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Mepolizumab Beneficial in COPD With Eosinophilic Phenotype

Lower annual rate of moderate, severe exacerbations for patients receiving 100 mg mepolizumab
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Internal Medicine, Allergy, Pharmacy, Pulmonology, Geriatrics, Conference News, Source Type: news

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This study refers to the “necessity-concerns framework” and examines the associations between beliefs about medicines and self-reported medication adherence in people with chronic obstructive lung disease. 402 patients (196 with asthma, 206 with COPD) participated in the study and completed a questionnaire comprising th e “Beliefs about Medicines-Questionnaire” (BMQ) and the “Medication Adherence Report Scale” (MARS). Multivariable logistic regression analyses with the BMQ-subscales as explanatory and the dichotomized MARS-score as dependent variable were computed for the asthma and the ...
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
Summary BackgroundPrevious studies have reached conflicting conclusions about the role of atopy as a risk factor for COPD. In part, this is attributable to variation in the definitions of airflow limitation and the treatment of people with asthma. ObjectiveTo establish whether there is any independent association between atopy and post‐bronchodilator airflow limitation in the general population aged 40 years and over. MethodsA cross‐sectional survey was conducted in a general population sample of 2415 people aged 40 years and over in Australia. A history of ever being diagnosed with asthma was elicited by questionnaire...
Source: Clinical and Experimental Allergy - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
(MedPage Today) -- Would be first once-daily LAMA delivered by nebulizer
Source: MedPage Today Allergy - Category: Allergy & Immunology Source Type: news
This study evaluated the prevalence of comorbidities potentially affecting device handling in asthma and/or COPD patients using SABAs, including albuterol multidose dry powder inhaler (MDPI), the only MDPI not requiring hand-breath coordination.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
The Salford Lung Study in Chronic Obstructive Pulmonary Disease (SLS COPD) compared the initiation of once-daily fluticasone furoate/vilanterol 100/25 μg (FF/VI) treatment versus continuation of usual care (UC). The annual rate of moderate or severe exacerbations was significantly lower for patients initiated on FF/VI compared with UC (Vestbo, NEJM 2016). We conducted a follow-up study to compare the experiences of patients completing SLS COPD, b y exacerbation rate and randomized treatment.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
On February 21, 2017, a European Respiratory Society research seminar held in Barcelona discussed how to best apply precision medicine to chronic airway diseases such as asthma and chronic obstructive pulmonary disease. It is now clear that both are complex and heterogeneous diseases, that often overlap and that both require individualised assessment and treatment. This paper summarises the presentations and discussions that took place during the seminar. Specifically, we discussed the need for a new taxonomy of human diseases, the role of different players in this scenario (exposome, genes, endotypes, phenotypes, biomarke...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking, Asthma and allergy Perspective Source Type: research
The term "precision medicine" has become very popular over recent years, fuelled by scientific as well as political perspectives. Despite its popularity, its exact meaning, and how it is different from other popular terms such as "stratified medicine", "targeted therapy" or "deep phenotyping" remains unclear. Commonly applied definitions focus on the stratification of patients, sometimes referred to as a novel taxonomy, and this is derived using large-scale data including clinical, lifestyle, genetic and further biomarker information, thus going beyond the classical "signs-and-s...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking, Asthma and allergy Reviews Source Type: research
(MedPage Today) -- This week's topics include predicting mortality in those with congestive heart failure, bystander CPR impact, best management of stable COPD, and NOACs and bleeding risk
Source: MedPage Today Allergy - Category: Allergy & Immunology Source Type: news
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways caused mainly by cigarette smoke exposure. COPD progression is marked by exacerbations of the disease, often associated with infections. Recent data show the involvement in COPD pathophysiology of interleukin (IL)-17 and IL-22, two cytokines that are important in the control of lung inflammation and infection. During the initiation and progression of the disease, increased IL-17 secretion causes neutrophil recruitment, leading to chronic inflammation, airways obstruction and emphysema. In the established phase of COPD, a defective...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking, Mechanisms of lung disease, Asthma and allergy Review Source Type: research
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