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Being 'fat but fit' is actually impossible, new study says

A study from the University of Birmingham has found that even obese individuals who do not have diabetes or hypertension have an increased risk of developing fatal diseases.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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AbstractPurpose of ReviewThis review summarizes the current knowledge on the relationship of physical activity, exercise, and cardiorespiratory fitness (CRF) with cardiovascular autonomic neuropathy (CAN) based on epidemiological, clinical, and interventional studies.Recent FindingsThe prevalence of CAN increases with age and duration of diabetes. Further risk factors for CAN comprise poor glycemic control, dyslipidemia, abdominal obesity, hypertension, and the presence of diabetic complications. CAN has been also linked to reduced CRF. We recently showed that CRF parameters (e.g., maximal oxidative capacity or oxidative c...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
This study used an in vitro approach to assess the potential of four extracts of Siegesbeckia orientalis linne on key enzymes relevant to metabolic syndrome. In this research, S. orientailis was firstly extracted by ethanol. The ethanol extract (SE) was then partitioned sequentially with hexane, ethyl acetate and methanol, and these extracts were named SE-Hex, SE-EA and SE-MeOH, respectively. The experimental results showed that SE-EA had the highest total phenolic content (TPC, 76.9 ± 1.8 mg/g) and the total flavonoids content (TFC, 5.3 ± 0.3 mg/g). This extract exhibited the most significant antioxidant act...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
As a primary care doctor, I see a lot of women dealing with the inconvenience, discomfort, and embarrassment of urinary incontinence (unintended leaking of urine). Some are comfortable bringing this up right away. Others suffer needlessly because they feel too shy or awkward to mention it. The truth is, an estimated 45% of women experience some form of urinary incontinence at some point in their lives. That’s almost half of all women! It’s a very big deal. Urinary incontinence can negatively affect physical and emotional well-being. For example, women may avoid going out because they’re worried about havi...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Kidney and urinary tract Women's Health Source Type: blogs
CONCLUSION: We found a marginal association between BMI and an increased risk of developing AKI in adult patients after having noncardiac laparoscopic surgery. The BMI effect became insignificant when potential mediator variables were considered. The association of BMI and AKI after noncardiac laparoscopic surgery is likely mediated through components of the metabolic syndrome. PMID: 29026353 [PubMed]
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
Obstructive sleep apnea (OSA) is a highly prevalent condition that is associated with excessive daytime sleepiness, reduced quality of life, hypertension, and increased cardiovascular risk.[1] Patients with type 2 diabetes are at particularly high risk for OSA. The Sleep Heart Health Study, a community-based cohort study, observed a 58% prevalence of OSA among participants with type 2 diabetes. Similarly, in a subset of overweight and obese diabetics participating in the LookAHEAD trial, the prevalence of OSA was over 86%.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Conclusion: The established real‐time PCR assay is a sensitive, specific, and repeatable method for quantitatively detecting crAssphage, and thus is a very useful tool for investigating the molecular epidemiology, dynamics, and pathogenicity of crAssphage in human diseases. This article is protected by copyright. All rights reserved
Source: Journal of Medical Virology - Category: Virology Authors: Tags: Research Article Source Type: research
Background: Stressors associated with military service and reintegration may impact psychologic well-being and behaviors that result in increased incidence rates for cardiovascular (CV) risk factors. Objective: Using electronic health record data from the Veterans Health Administration we sought to measure the incidence of newly diagnosed CV risk factors and how these incident risks were moderated by race and mental health conditions. Design: A cohort study including Veterans whose end of last deployment was between October 1, 2001 and July 31, 2014. Subjects: A total of 267,305 Operations Iraqi Freedom, Enduring Freedo...
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
AbstractHeart failure and atrial fibrillation are common and responsible for significant mortality of patients. Both share the same risk factors like hypertension, ischemic heart disease, diabetes, obesity, arteriosclerosis, and age. A variety of microscopic and macroscopic changes favor the genesis of atrial fibrillation in patients with preexisting heart failure, altered subcellular Ca2+ homeostasis leading to increased cellular automaticity as well as concomitant fibrosis that are induced by pressure/volume overload and altered neurohumoral states. Atrial fibrillation itself promotes clinical deterioration of patients w...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Conclusions Women with prolonged labour do not appear to be at a higher short-term risk of cardiac outcomes. Teaser We assessed the risk of heart failure, cardiomyopathy or dysrhythmia in women with a history of prolonged labour. We conducted a population-based cohort study in the entire province of Ontario, including all singleton livebirths at 24 to 41 weeks’ gestation, between 1992 and 2016. Women with prolonged labour dif not appear to be at a higher future risk of the heart failure, cardiomyopathy or dysrhythmia.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Authors: Mahmoud AM Abstract Cardiomyopathy is a serious complication of diabetes mellitus and occurs independently of coronary artery disease or hypertension. It manifests as systolic/diastolic dysfunction and hypertrophy of the left ventricle and can lead to heart failure. Hyperglycemia can trigger a series of maladaptive stimuli and result in cardiac hypertrophy, fibrosis and reduced performance and contractility. The pathogenesis of diabetic cardiomyopathy is a multifactorial process that includes metabolic derangements such as increased oxidative stress, and altered non-oxidative glucose pathways and lipid met...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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