Morphine and the blood-brain barrier: diffusion, uptake, or efflux?
This study aimed to evaluate the effect of poly(dimethylsiloxane) on the mechanical properties of chitosan-alginate (CA) polyelectrolyte complexes (PECs) with potential application as wound dressing biomaterials. For that purpose, different amounts of poly(dimethylsiloxane) were incorporated during the formulation of the PECs. Results showed that the highest tensile strength was observed when using 0.1 g of poly(dimethylsiloxane) per gram of PEC (CAS10). This formulation was also non-hemolytic, capable of inducing thrombus formation to potentially reduce bleeding, and additionally presented high stability when exposed to...
Authors: Szarpak L Abstract INTRODUCTION: According to the American Society of Anesthesiologists, the incidence of difficult intubation in the operating room is 1.2-3.8%; however, in emergency conditions, this rate is higher and reaches even 5.3%. Successful emergency airway management is an essential component of the modern practice of medicine. Areas covered: The aim of the study is to review the literature regarding different devices used to perform endotracheal intubation (Macintosh, Miller, and McCoy laryngoscopes; ETView, GlideScope, TruView, Airtraq, McGrath MAC, Pentax AWS, Trachlight, Shikani, and Bullard)...
Conclusions: This study demonstrated significant in vivo supraspinatus tenotoxicity following a single injection of combination local anesthetic/ corticosteroid when compared to saline controls. Level of Evidence: Level II. PMID: 30104932 [PubMed - in process]
Conclusion: This study suggests that FSB may be a more effective pain management technique for reducing the total IV morphine equivalent dose, maximum NRS pain scores, number of PACU postoperative opioid doses, and PACU LOS following ACL reconstruction in the pediatric population.Level of Evidence: III. PMID: 30104931 [PubMed - in process]
Some significant benefits observed in quality of life domains for patients with newly diagnosed HNC
Expert panel recommends five action steps for treating opioid abuse and its intersecting epidemics
Authors: Davies GAL, Maxwell C, McLeod L Abstract OBJECTIVE: To review the evidence and provide recommendations for the counselling and management of obese parturients. OUTCOMES: Outcomes evaluated include the impact of maternal obesity on the provision of antenatal and intrapartum care, maternal morbidity and mortality, and perinatal morbidity and mortality. EVIDENCE: Literature was retrieved through searches of Statistics Canada, Medline, and The Cochrane Library on the impact of obesity in pregnancy on antepartum and intrapartum care, maternal morbidity and mortality, obstetrical anaesthesia, and perinat...
This study tested and compared the heating capabilities of three small fluid warming systems. Are they as effective as full-size units at maintaining stable heating?BMC Anesthesiology
Conditions: Hand Surgery; Quality of Recovery; Hand Injuries; Hand Fracture; Hand Tendon Injury; Anesthesia, Local Intervention: Procedure: Local anesthesia with minimal sedation Sponsor: McGill University Health Center Not yet recruiting
Condition: Anesthesia Intubation Complication Intervention: Drug: Ketamine Sponsor: University Hospital, Mahdia Recruiting