An alarmingly high proportion of anti-retroviral drugs resistant HIV-1 infection among high risk groups in central Vietnam: A sub-study of the national sentinel survey.

An alarmingly high proportion of anti-retroviral drugs resistant HIV-1 infection among high risk groups in central Vietnam: A sub-study of the national sentinel survey. Jpn J Infect Dis. 2017 Sep 11;: Authors: Do HT, Nguyen DT, Nguyen LAT, Do DH, Le HX, Trinh XMT, Ton HVN, Sawada I, Kitamura N, Le NM, Yoshihara K, Phan THT, Bui CT, Ariyoshi K, Yoshida LM Abstract We investigated the prevalence of HIV drug resistance among high risk groups such as injecting drug user (IDU), female sex worker (FSW) and men having sex with men (MSM) in central Vietnam. We used HIV positive samples from 2012-2013 sentinel surveillance surveys. Study subjects were screened for HIV infection by standardized screening assays and the positive samples were further tested for HIV viral load and drug resistant mutations by in-house assays. Drug resistant mutations (DRMs) were determined using the Stanford University online sequence analysis tool. Their risk behaviors were also investigated. During the study period, 6,016 subjects were screened and 97 were positive (IDU: N=63, 3%, FSW: N=24, 0.8% and MSM: N=10, 1%). Ninety-two samples (45 from 2012 and 47 from 2013) were available for further testing. HIV viral load was detected in 56 (60.9%) samples and drug resistant genotyping was successfully performed in 40 (71.4%) samples. All were CRF01_AE, except for one (2.5%) IDU with subtype B. Thirteen individuals (32.5%) were carrying HIV virus with at least one HIV...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research