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Morphine and the blood-brain barrier: diffusion, uptake, or efflux?

Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research

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Authors: Lee AJ, Yabes JG, Hale N, Hrebinko RL, Gingrich JR, Maranchie JK, Fam MM, Turner I I RM, Davies BJ, Ben-David B, Jacobs BL Abstract INTRODUCTION: Multimodal analgesia is an effective way to control pain and limit opioid use after surgery. The quadratus lumborum block and paravertebral block are two regional anesthesia techniques that leverage multimodal analgesia to improve postoperative pain control. We sought to compare the efficacy of these blocks for pain management following radical cystectomy. MATERIALS AND METHODS: We performed a retrospective review of radical cystectomy patients who received b...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
It is not uncommon to see air in the ventricular system and the subarachnoid space after resection of vestibular schwannoma in the semisitting position. It resolves spontaneously within 1 –2 weeks. Sometimes, it causes headache. In severe cases of air collection (tension pneumocephalus), the patients show delayed inadequate recovery from the anesthesia. In these cases, after confirmation of the presence of the tension pneumocephalus with postoperative computed tomography, we usual ly release the entrapped air, especially if it affects the conscious level of the patient by a burr hole.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Letter to the Editor Source Type: research
14 –18 May 2018, Boston, United States
Source: Scientific and Medical Events on Global Events List - Category: Science Source Type: events
Just heard an attending talking about how if you really love anesthesia, cardio and CCM the way to go would be a combined IM/Anesthesia residency (or even just anesthesia) then do a CC Fellow along with a cardiac anesthesia Fellowship. You would be a master of physio in regards to CC (due to the combined residency with IM) along with the procedures of Anesthesia. With the cardiac fellowship you can do nearly any anesthesia case and then man the CICUor even just ICU. Biggest drawback is... IM/Anes --> Cardiac --> CC?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
The objective of this study was to develop a reproducible animal model for SADI-S. We used three techniques for duodenal exclusion and duodenoileal anastomosis: (a) surgical clip and side-to-side anastomosis, (b) ligation and side-to-side anastomosis and (c) sectioning the duodenum, closing the duodenal stump and end-to-side anastomosis. We recorded the surgical technique and complications for each method. Twenty-five of 31 rats survived to the end of the study period. One death occurred from accidental anaesthesia overdose and the others from anastomosis leak. Four duodenal exclusions had repermeabilised at necropsy. Our ...
Source: Obesity Surgery - Category: Surgery Source Type: research
Conclusions Our work demonstrates that bupivacaine has direct anti-cancer activities with the dominant inhibitory effects on gastric cancer migration rather than growth and survival. Our findings also guide a proper understanding and provide underlying mechanisms on how local aesthesis could affect cancer patients.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Xiangbiao Yan, Yu Li, Xuechang Han, Xu Dong, Yajie Zhang, Qunzhi Xing As a new generation of amide-type local anesthetics (LAs), ropivacaine has been widely used for pain management in clinical settings. Increasing evidence has shown that administration of ropivacaine causes cytotoxic effects and apoptosis. However, the underlying molecular mechanisms still need to be elucidated. In the current study, our results indicated that ropivacaine treatment caused a significant induction of heme oxygenase-1 (HO-1) at both the mRNA and prot...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
At ages 8 to 12 and 15 to 20, all three groups were similar in terms of IQ, memory and several other measures of brain function, according to the study authors.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Conclusions: Levosimendan therapy proved safe in the study group. The nature of the study and the small sample size preclude the formulation of detailed conclusions. PMID: 29681959 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
Authors: Walaszczyk M, Wiench R, Copik M, Karpe J, Łowicka M, Pióro A, Knapik P, Misiołek H Abstract Introduction: Pectus excavatum repair (Nuss procedure) is a painful procedure requiring effective postoperative analgesia. Aim: To establish whether thoracic epidural analgesia with ropivacaine is non-inferior to epidural analgesia with bupivacaine following the Nuss procedure in children. Material and methods: The prospective, randomized, controlled, single blind study included 81 children. Computer-generated random numbers were used to allocate treatment. All children received general anesthesia. Intra...
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
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