Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development

Understanding the molecular basis for the development of HIV Env-specific bnAbs is key for vaccine design. Andrabi et  al. find that CAP256 V2 apex lineage Abs affinity mature with sialic acid containing complex-type glycans on HIV envelope trimer. This glycan recognition enables the development into bnAbs by resisting virus escape.

Source: Immunity - September 12, 2017 Category: Allergy & Immunology Authors: Raiees Andrabi, Ching-Yao Su, Chi-Hui Liang, Sachin S. Shivatare, Bryan Briney, James E. Voss, Salar Khan Nawazi, Chung-Yi Wu, Chi-Huey Wong, Dennis R. Burton Tags: Article Source Type: research