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​Trial fail for Cambridge-based Sage casts doubt on lead drug

Sage Therapeutics reported Tuesday morning that its drug to treat a severe and life-threatening form of epilepsy failed to meet the main goal of a late-stage trial. As of 6:50 a.m. Tuesday, Sage's shares were down 24 percent. If the drop holds until stocks open at 9:30 it would shave nearly $1 billion off the company's market capitalization. Cambridge-based Sage (Nasdaq: SAGE), which had 135 employees as of February, was testing its lead drug, called rexanol one, plus the current standard treatments…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Summary This review aims to highlight key considerations when performing cortico‐cortical evoked potentials (CCEPs) using stereo–electroencephalography (SEEG) for network mapping and show its clinical applicability to presurgical evaluations. The parameters for performing stimulation and safety aspects have been investigated in electrocorticography (ECoG) and deep brain stimulation (DBS), but not as extensively in SEEG. A review of current literature was performed, with an attempt made to emphasize practical insights from all modalities of intracranial stimulation. This paper reviews physical stimulation parameters...
Source: Epilepsia - Category: Neurology Authors: Tags: CRITICAL REVIEW AND INVITED COMMENTARY Source Type: research
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Invited Editorial Source Type: research
Epilepsy is one of the most common primary brain disorders. Nonparaneoplastic autoimmune encephalitis is increasingly recognized as an important cause of adult onset epilepsy. However, only in rare cases an initiating factor of the syndrome can be identified. Autoantibody detection after central nervous herpesvirus infection indicates a postviral etiology in a subgroup of patients. In order to analyze a possible underrecognition of postinfectious autoimmunity we performed a large-scale analysis of herpesvirus DNA in cerebrospinal fluid samples from patients with clinical signs of autoimmune encephalitis.
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Short communication Source Type: research
Conclusions There is evidence that the genetic abnormality responsible for familial temporal epilepsy had probably appeared considerably earlier than hitherto thought
Source: Seizure - Category: Neurology Source Type: research
For the ∼1/3 of epilepsy patients who are not controlled by medications alone, epilepsy surgery or the possibility of implantable devices to treat their seizures may be the only therapeutic option. However, the success rates of epilepsy surgery vary broadly from 40-80%(Cohen-Gadol et al., 2006; Lee et al. , 2005; Mohammed et al., 2012; de Tisi et al., 2011), and these numbers have not changed in many years. It is clear that the standard practice of evaluating epilepsy surgical candidates needs improvement.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
(Natural News) A group of 28 researchers, scientists and other experts in the neurotechnology field is calling for ethical rules when it comes to the brain-computer interface. Artificial intelligence technology brings with it the possibility of profoundly restoring the quality of life for many individuals suffering from brain injuries, blindness, paralysis, epilepsy, and other serious conditions....
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
CONCLUSIONS: The two abbreviated methods can be used in both the active and the remission phases, with a substantial reduction in the analysis time that is needed. Our results support the current tendency to consider SWI> 60% as suggestive of CSWS. Method M2 yields results that are closer to those of the classic method than those of M3. PMID: 29130467 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
We examined E‐S plasticity in chronically epileptic Sprague–Dawley rats 3–10 weeks after pilocarpine‐induced status epilepticus. CA1 neurons in hippocampal slices were assayed by whole‐cell current clamp to measure EPSPs evoked by Schaffer collateral stimulation. Using a weak spike‐timing‐dependent protocol to induce plasticity, we found robust E‐S potentiation in conjunction with weak long‐term potentiation (LTP) in saline‐treated rats. In pilocarpine‐treated rats, a similar degree of LTP was found, but E‐S potentiation was reduced. Additionally, the degree of E‐S potentiation was no...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
Idiopathic epilepsy is one of the most common neurological disorders in dogs. Unfortunately, up to 30% of dogs with idiopathic epilepsy show no improvement under antiepileptic drug treatment. Diffusion-weighte...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research article Source Type: research
Circadian CLOCK gene expression is reduced in human epileptic brain tissue, and its deletion is epileptogenic in mice.
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Editors ' Choice Source Type: research
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