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Mepolizumab Beneficial in COPD With Eosinophilic Phenotype

Lower annual rate of moderate, severe exacerbations for patients receiving 100 mg mepolizumab
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Internal Medicine, Allergy, Pharmacy, Pulmonology, Geriatrics, Conference News, Source Type: news

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Conclusions LAMA or ICS/LABA combinations use was associated with a lower risk of acute exacerbation in patients with COPD and asthma in this study.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
(MedPage Today) -- Patients could benefit from regular monitoring for BMD, fracture risk
Source: MedPage Today Allergy - Category: Allergy & Immunology Source Type: news
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Source: Clinical and Experimental Allergy - Category: Allergy & Immunology Authors: Tags: Invited Review Source Type: research
Short-acting β2 agonists (SABA) are administered primarily using pressurized metered-dose inhalers (pMDIs). Albuterol multidose dry powder inhaler (MDPI; ProAir RespiClick®), a novel, breath-actuated device, eliminates hand-breath coordination required of pMDIs. A gap exists in understanding real-world differe nces in patients prior to receiving albuterol MDPI or SABA pMDI.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Many contributing factors have been implicated in allergic asthma exacerbations, including infection, pollution, ozone, and increasingly, chronic lung disorders such as cystic fibrosis (CF) and chronic obstructive pulmonary disorder (COPD). A method of allergen desensitization effective in these vulnerable and often immunocompromised populations is urgently needed for public health reduction of complications and deaths from allergic asthma.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Elevated PAI-1 levels are associated with worse outcomes in COPD. It is unknown whether elevated PAI-1 affects lung function, or risk of COPD / emphysema in healthy adults.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
To find useful biomarkers for a differential diagnosis between asthma and COPD, we evaluated NAGL (neutrophil gelatinase-associated lipocalin), sRAGE (soluble receptor for advanced glycosylation end products), and anti-elastin antibody.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Endothelial dysfunction and change in vascular permeability are key events in many allergic diseases including edema and chronic obstructive pulmonary disease (COPD). On the molecular level, mitochondrial dysfunction contributes to the elevation of reactive oxygen species (ROS), which can then destabilize mitochondrial membrane potential. Now, research demonstrates that aldehyde dehydrogenase 2 (ALDH2) could be an invaluable combatant against mitochondrial dysfunction. Human carriers possessing an inactive ALDH2 variant have been found to be more susceptible to COPD and asthma.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
It is not known how early lung function deficits occurs in smokers and when it shows signs of lack of reversibility, which would indicate risk of developing COPD.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
We report the effect of EDS-FLU on QoL as measured by the Rhinosinusitis Disability Index (RSDI).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
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