heterogeneous group of disorders that result from dysfunction of the mitochondrial oxidative phosphorylation due to molecular defects in genes encoding mitochondrial proteins. Despite the advances in molecular and biochemical methodologies leading to better understanding of the etiology and mechanism of these diseases, there are still no satisfactory therapies available for mitochondrial di...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
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Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
In conclusion, PGG is a pangenotypic HCV entry inhibitor with high bioavailability. The low cost and wide availability of this compound make it a promising candidate for HCV combination therapies, and also emerging human pathogenic flaviviruses like ZIKV.
Source: Antiviral Therapy - Category: Virology Source Type: research
ANISH KOKA MD In an age where big data is king and doctors are urged to treat populations, the journey of one man still has much to tell us. This is a tale of a man named Joe. Joseph Carrigan was a bear of a man – though his wife would say he was more teddy than bear.  He loved guitar playing,  and camp horror movies.  Those who knew him well said he had a kind heart, a quick wit and loved cats. I knew none of these things when I met Joe in the Emergency Department on a Sunday afternoon.  I had been called because of an abnormal electrocardiogram – the ER team was worried he could be having ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
ANISH KOKA MD In an age where big data is king and doctors are urged to treat populations, the journey of one man still has much to tell us. This is a tale of a man named Joe. Joseph Carrigan was a bear of a man – though his wife would say he was more teddy than bear.  He loved guitar playing,  and camp horror movies.  Those who knew him well said he had a kind heart, a quick wit and loved cats. I knew none of these things when I met Joe in the Emergency Department on a Sunday afternoon.  I had been called because of an abnormal electrocardiogram – the ER team was worried he could be having ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Cardiac surgery High-risk Quality Reporting Source Type: blogs
Abstract BackgroundThe purpose of this study was to evaluate clinical characteristics, treatment, and survival of children, who were diagnosed with hepatoblastoma (HB) in their first 6 months of age, enrolled in the SIOPEL 2 and 3 protocols. MethodsSeventy‐nine patients, treated between 1994 and 2006, were analyzed after stratification into three age groups: 
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
ConclusionRecently, cross-sectional imaging assessment of diffuse liver diseases has gained momentum due to its ability to provide both anatomical and functional assessments of normal and abnormal tissues. Various imaging techniques are being employed to assess diffuse liver diseases including magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound (US). MRI has the ability to detect abnormal intracellular and molecular processes and tissue architecture. CT has a high spatial resolution, while US provides real-time imaging, is inexpensive, and readily available. We herein review current state-of-the-art ...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
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