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Why Hormone Replacement Therapy May Be Safer Than You Think

The pendulum has swung from one extreme to the other when it comes to hormone replacement therapy (HRT) to treat symptoms of menopause. At first, the replacement hormones—mostly a combination of estrogen and progestin to replace what the body stops making after menopause—were seen as a panacea. Doctors thought they could not only relieve hot flashes and night sweats, but also prevent chronic aging diseases like heart problems and weakening bones. But studies then found that the supplement hormones could lead to a higher risk of breast cancer—and that they didn’t protect the heart after all. In the latest study on the subject, published in JAMA, researchers led by Dr. JoAnn Manson from the division of preventive medicine at Brigham and Women’s Hospital report on the longest follow-up of the original hormone therapy study, which used data from the Women’s Health Initiative. More than 27,000 women who were randomly assigned to receive either a placebo, a combination of hormones (estrogen plus progestin) or estrogen alone if they had had a hysterectomy. They were followed for 18 years and tracked for chronic diseases like cancer, as well as heart attack and deaths. The women took the hormone therapy for five to seven years. By the end of the 18-year study, the death rates from any cause among the women receiving some form of hormone therapy were similar to that of women who took the placebo. MORE: Hormone Replacement Therapy After Menopause: W...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Drugs estrogen Hormone Therapy hormones for menopause hot flashes night sweats progestin Reproductive Health treating menopause Source Type: news

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Low alanine aminotransferase (ALT) blood levels are associated with frailty and poor outcome in older adults. Therefore, we studied the association between ALT blood levels before rehabilitation and rehabilitation outcome in older adults following hip fracture surgery. A total of 490 older adults (age>60 years, mean age: 82.9±6.7 years, 82.0% women) admitted to rehabilitation following hip fracture surgery were included. The rehabilitation outcome was assessed by Functional Independence Measure (FIM) scores. ALT blood levels were documented between 1 and 6 months before rehabilitation. Patients with ALT blood lev...
Source: International Journal of Rehabilitation Research - Category: Rehabilitation Tags: Original articles Source Type: research
Definitive treatment options for localized prostate cancer (PCa) include radical prostatectomy, cryotherapy, and radiation therapy. In patients with higher risk disease, radiation therapy is combined with androgen deprivation therapy. Active surveillance is reasonable for men with low-risk disease, especially in patients who are older or have associated comorbid conditions. Although the paradigm for treatment of the primary tumor in locally advanced or metastatic disease is slowly changing, androgen deprivation therapy remains fundamental in the management of these patients.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Commentary Source Type: research
The abscopal effect, whereby localized treatment to 1 tumor results in destruction of other untreated sites, is a rare phenomenon, described primarily in case reports. In melanoma, by combining treatments that augment the immune response with interventions (e.g., external-beam radiotherapy) that produce tumor antigens and danger signals from cell death, the abscopal effect can be triggered in as many as 25% of patients (1). In the context of metastatic breast cancer (MBC), abscopal effects have been reported in preclinical studies but not in human patients.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
PROSTATE cancer symptoms include urinating more often than usual and feeling like your bladder isn ’t ever entirely empty. You should always see a doctor if you’re showing signs of the cancer, but what should you expect, and how can you test for prostate cancer?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Narelle Krikhoff, 53, from Brisbane, who only started wearing suncream at 20 years old, had part of her nose removed after doctor discovered the mark on her nose was actually a cancerous lump.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Ultra-processed foods have been linked to cancer - so should we be worried about eating bread?
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
US Army nurse and first female general in US Armed Forces. She was born in Buffalo, NY, USA, on Feb 16, 1920, and died following a heart attack in Washington, DC, USA, on Jan 7, 2018, aged 97 years.
Source: LANCET - Category: General Medicine Authors: Tags: Obituary Source Type: research
Conclusion: Elevated preoperative intraplatelet VEGF and PDGF levels in CRC patients suggest new possibilities for postoperative monitoring in CRC patients, especially when CEA is negative.Gastrointest Tumors
Source: Gastrointestinal Tumors - Category: Gastroenterology Source Type: research
Authors: Zhang C, Deng Y, Lei Y, Zhao J, Wei W, Li Y PMID: 29442482 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Authors: Park HJ PMID: 29441749 [PubMed]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
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