Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice

Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to...

Source: BMC Musculoskeletal Disorders - September 11, 2017 Category: Orthopaedics Authors: Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Kohei Tatsumi, Masayoshi Ishida, Katsumi Okumoto, Osamu Matsuo, Masao Akagi and Hiroshi Kaji Tags: Research article Source Type: research