Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation

Rapid neutrophil differentiation is key to the immune response against invading bacteria. Here, Riffelmacher et  al. show that autophagy, the main recycling process in the cell, provides energy for neutrophil differentiation by degrading lipid droplets. This opens possible novel therapeutic avenues for the differentiation treatment of granulocytic leukemia.

Source: Immunity - September 12, 2017 Category: Allergy & Immunology Authors: Thomas Riffelmacher, Alexander Clarke, Felix C. Richter, Amanda Stranks, Sumeet Pandey, Sara Danielli, Philip Hublitz, Zhanru Yu, Errin Johnson, Tobias Schwerd, James McCullagh, Holm Uhlig, Sten Eirik W. Jacobsen, Anna Katharina Simon Tags: Article Source Type: research