Update on the structure of oxazolidinone analogues and comparing their in vitro and intracellular efficacy with linezolid against clinically relevant bacterial species.

Update on the structure of oxazolidinone analogues and comparing their in vitro and intracellular efficacy with linezolid against clinically relevant bacterial species. Jpn J Infect Dis. 2017 Sep 11;: Authors: Tang Q, Zhao Y, Xu B, Gong P, Wang D Abstract  Oxazolidinones comprise a novel class of antimicrobials as inhibitors of bacterial ribosomal protein synthesis. In the present study, we identified 15 novel oxazolidinone analogues with potent antituberculosis activities. Compounds sy124 and sy125 displayed the best antituberculosis activity in vitro, against various clinically relevant bacterial species, including most Gram positive bacteria, Mycobacterium and Helicobacter pylori, which are better than that of the linezolid. Cell based assay indicated that these compounds showed strong ability to kill the intracellular pathogens. Our results indicate that these identified compounds could be further developed as novel antimicrobial agents. PMID: 28890512 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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Source: Methods in Microbiology - Category: Microbiology Source Type: research
Source: Gut Microbes - Category: Microbiology Authors: Source Type: research
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Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Condition:   Helicobacter Pylori Infection Intervention:   Diagnostic Test: rapid urease test Sponsor:   King Chulalongkorn Memorial Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Zhang L, Lan Y, Wang Q, Zhang Y, Si X Abstract Aim: To evaluate the eradication rate, safety, and compliance of minocycline-containing bismuth quadruple regimens in patients with an untreated Helicobacter pylori (H. pylori) infection. Methods: A total of 360 patients with an untreated H. pylori infection were enrolled in this study between June 2017 and October 2018. Patients were randomly divided into a minocycline/amoxicillin (RMAB) group, a minocycline/metronidazole (RMMB) group, or an amoxicillin/clarithromycin (RACB) group, and all groups received a combined treatment approach with rabeprazole and...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
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Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: LETTER TO THE EDITOR Source Type: research
Abstract Functional dyspepsia is defined as at least one month of epigastric discomfort without evidence of organic disease found during an upper endoscopy, and it accounts for 70% of dyspepsia. Symptoms of functional dyspepsia include postprandial fullness, early satiety, and epigastric pain or burning. Functional dyspepsia is a diagnosis of exclusion; therefore, evaluation for a more serious disease such as an upper gastrointestinal malignancy is warranted. Individual alarm symptoms do not correlate with malignancy for patients younger than 60 years, and endoscopy is not necessarily warranted but should be consi...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Authors: Yang W, Yang X Abstract Background: Helicobacter pylori infection is a common chronic infection worldwide. At the same time, the incidence of colorectal adenomatous polyps is also at high levels. In order to assess the relationship between Helicobacter pylori infection and the occurrence of colorectal adenomatous polyps, we observed 166 patients who had undergone an electronic colonoscopy and 13C urea breath test in the outpatient clinic. Method: A total of 166 (87 males and 79 females, aged 53.85 ± 9.18 years) patients who had colonoscopy examination and 13C urea breath test were divided into a...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
This study investigated the molecular targets of the component herbs of QLSP in preventing precancerous lesions based on network pharmacology. Network pharmacology analysis revealed that the 6 herbs regulated multiple CAG-related genes, among which the most important were cancer-related pathway (apoptosis, p53, and VEGF) and epithelial cell signaling in Helicobacter pylori infection. Further animal experiments showed that the expression of survivin and p53 in precancerous lesions of CAG rats was significantly increased which was suppressed by QLSP. Moreover, telomerase activity was inhibited in precancerous lesions of CAG ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
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