​Trial fail for Cambridge-based Sage casts doubt on lead drug

Sage Therapeutics reported Tuesday morning that its drug to treat a severe and life-threatening form of epilepsy failed to meet the main goal of a late-stage trial. As of 6:50 a.m. Tuesday, Sage's shares were down 24 percent. If the drop holds until stocks open at 9:30 it would shave nearly $1 billion off the company's market capitalization. Cambridge-based Sage (Nasdaq: SAGE), which had 135 employees as of February, was testing its lead drug, called rexanol one, plus the current standard treatments…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Discussion Sleep disorders are common in all ages particularly sleep deprivation in our increasingly busy world. A review of health problems caused by inadequate sleep can be found here. Sleep problems are more common in patients with attention deficit hyperactivity disorder, epilepsy, headache and visual impairments. Sleep problems can cause cognitive and behavioral impairments including emotional regulation problems, increased seizures or headaches, and impaired attention and has been known to prolong recovery from various acquired brain injuries. Somnambulism or sleepwalking is a parasomnia (which include confusional a...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
GW Pharmaceuticals said regulators could approve Epidiolex as early as this week
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
Publication date: 2018 Source:Respiratory Medicine Case Reports, Volume 25 Author(s): Yonas Raru, Fuad Zeid Valproic acid (VPA) is widely used for the treatment of epilepsy, migraine, and a variety of psychiatric symptoms, including bipolar disorder, borderline personality disorder, and alcohol withdrawal. Valproate is associated with severe idiosyncratic adverse effects, the most notable being valproate-induced hyperammonemic encephalopathy (VHE). Topiramate is also a broad-spectrum anticonvulsant that is also extensively used for migraine prophylaxis, as a mood stabilizer, and for alcohol dependency. There is increased ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Localization of the epileptogenic zone (EZ) in patients with drug-resistant epilepsy undergoing presurgical evaluation is crucial for successful outcome and usually requires multiple investigations. It has been described that seizure activity is associated with transient focal increased cerebral blood flow in the involved cortical region (Horsley, 1892, Penfield, 1939). Subtraction ictal single-photon emission computed tomography (SPECT) co-registered to magnetic resonance imaging (SISCOM), which demonstrates regional differences in cerebral blood flow based on a differential between ictal and interictal perfusion imaging,...
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
The UK government is reviewing medicinal cannabis after two boys with severe epilepsy were withheld cannabis oil treatments. Here's everything you need to know
Source: New Scientist - Health - Category: Consumer Health News Tags: drugs health Source Type: research
Authors: Ham AT, Mackey J, Semb G Abstract Continuous electroencephalography (CEEG) is chiefly performed at The Medical University of South Carolina (MUSC) for identifying seizures, including its refined use within the epilepsy monitoring unit (EMU) as a differentiator between epileptic and psychogenic etiologies. CEEG also provides critical data that carry implications outside the bounds of both epilepsy and psychogenic events, such as the characterization of unorthodox clinical phenomena that are of physiological (though nonepileptic) origins. Although nonepileptic events (NEEs) are primarily linked with psychoge...
Source: The Neurodiagnostic Journal - Category: Neurology Tags: Neurodiagn J Source Type: research
Authors: Martins CHT, Assunção CM Abstract It is a fundamental element in both research and clinical applications of electroencephalography to know the frequency composition of brain electrical activity. The quantitative analysis of brain electrical activity uses computer resources to evaluate the electroencephalography and allows quantification of the data. The contribution of the quantitative perspective is unique, since conventional electroencephalography based on the visual examination of the tracing is not as objective. A systematic review was performed on the MEDLINE database in October 2017. Th...
Source: The Neurodiagnostic Journal - Category: Neurology Tags: Neurodiagn J Source Type: research
This study aimed to assess alcohol consumption and the occurrence of alcohol-related seizures in patients with epilepsy within the last 12 months. Methods: In an epilepsy outpatient clinic, a standardized questionnaire was used to co...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Conclusion: Longer duration SEDs exhibit CFC features similar to those reported by our team. Significance: First, Identifying the exponential relationship between network excitability and SED durations; second, highlighting the importance of glia in hyperexcitability (- s they relate to extracellular potassium); and third, elucidation of the biophysical basis for CFC coupling features.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Transcutaneous vagus nerve stimulation (tVNS) is a relatively new technique (Ventureyra 2000), which was developed to pose an alternative to direct or invasive vagus nerve stimulation (iVNS) for the treatment of drug-refractory epilepsy, depression and other disorders (Hein et al. 2013; Lehtim äki et al. 2013; Bauer et al. 2016). In contrast to iVNS, where a stimulation lead is surgically wrapped around the vagus nerve in the neck, tVNS can be applied to different locations of the outer ear innervated by the auricular branch of the vagus nerve, mostly the cymba conchae or the tragus thro ugh electrodes attached to the skin (Kraus et al.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
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