Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years.
This study aimed to find risk factors in HIV-infected patients with early decline renal function or less than 90 ml/min/1.73m(2). The study was retrospective conducted at Chonprathan Hospital, Thailand. The inclusion criteria were HIV-infected adult patients who were treated at the hospital's HIV clinic and whose eGFR levels at the first visit had been evaluated. Eligible patients were categorized by eGFR level at 90 ml/min/1.73(2). Multivariate logistic analysis was performed to evaluate the association of the eGFR of less than 90 ml/min/1.73(2). There were 301 HIV-infected patients included in the study. Of those, 89 patients (29.57%) had an eGFR of less than 90 ml/min/1.73(2). Age was the only significant factor associated with an eGFR of less than 90 ml/min/1.73(2) with an adjusted OR of 1.072 (95% confidence interval of 1.015, 1.132). Age of over 37 years predicted eGFR of less than 90 ml/min/1.73m(2) in HIV-infected patients with a sensitivity of 80.90% and specificity of 34.91%. Age is independently associated with eGFRs of less than 90 ml/min/1.73(2) in HIV-infected patients. Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years. PMID: 28890502 [PubMed - as supplied by publisher]
Around 850 million people currently are affected by different types of kidney disorders.1 Up to 1 in 10 adults worldwide has chronic kidney disease (CKD), which is invariably irreversible and mostly progressive. The global burden of CKD is increasing, and CKD is projected to become the fifth most common cause of years of life lost globally by 2040.2 If CKD remains uncontrolled and if the affected person survives the ravages of cardiovascular and other complications of the disease, CKD progresses to end-stage kidney disease, where life cannot be sustained without dialysis therapy or kidney transplantation.
Potassium channels are important to control membrane potential and drive epithelial transport processes. In this issue of Kidney International, Bignon et al. report the role of the Kir4.2 K+-channel, localized at the basolateral membrane of proximal tubules, in the reabsorption of bicarbonate and the modulation of renal ammoniagenesis. The findings have implications for our understanding of how the kidney reacts to hypokalemia, an acid load, and th e metabolic acidosis of patients with advanced stages of chronic kidney disease.
With increasing incidence and a prevalence of>10% among adults worldwide, chronic kidney disease (CKD) represents a major public health issue.1 CKD can lead to metabolic disorders and progress to end-stage kidney disease, and it increases the risk for cardiovascular disease and mortality. Our limited understanding of CKD pathophysiology and the mechanisms influencing kidney function in the healthy range represents a major barrier to the development of treatments targeting the causes rather than the symptoms of CKD.
[Vanguard] In recent times, the number of people coming down with kidney disease has been on the increase and many reasons have been adduced to explain the rise in number of cases. Chief among the reasons are the rise in cases of diabetes and high blood pressure; which experts say, increase the risk of chronic kidney disease. However, one disease which experts say could lead to kidney failure, respiratory disease, meningitis, liver failure and even death if left untreated, is little known leptospirosis, considered th
(World Scientific) A search using medical data bases reveals that hundreds of meta-analysis papers conducted with tens of millions of people worldwide have confirmed clinically the efficacies of 30 antioxidant-rich foods to prevent or treat chronic diseases, including hypertension, diabetes, cardiovascular disease, cognitive impairment, chronic kidney disease, cancer, and more. Professor Monte Lai, former professor of biophysics at the Medical College of Wisconsin talks about this and more in his new book 'The Food Cure.'
ConclusionHigh salt downregulated Nrf2 mainly via a sodium-dependent manner in kidney collecting duct cells, which might contribute to the excessive renal oxidative stress and CKD progression.
Those who consume up to 20 drinks per week are less likely to develop chronic kidney disease than never drinkers, but authors warn"potential benefits" of alcohol must be weighed against"harms."Medscape Medical News
The agreement is for Desidustat, a novel oral HIF-PH inhibitor for the treatment of anemia in patients with Chronic Kidney Disease (CKD) not-on-dialysis and for the treatment of anemia CKD patients on dialysis in Greater China, Zydus said in a statement. "Under the license agreement, CMS will pay Zydus an initial upfront payment," it added.
ConclusionsBoth models described imipenem popPK well; the parameter estimates were comparable and the included covariate was identical. However, estimated BSV was higher in the nonparametric model. This may have consequences for estimated exposure during dosing simulations and should be further investigated in simulation studies.