Why Hormone Replacement Therapy May Be Safer Than You Think

The pendulum has swung from one extreme to the other when it comes to hormone replacement therapy (HRT) to treat symptoms of menopause. At first, the replacement hormones—mostly a combination of estrogen and progestin to replace what the body stops making after menopause—were seen as a panacea. Doctors thought they could not only relieve hot flashes and night sweats, but also prevent chronic aging diseases like heart problems and weakening bones. But studies then found that the supplement hormones could lead to a higher risk of breast cancer—and that they didn’t protect the heart after all. In the latest study on the subject, published in JAMA, researchers led by Dr. JoAnn Manson from the division of preventive medicine at Brigham and Women’s Hospital report on the longest follow-up of the original hormone therapy study, which used data from the Women’s Health Initiative. More than 27,000 women who were randomly assigned to receive either a placebo, a combination of hormones (estrogen plus progestin) or estrogen alone if they had had a hysterectomy. They were followed for 18 years and tracked for chronic diseases like cancer, as well as heart attack and deaths. The women took the hormone therapy for five to seven years. By the end of the 18-year study, the death rates from any cause among the women receiving some form of hormone therapy were similar to that of women who took the placebo. MORE: Hormone Replacement Therapy After Menopause: W...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Drugs estrogen Hormone Therapy hormones for menopause hot flashes night sweats progestin Reproductive Health treating menopause Source Type: news

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CONCLUSION: Significant increases in use of THA and TKA are expected in the United States in the future, if the current trend continues. The increased use is evident across age groups in both females and males. A policy change may be needed to meet increased demand. PMID: 30988126 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
CONCLUSION: Bacteremia occurred mostly in active SLE patients and was frequently associated with severe flares and corticosteroid use. Recurrence and mortality were high. Immunosuppressors, comorbidities and disease-related damage were associated with bacteremia. PMID: 30988123 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Publication date: Available online 16 April 2019Source: Journal of Molecular StructureAuthor(s): A. Sunil Kumar, Jyothi Kudva, Manu Lahtinern, Anssi Peuronen, Rajitha Sadashiva, Damodara NaralAbstractThree quinazolin-4-ylamino derivatives containing phenylbenzenesulfonamides (7a-7c) were synthesized by reacting (E)-N'-(2-cyanophenyl)-N,N-dimethyl formamidine (6) with different 4-amino-N-(phenyl)benzenesulfonamides (4a-4c) and characterized by different techniques such as HRMS, IR, 1H NMR and 13C NMR spectroscopy. The structural properties were further examined by single crystal X-ray diffraction method. The X-ray data show...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00651F, PaperAgata Campisi, Maria Assunta Chiacchio, Laura Legnani, Paola Bottino, Giuseppe Lanza, Daniela Iannazzo, Lucia Veltri, Salvatore V. Giofr è, Roberto ROMEO A series of 2,3,4-triaryl-substituted 1,2,4-oxadiazole-5-ones have been prepared as fixed-ring analogues of tamoxifen (TAM), a drug inhibitor of Estradiol Receptor (ER) used in breast cancer therapy, by an efficient synthetic... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
CONCLUSIONS: All riders should wear a certified helmet and replace it after sustaining a head impact. Following an impact, expanded polystyrene liners compress, and their ability to attenuate head acceleration during subsequent impacts to the same location is reduced. Replacing an impacted helmet may reduce a rider's head injury risk. PMID: 30987519 [PubMed - as supplied by publisher]
Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
Publication date: Available online 17 April 2019Source: Life SciencesAuthor(s): Andrew Kisling, Robert M. Lust, Laxmansa C. KatwaAbstractCollagen is the most abundant protein in mammalian systems; it can be found in organs such as bones, the liver, kidney, heart, teeth, and skin. Collagen provides the necessary structural framework for tissues in which it is found. However, if there are any alterations in the delicate balance of collagen types in the extracellular matrix (ECM), then problems arise. For example, increasing collagen I:III ratio would provide additional rigidity to tissue structure, whereas decreasing this ra...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 17 April 2019Source: Life SciencesAuthor(s): Biao Yu, Mingjun Zhang, Jiahuan Chen, Lingyu Wang, Xiaohuan Peng, Xinwei Zhang, He Wang, Anbei Wang, Dazhong Zhao, Daxin Pang, Hongsheng OuYang, Xiaochun TangAbstractAimsColorectal cancer syndrome has been one of the greatest concerns in the world. Although several epidemiological studies have shown that hepatic low lipoprotein lipase (LPL) mRNA expression may be associated with dyslipidemia and tumor progression, it is still not known whether the liver plays an essential role in hyperlipidemia of ApcMin/+ mice.Main methodsWe measured the expre...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 17 April 2019Source: Life SciencesAuthor(s): Songyi Cheng, Xiaoxiao Zhang, Qian Feng, Jiandong Chen, Le Shen, Peng Yu, Li Yang, Daohai Chen, Haowen Zhang, Weixin Sun, Xiaohu ChenAbstractAims and methodsAcute myocardial infarction (AMI) is a common cardiovascular disease with high mortality. Astragaloside IV (AS-IV) was reported to have cardioprotective effect after AMI. We hypothesize that the cardioprotective role of AS-IV is exerted by enhancing angiogenesis via regulating PTEN/PI3K/Akt signaling pathway. To valid our hypothesis, AMI rats and human umbilical vein endothelial cells (HUVE...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 17 April 2019Source: Life SciencesAuthor(s): Anand Thirupathi, Yan-Zhong ChangAbstractThe gradual energy dissipation of all organisms allows adapting to energy demands. Pathological situations of uncured diseases such as cancer, diabetes, and other obesity-related diseases are caused by an abrupt energy imbalance. As an energy sensor, AMP-activated kinase (AMPK) can regulate the cellular energy status. In case of increased energy demands or insufficient nutrient supply, cells digest their own interior, which is called autophagy. AMPK-mediated autophagy regulates various metabolic and phys...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 16 April 2019Source: Life SciencesAuthor(s): Sha-sha Wang, Ya-ling Tang, Xin Pang, Min Zheng, Ya-jie Tang, Xin-hua LiangAbstractOral epithelial barrier consists of closely controlled structure of the stratified squamous epithelium, which is the gateway to human bodies and encounters a huge burden of microbial, airborne and dietary antigens, as well as masticatory damage. Once this barrier is destroyed, it will trigger bone loss, tissue damage and microbial dysbiosis and lead to diseases, such as periodontitis, oral mucosal diseases and oral cancer. Recently, increasing evidences showed th...
Source: Life Sciences - Category: Biology Source Type: research
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