Microrna-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice.

• MiR-22 knock-out mice have a blunted interferon response to viral infection.• MiR-22 exerts reciprocal effects on megakaryocyte and erythrocyte maintenance during infection.• MiR-22 is expressed in Stage II erythroid progenitors to regulate the pace of differentiation.

Source: Experimental Hematology - September 11, 2017 Category: Hematology Authors: Claudine S. Kadmon, Cameron T. Landers, Haiyan S. Li, Stephanie S. Watowich, Antony Rodriguez, Katherine Y. King Source Type: research