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Sex chromosome changes in leukemia: cytogenetics and molecular aspects.

CONCLUSION: The presence of these abnormalities can cause genetic instability in BM and result in the development of a malignant clone and progression of the disease. In addition, the evaluation of SCL together with the genes involved in these chromosomes can contribute to predict the disease prognosis as well as monitoring of malignancy. PMID: 28889783 [PubMed - as supplied by publisher]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research

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Publication date: Available online 22 September 2017 Source:Best Practice & Research Clinical Haematology Author(s): Jacob M. Rowe Numerous advances have been made in the biology and treatment of acute myeloid leukemia (AML) in 2017. These include the integration of the assessment of minimal residual disease (MRD) into clinical practice, the approval and near approval of new agents, improvement in therapy for older patients, and the development of a number of promising new agents, including IDH inhibitors, a Hedgehog signaling pathway inhibitor, and a histone deacetylase inhibitor. In addition, the concept of chemothe...
Source: Best Practice and Research Clinical Haematology - Category: Hematology Source Type: research
Conclusion A single-institutional retrospective analysis found no significant differences in outcomes using GCLAC or CLAG for rrAML patients, though formal comparisons should be performed in a randomized clinical trial. The cost of GCLAC was higher than CLAG which should be considered when evaluating salvage chemotherapy options.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Doctors say Helen Huynh will die without a transplant and while her sister is a perfect match, she's in Vietnam and can't get a temporary visa
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Conclusions The use of consolidative radiotherapy following high-dose chemotherapy and autologous stem cell transplantation for the treatment of relapsed or refractory DLBCL appears to significantly improve LRC. For patients with masses ≥2 cm following transplant there was also an improved 2-year PFS and OS. Prospective trials are needed to further identify the patients who would derive the most benefit from consolidative radiotherapy in the transplant setting.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Numerous advances have been made in the biology and treatment of acute myeloid leukemia (AML) in 2017. These include the integration of the assessment of minimal residual disease (MRD) into clinical practice, the approval and near approval of new agents, improvement in therapy for older patients, and the development of a number of promising new agents, including IDH inhibitors, a Hedgehog signaling pathway inhibitor, and a histone deacetylase inhibitor. In addition, the concept of chemotherapy manipulation is still valid and can increase efficacy in some AML populations, and transplant patterns have shifted, enabling more ...
Source: Best Practice and Research. Clinical Haematology - Category: Hematology Authors: Source Type: research
To evaluate the role of consolidative radiotherapy in patients undergoing high dose chemotherapy and autologous stem cell transplant for relapsed or refractory diffuse large B-cell lymphoma (DLBCL).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research
Summary We prospectively evaluated a multiplex real‐time PCR assay (SeptiFast, SF) in a cohort of patients undergoing allo‐BMT in comparison to an in‐house PCR method (IH‐PCR). Overall 847 blood samples (mean 8 samples/patient) from 104 patients with haematological malignancies were analysed. The majority of patients had acute leukaemia (62%) with a mean age of 52 years (54% female). Pathogens could be detected in 91 of 847 (11%) samples by SF compared to 38 of 205 (18.5%) samples by BC, and 57 of 847 (6.7%) samples by IH‐PCR. Coagulase‐negative staphylococci (n=41 in SF, n=29 in BC) were the most frequent...
Source: Mycoses - Category: Research Authors: Tags: ORIGINAL ARTICLE Source Type: research
• t(16;21) AML is an indication for allo-HSCT.• The TLS-ERG transcript levels reflected MRD and may predict relapse after HSCT.• The TLS-ERG transcript levels might guide effective intervention.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
• WT1 levels in bone marrow before and after HCT provide relevant prognostic information. WT1 levels at leukocyte recovery may be helpful to plan therapeutic strategies. Sustained bone marrow WT1 levels below 100 copies are associated with a favorable outcome.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Abstract Autologous stem cell transplantation (ASCT) is considered as standard of care in patients with multiple myeloma (MM) patients aged 65  years or younger. We analyzed data of 94 patients of plasma cell dyscrasias who underwent 95 autologous transplants at our institute from October 2003 to Aug 2016. Other than 76 patients of newly diagnosed multiple myeloma, we also transplanted two patients of POEMS syndrome, two patients of plasm a cell leukemia, three patients of concurrent light chain deposition disease, three patients of multifocal plasmacytomas, and eight patients of isolated light chain myeloma. One pati...
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
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