Effect of the cellular and humoral immune response in infertile couples and its relationship with infections.
[Effect of the cellular and humoral immune response in infertile couples and its relationship with infections.] Arch Esp Urol. 2017 Sep;70(7):662-668 Authors: Brufman A, Colombo L, Streiger E, Pusillico R Abstract OBJECTIVE: The purpose of this study was to determine the prevalence of different microorganisms isolated from the urogenital tract of infertile men and assess whether there are differences in semen parameters according to the presence or absence of genital infections. METHODS: 280 semen samples from infertile men were studied retrospectively. Semen parameters were analyzed according to the World Health Organization criteria (WHO 2010). Microbiological analysis was performed using the modified method of Stamey and Meares proposed by Santoianni et al. RESULTS: Microbiological studies showed absence of microorganisms or presence of usual colonizing flora in 67.86% of the samples (GROUP 1) and presence of at least one pathogen or potential pathogen in 32.14% (GROUP 2). No significant differences in ejaculate volume (p=0.353), pH value (p=0.801), motility (p>0.30), citric acid concentration (p=0.383) and viscosity (p=0.948) were observed between the two groups. The relative sperm count was significantly lower in infected patients than in those without pathogens (p=0.05). Teratozoospermia index (TZI) was evaluated. Samples of infected patients showed TZI values higher than patients without microorganisms or normal genital tract flora (p
CONCLUSION: Available evidence showed that curcumin has the potential to induce and maintain remission in UC patients with no serious side effects. However, further studies with larger sample size are needed to recommend it as adjuvant therapy of ulcerative colitis. PMID: 29348389 [PubMed - in process]
(American Society of Plant Biologists) Fanconi anemia is a human genetic disorder with severe effects, including an increased risk of cancer and infertility. Research in plants helps us understand the disease in humans, showing how a key protein functions in the exchange of genetic material.
Conclusion Our results have demonstrated that there was no effect of antagonist administration on days <6 and ≥6 of COH on ART outcomes. However, taking cost-effectiveness into consideration, we suggest an antagonist administration on days <6 of COH since the necessary gonadotropin dose is lower.
ConclusionsMost adolescents and parents inaccurately reported infertility risk, and more poorly estimated risk. Research is needed to identify additional factors associated with accurate understanding of cancer‐related infertility risk. Providers should be supported with user‐friendly educational tools to promote awareness of infertility risk.
Condition: Invitro Fertilization Intervention: Drug: Gonadotropins Sponsor: Cairo University Not yet recruiting
Dr Channa Jayasena, a consultant in reproductive endocrinology at Imperial College London, said: ‘We know little about hormone altering chemicals but our exposure to them is a concern.'
In this study we initiated an investigation into the effects on lifespan and reproductive success of Torin1 supplied via the diet, in once-mated and continually mated D. melanogaster females, and on the lifespan of once-mated males. The main finding was that the addition of Torin1 to the diet activated autophagy and led to significant lifespan extension in both sexes. Elevated egg production was observed in females fed Torin1, but overall this did not result in higher overall fertility, owing to higher egg infertility in these females. Hence, there was no evidence for a trade-off between longevity and total fecundity, or b...
Conclusions Testicular metabolite concentrations, measured by proton spectroscopy at 3 T, may be valuable as noninvasive biomarkers of spermatogenesis.
Conditions: Recurrent Pregnancy Loss; Unexplained Infertility Interventions: Diagnostic Test: Uterine ERA and microbiome testing; Drug: Oral antibiotics and vaginal probiotics Sponsors: Stanford University; Instituto Valenciano de Infertilidad, IVI VALENCIA Recruiting
Conditions: Infertility, Female; Ovarian Stimulation; In Vitro Fertilisation Interventions: Drug: Pergoveris; Drug: Clomiphene Sponsor: Nova Clinic, Russia Recruiting