SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Extracellular double-stranded RNA is predominantly sensed by cytosolic RLRs after endocytic uptake, but how it enters the cytoplasm is unknown. Nguyen and colleagues demonstrate that the endo-lysosomal protein SIDT2 transports double-stranded RNA into the cytoplasm for RLR signaling and is required for survival after EMCV infection.

Source: Immunity - September 12, 2017 Category: Allergy & Immunology Authors: Tan A. Nguyen, Blake R.C. Smith, Michelle D. Tate, Gabrielle T. Belz, Marilou H. Barrios, Kirstin D. Elgass, Alexandra S. Weisman, Paul J. Baker, Simon P. Preston, Lachlan Whitehead, Alexandra Garnham, Rachel J. Lundie, Gordon K. Smyth, Marc Pellegrini, M Tags: Article Source Type: research