Changes in the level of Long Non-Coding RNA Gomafu gene expression in schizophrenia patients before and after antipsychotic medication

Schizophrenia (SCZ) is a serve and heritable mental disorder with a prevalence of approximately 1% worldwide population, characterized by delusions, hallucinations, cognitive impairment and abnormal social behavior. Despite major progress have made in recent decades, the underlying pathogenesis of SCZ are still unclear.
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research

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Authors: Chen R, Liou TH, Miao NF, Chang KH, Yen CF, Liao HF, Chi WC, Chou KR Abstract Little is known about the changes of people with schizophrenia disability in Taiwan who receive routine treatments under the current mental healthcare system. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) was used to assess and track changes in the degree of disability in people with schizophrenia before and after 4 years of follow-up. Data on 4497 people with schizophrenia were acquired from the Taiwan Data Bank of Persons with Disability. The WHODAS 2.0 was used for disability assessment, and the...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
CONCLUSIONS: There is evidence of declining continuity of care in this 11-year study of people with schizophrenia, and of an independent effect of this on worse clinical outcomes. We suggest that this is related to reorganisation of services.Declaration of interestNone. PMID: 31012407 [PubMed - in process]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Conclusions: Prefrontal gyrification is reduced in children with ADHD who also carry the DRD4 7R allele, and it relates to critical functional skills in the executive domain in carriers of the risk allele. More broadly, these effects highlight the importance of considering precise neurodevelopmental mechanisms through which risk alleles influence cortical neurogenesis and migration.IntroductionAttention deficit/hyperactivity disorder (ADHD) is a heterogeneous neuropsychiatric disorder characterized by developmentally inappropriate symptoms of inattention, impulsivity, and hyperactivity. The disorder is thought to affect ar...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitiv...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This study is … the first, to our knowledge, to describe the correlates of subsequent injurious violence among patients being treated for schizophrenia in which the independent variables include recent violence toward others,” wrote Alec Buchanan, Ph.D., M.D, of Yale University School of Medi cine and colleagues.The analysis included 1,435 participants in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study. Researchers assessed participants ’ clinical condition and violent behavior at baseline and every six months for the duration of the 18-month study.Violent behavior was self-...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance Alec Buchanan CATIE medication adherence schizophrenia violence Yale Source Type: research
Abstract PROBLEM IDENTIFICATION: The impact of mental health disorders (MHDs) and substance use disorders (SUDs) on healthcare utilization (HCU) in patients with cancer is an understudied phenomenon. LITERATURE SEARCH: A literature search of studies published prior to January 2018 that examined HCU in patients with preexisting MHDs or SUDs diagnosed with cancer was conducted. DATA EVALUATION: The research team evaluated 22 studies for scientific rigor and examined significant trends in HCU, as well as types of the MHD, SUD, and cancer studied. SYNTHESIS: The heterogeneity of HCU outcome measures, MH...
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
This study was carried out in accordance with the recommendations of the National Animal Care and Use Committee of the University of Buenos Aires (CICUAL). The protocol was approved by the CICUAL. Mice were kept under a 12-h light/dark cycle, with controlled temperature (23 ± 2°C) and humidity (40–60%) and had ad libitum access to food and water. To produce hTDP-43 transgenic lines, as described previously (Igaz et al., 2011), pronucleus of fertilized eggs from C57BL/6J × C3HeJ F1 matings were injected with a vector containing hTDP-43-WT cDNA. Monogenic tetO-TDP-WT12 mice wer...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study serves as an example of how population genomic analyses can yield novel insights into human behavior. Introduction Mate choice is a fundamental dimension of human behavior with important implications for population genetic structure and evolution (Vandenburg, 1972; Buss, 1985; Robinson et al., 2017). It is widely known that humans choose to mate assortatively rather than randomly. That is to say that humans, for the most part, tend to choose mates that are more similar to themselves than can be expected by chance. Historically, assortative mating was based largely on geography, whereby partners were chos...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study employed a double-blind, randomized, crossover design, in which 24 healthy right-handed participants conducted MEG recordings during a 3-back task after administration of 2 mA tDCS or sham stimulation as a placebo. Our results showed that the effect of tDCS did not appear in the behavioral indices—WM accuracy (d′) or reaction time (RT). From the results of the time-frequency analysis, significant event-related synchronization (ERS) in the high-gamma band (82–84 Hz) of the left DLPFC was found under the tDCS condition; however, ERS was not correlated with WM capacity. Furthermore, we calculated ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function, Published online: 24 April 2019; doi:10.1038/s41380-019-0423-3iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function
Source: Molecular Psychiatry - Category: Psychiatry Authors: Source Type: research
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