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France to prosecute its drug regulator and Servier in scandal over diabetes drug

Source: BMJ News - Category: General Medicine Source Type: research

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This study aimed to evaluate the predictors of delayed surgical intervention in ASDH patients who are initially managed conservatively. Methods: From January 2007 to December 2015, 842 patients diagnosed with ASDH were treated at our institution. Among them, 158 patients with convexity ASDH were initially treated conservatively. Patients were divided into a delayed surgery group and a conservative group. Demographic characteristics, past medication and medical histories, and radiological and laboratory data were collected by retrospective chart review. Independent risk factors were identified with univariate and multiv...
Source: Journal of Korean Neurosurgical Society - Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
Intestinal regulatory T (Treg) cells are critical to maintaining immune tolerance to dietary antigens and gut microbiota. This paper reviews several papers on this topic that were recently published by Japanese researchers. Specifically, Prof. K. Honda and his group have found that commensal microbiota capable of metabolizing butyrate induces the differentiation of colonic Treg cells. In a separate work, Prof. Y. Yokoyama and his group used a novel, culture-independent analytical method (the Yakult Intestinal Flora-Scan) for detection of bacteria in the bloodstream. Their work revealed that bacteremia in invasive surgery p...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
Being exposed to workplace bullying and violence may increase the risk of developing type 2 diabetes, for both men and women, according to researchers from Scandinavia.
Source: Nursing Times - Category: Nursing Source Type: news
DIABETIC MACULAR EDEMA: TRADITIONAL AND NOVEL TREATMENT. Acta Clin Croat. 2017 03;56(1):124-32 Authors: Tomić M, Vrabec R, Poljičanin T, Ljubić S, Duvnjak L Abstract Diabetes is one of the leading public health problems worldwide. Diabetic macular edema (DME) is the main cause of vision loss in patients with diabetes. Ideal metabolic control of diabetes is the primary goal of treatment and the basic way of preventing and stopping the progression of DME. Although laser photocoagulation has been the standard treatment of DME for nearly three decades, superior outcomes can be achieved with novel, intra...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
DIABETIC MACULAR EDEMA: TRADITIONAL AND NOVEL TREATMENT. Acta Clin Croat. 2017 03;56(1):124-32 Authors: Tomić M, Vrabec R, Poljičanin T, Ljubić S, Duvnjak L Abstract Diabetes is one of the leading public health problems worldwide. Diabetic macular edema (DME) is the main cause of vision loss in patients with diabetes. Ideal metabolic control of diabetes is the primary goal of treatment and the basic way of preventing and stopping the progression of DME. Although laser photocoagulation has been the standard treatment of DME for nearly three decades, superior outcomes can be achieved with novel, intra...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
PITUITARY ABSCESS WITH UNUSUAL CLINICAL COURSE. Acta Clin Croat. 2016 12;55(4):650-4 Authors: Stojanoska MM, Kozić D, Bjelan M, Vuleković P, Vučković N, Vuković B, Zavišić BK Abstract The aim is to present unusual clinical course and magnetic resonance imaging (MRI) features of pituitary abscess. A 59-year-old man presented with fever, polyuria, polydipsia and marked weight loss within the last two months. Basic endocrinology tests revealed the presence of anterior pituitary dysfunction, associated with central diabetes insipidus and increased levels of inflammatory markers. The presence o...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
ConclusionsWhen evaluating RCTs which included criteria for pharmacologic GDM therapy dose adjustment, the most common criteria for diagnosis was the two step test, and the most common used therapies were insulin and metformin. Regarding glucose monitoring, the most common frequency was four times per day, fasting and 2 hours after each main meal, using as target glucose values 95mg/dL and 120mg/dL, respectively. Importantly, we found six different criteria for pharmacologic GDM therapy dose adjustment, with the majority using very tight criteria of either 1 or 2 values per week higher than the target values, of which two ...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Systematic review Source Type: research
CONCLUSION: A method based on multiplex PCR and LDR was established for simultaneous detection of four SNP loci of T2DM susceptibility genes. PMID: 29128291 [PubMed - as supplied by publisher]
Source: Analytical Biochemistry - Category: Biochemistry Authors: Tags: Anal Biochem Source Type: research
Publication date: 1 January 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 161 Author(s): Eva Bystrenova, Zuzana Bednarikova, Marianna Barbalinardo, Francesco Valle, Zuzana Gazova, Fabio Biscarini Peptide aggregation into oligomers and fibrillar architectures is a hallmark of severe neurodegenerative pathologies, diabetes mellitus or systemic amyloidoses. The polymorphism of amyloid forms and their distribution are both effectors that potentially modulate the disease, thus it is important to understand the molecular basis of protein amyloid disorders through the interaction of the different amyloid forms with ...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
This study also suggests that inhibition of MXL-3 may serve as a potential target for the treatment of chronic metabolic diseases, including obesity, type 2 diabetes, and cardiovascular disease.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
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