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Why Hormone Replacement Therapy May Be Safer Than You Think

The pendulum has swung from one extreme to the other when it comes to hormone replacement therapy (HRT) to treat symptoms of menopause. At first, the replacement hormones—mostly a combination of estrogen and progestin to replace what the body stops making after menopause—were seen as a panacea. Doctors thought they could not only relieve hot flashes and night sweats, but also prevent chronic aging diseases like heart problems and weakening bones. But studies then found that the supplement hormones could lead to a higher risk of breast cancer—and that they didn’t protect the heart after all. In the latest study on the subject, published in JAMA, researchers led by Dr. JoAnn Manson from the division of preventive medicine at Brigham and Women’s Hospital report on the longest follow-up of the original hormone therapy study, which used data from the Women’s Health Initiative. More than 27,000 women who were randomly assigned to receive either a placebo, a combination of hormones (estrogen plus progestin) or estrogen alone if they had had a hysterectomy. They were followed for 18 years and tracked for chronic diseases like cancer, as well as heart attack and deaths. The women took the hormone therapy for five to seven years. By the end of the 18-year study, the death rates from any cause among the women receiving some form of hormone therapy were similar to that of women who took the placebo. MORE: Hormone Replacement Therapy After Menopause: W...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Drugs estrogen Hormone Therapy hormones for menopause hot flashes night sweats progestin Reproductive Health treating menopause Source Type: news

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CONCLUSION: these results support the use of evolocumab as add-on therapy to statins for high cardiac-risk patients not achieving optimal goals of LDL-C. Longer-term studies are needed to further clarify the efficacy and safety of evolocumab. PMID: 28925859 [PubMed - as supplied by publisher]
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
Abstract BackgroundCigarette smoking has been identified as a major modifiable risk factor for coronary heart disease and mortality. However, findings on the relationship between smoking and atrial fibrillation (AF) have been inconsistent. Furthermore, findings from previous studies were based on self‐reported smoking. ObjectiveTo examine the associations of smoking status and plasma cotinine levels, a marker of nicotine exposure, with risk of incident AF in the Hordaland Health Study. MethodsWe conducted a prospective analysis of 6682 adults aged 46‐74 years without known AF at baseline. Participants were followed via...
Source: Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Original Article Source Type: research
Abstract ObjectiveTo assess the effect of lymph node dissection (LND), number of removed nodes (NRN) and number of positive nodes (NPN) on cancer specific mortality (CSM), in contemporary vs. historical patients, with pT2‐3NanyM0 renal cell carcinoma (RCC) treated with radical nephrectomy (RN). MethodsWithin the SEER database (2001‐2013), we identified patients with non‐metastatic pT2‐3 Nany RCC who underwent RN with or without LND. Kaplan–Meier analyses and multivariable Cox regression models with propensity score weighting for inverse probability of treatment were used. ResultsOf 25,357 patients, 24.8% unde...
Source: BJU International - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
A new UCLA study has found that healthy nonsmokers experienced increased adrenaline levels in their hearts after one electronic cigarette with nicotine.Thefindings are published in  Journal of the American Heart Association,  the open access journal of the American Heart Association/American Stroke Association.Unlike cigarettes, e-cigarettes, also known as e-cigs, have no combustion or tobacco. Instead, these electronic, handheld devices deliver nicotine with flavoring and other chemicals in a vapor rather than smoke.“While e-cigarettes typically deliver fewer carcinogens than are found in the tar of tobacc...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
The Seattle-based biotech offered a rare look at the high-tech process behind its CAR-T immunotherapy cancer treatment.
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
Abstract Oesophageal squamous cell carcinomas and oesophageal adenocarcinomas display distinct patterns of ErbB expression and dimers. The functional effects of specific ErbB homo‐ or heterodimers on oesophageal (cancer) cell behaviour, particularly invasion of early carcinogenesis remains unknown. Here, a new cellular model system for controlled activation of EGFR or HER2 and EGFR/HER2 or HER2/HER3 homo‐ and heterodimers was studied in non‐neoplastic squamous oesophageal epithelial Het‐1A cells. EGFR, HER2 and HER3 intracellular domains (ICDs) were fused to dimerization domains (DmrA / DmrA and DmrC), and transduc...
Source: The Journal of Pathology - Category: Pathology Authors: Tags: Original Paper Source Type: research
Jake LaMotta, the former middleweight boxing champion who died Wednesday at age 95 from complications from pneumonia, handed Sugar Ray Robinson, the man that many sweaty scholars of the sweet science consider the best pound-for-pound fighter of all-time, his first-ever loss. His bouts with Robinson defined boxing in the 1940s and 1950s, an era when the sport soared in popularity. LaMotta’s combustable life, both inside and outside the ring, were brilliantly captured in Raging Bull, the 1980 Martin Scorsese film that won Robert De Niro, who portrayed LaMotta, an Oscar, and is recognized as one of the best and most inf...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Boxing Jake LaMotta martin scorsese Oscar Raging Bull Robert De Niro Sugar Ray Robinson Source Type: news
Abstract Surgery remains the mainstay of treatment for colon and rectal cancers. Colon cancer outcomes have improved with laparoscopic techniques, enhanced recovery pathways, and adjuvant chemotherapy. Adjuvant 5-fluorouracil with or without oxaliplatin in stage III and possibly high-risk stage II colon cancer is associated with improved survival. Multimodality management of rectal cancer continues to evolve; total mesorectal excision is the cornerstone. Oncologic results do not support the use of laparoscopic resection in rectal cancer. Preoperative short- or long-course radiation for stage II or III rectal ...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Surg Oncol Clin N Am Source Type: research
This article reviews recent high-quality randomized clinical trials that were conducted to address optimal treatment of advanced and metastatic colorectal carcinoma, mainly focused on initially inoperable metastatic disease. PMID: 28923224 [PubMed - in process]
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Surg Oncol Clin N Am Source Type: research
CONCLUSIONS: For people with advanced cancer, engagement in occupation influences their self as current abilities become apparent and positions of their self can be created and expressed. PMID: 28922981 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
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