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'Somebody needs to step up': Drug exec starts nonprofit to hike access, lower costs

From Ebola to diabetes, some drugs aren't making it to patients because of cost. Jim Wilkins and his nonprofit, Fair Access Medicines, want to change that.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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Publication date: Available online 7 May 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Sandip Patel, Bethan S. Kilpatrick Two-pore channels (TPCs) are Ca2+-permeable endo-lysosomal ion channels subject to multi-modal regulation. They mediate their physiological effects through releasing Ca2+ from acidic organelles in response to cues such as the second messenger, NAADP. Here, we review emerging evidence linking TPCs to disease. We discuss how perturbing both local and global Ca2+ changes mediated by TPCs through chemical and/or molecular manipulations can induce or reverse disease ph...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Abstract Two-pore channels (TPCs) are Ca2+-permeable endo-lysosomal ion channels subject to multi-modal regulation. They mediate their physiological effects through releasing Ca2+ from acidic organelles in response to cues such as the second messenger, NAADP. Here, we review emerging evidence linking TPCs to disease. We discuss how perturbing both local and global Ca2+ changes mediated by TPCs through chemical and/or molecular manipulations can induce or reverse disease phenotypes. We cover evidence from models of Parkinson's disease, non-alcoholic fatty liver disease, Ebola infection, cancer, cardiac dysfunction ...
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Tags: Biochim Biophys Acta Source Type: research
Humanities and social sciences have had many positive influences on health experiences, care, and expenditure. These include on self-management for diabetes, provision of psychological therapy, handwashing, hospital checklists, the Scottish Government's stroke guidelines, England's tobacco control strategy, the response to the Ebola outbreak in west Africa and Zika virus in Brazil, and many more.1 Researchers have shown time and time again the political, practical, economic, and civic value of education and research in disciplines like anthropology, history, and philosophy.
Source: LANCET - Category: General Medicine Authors: Tags: Comment Source Type: research
NIH accomplishments in the prevention, diagnosis, and treatment of human disease. These include progress on two Ebola vaccines, a bionic pancreas to treat type 1 diabetes, and a genetic test that improves blood thinner dosing.
Source: NIH Research Matters from the National Institutes of Health (NIH) - Category: Consumer Health News Source Type: news
Have you ever thought that it would be possible to monitor drug overdoses, Zika cases or the spread of the flu in real time? Have you ever imagined that satellites wouldbe able to tell how and where a malaria epidemic will happen months before the actual outbreak? It is mind-blowing how, in the last years, digital maps developed to a level where they serve as effective tools for evaluating, monitoring and even predicting health events. That’s why I decided to give a comprehensive overview of digital maps in healthcare. John Snow, cholera and the revolution of maps in healthcare Before Game of Thrones monopolized Joh...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Healthcare Design Mobile Health digital health digital technology epidemics epidemiology gc4 Innovation interactive maps Source Type: blogs
[The Conversation Africa] When it comes to killer diseases in Africa many people think of infectious diseases like tuberculosis, malaria, or even Ebola. But the reality is that diseases like cancer, diabetes and heart disease - known as non-communicable diseases (NCDs) - are a major threat.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Tristate Heart and Vascular Centre in Nigeria. Credit: Tristate Heart and Vascular CentreBy Pavithra Rao, Africa Renewal*NEW YORK, Sep 28 2017 (IPS)In the 2017 World Happiness Report by Gallup, African countries score poorly. Of the 150 countries on the list, the Central African Republic, Tanzania and Burundi rank as the unhappiest countries in the world. Some of the factors driving unhappiness are the poor state of the continent’s health care systems, the persistence of HIV/AIDS, malaria and tuberculosis, and the growth of lifestyle diseases such as hypertension, heart disease and diabetes.Few African countries make...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Featured Global Headlines Health TerraViva United Nations Source Type: news
Conclusions: These new resources offer substantial advances to classical toxicity testing paradigms by including genetically sensitive individuals that may inform toxicity risks for sensitive subpopulations. Both in vivo and complementary in vitro resources provide platforms with which to reduce uncertainty by providing population-level data around biological variability. https://doi.org/10.1289/EHP1274 Received: 25 October 2016 Revised: 19 April 2017 Accepted: 27 April 2017 Published: 15 August 2017 Address correspondence to K.A. McAllister, Program Administrator, Genes, Environment, and Health Branch, Division of E...
Source: EHP Research - Category: Environmental Health Authors: Tags: Review Source Type: research
The drug sends a message to a caregiver after the patient swallowed it. The doctor prescribes virtual reality treatments for migraines. Do you think it is science fiction? You are mistaken. Just let me familiarize you with the top 10 trends shaping the future of pharma. I gave a speech recently to an audience of professionals working in healthcare regulation for the invitation of the Consumer Healthcare Products Association in Washington. After the keynote, a guy raised his hand and asked me the following: how can a regulatory agency keep up with the speed of new technologies in pharma? I get a lot of questions like this o...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Future of Pharma 3d printing artificial intelligence augmented reality digital health gc4 Innovation nanotechnology Personalized medicine pharmacies pharmacogenetics pharmacology virtual reality VR Source Type: blogs
The new BMJ has a lot to say about air pollution, starting withthis editorial. Everything they say about the UK applies to the US, if not more so. Nowadays the most important source of exposure to polluted air in the industrialized countries is motor vehicle exhaust. Two components, ultrafine particles and oxides of nitrogen, cause the most damage to human health. Ultrafine particles are less than 2.5 microns in diameter -- microscopic, invisible, and odorless. They are in highest concentration near highways, which also happens to be where the nearby residents are likely to be low income people. A favorite place to site lo...
Source: Stayin' Alive - Category: American Health Source Type: blogs
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