Toll-like Receptor 4 and Hepatitis B Infection: Molecular Mechanisms and Pathogenesis

Viral Immunology , Vol. 0, No. 0.
Source: Viral Immunology - Category: Allergy & Immunology Tags: article Source Type: research

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Authors: Liu Y, Shi C, Fan J, Wang B, Li G Abstract Introduction: Multiple studies have revealed a strong relationship between the development of nephropathy and hepatitis B virus (HBV) infection. The underlying pathogenesis of hepatitis B-related glomerulonephritis (HBV-GN) involves immune complexes, which can be isolated from kidney tissues. Clearance of HBV antigenemia improves renal impairment and proteinuria in HBV-GN patients.Areas covered: In this review, we present our current understanding of the epidemiology, pathogenesis, pathology, diagnosis, and treatment of HBV-GN. We discuss the advantages and disadv...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Abstract Ultramarine blue particles as a novel visible label has been used to develop immunochromatographic assay (ICA). The ultramarine blue particles, as a sodalite mineral with formula: (Na,Ca)8[(S,Cl,SO4,OH)2(Al6Si6O24)], can generate a blue visible signal were used as a label for ICA. Ultramarine blue particles were applied to a sandwich immunoassay to detect hepatitis B virus surface antigen (HBsAg). Ultramarine blue particles were separated from ultramarine blue industrial product by centrifugation. The polyacrylic acid (PAA) was used to modify the carboxyl group on the surface of ultramarine blue particles...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract From December 2006 to December 2016, 1093 human immunodeficiency virus (HIV) individuals
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research
Publication date: Available online 17 January 2020Source: European Journal of RadiologyAuthor(s): Hong Wei, Han-Yu Jiang, Mou Li, Tong Zhang, Bin SongAbstractPurposeTo determine the diagnostic performance and cutoff value of two-dimensional shear wave elastography (2D SWE) for detecting significant liver fibrosis in patients with chronic hepatitis B (CHB).MethodsA systematic literature search of the PubMed, EMBASE, Cochrane Library databases and Web of Science was conducted. Bivariate modelling and summary receiver-operating-characteristic (ROC) modelling were constructed to summarize the diagnostic performance of 2D SWE. ...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Publication date: Available online 17 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Seung In Seo, Hyoung Su Kim, Bo Kyung Yang, Jin Gu Kang, Woon Geon Shin, Jin Heon Lee, Hak Yang Kim, Myoung Kuk JangSummaryBackground and aimsThe risk factors for hepatocellular carcinoma (HCC) in immune inactive chronic hepatitis B (CHB) have not been clarified. The aim of this study was to investigate the predictive factors for HCC inimmune inactive CHB.MethodsA total of 337 patients in immune inactive CHB were consecutively enrolled in Kangdong Sacred Heart Hospital from 1995 to 2017. Univariate an...
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
More than 2 billion people are infected with hepatitis B virus (HBV) worldwide. The prevalence of chronic HBV infection is high (6.2%) in the Western Pacific and African regions [1]. Many researchers are aware of the risk of HBV reactivation in previously infected patients during immunosuppressive therapies such as chemotherapy, rituximab therapy and glucocorticoids [2,3]. The prevalence of hepatitis B core antibody (HBcAb) ranges from 5% in Western countries to>50% in Far Eastern countries [4 –6].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Condition:   Hepatocellular Carcinoma Interventions:   Drug: P1101 (Ropeginterferon alfa-2b);   Drug: Nivolumab Sponsors:   National Taiwan University Hospital;   PharmaEssentia Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsReceiving the birth dose is positively associated with up-to-date status later in childhood, highlighting the importance of starting vaccination early. The association is insensitive to confounding by factors observed in National Immunization Survey-Child, but investigation of unobserved factors such as vaccine hesitancy could provide critical information to guide intervention strategy.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Authors: Suoh M, Tamori A, Amano-Teranishi Y, Nakai T, Enomoto M, Kawasaki Y, Kioka K, Kawada N Abstract The appropriate management of hepatitis B virus (HBV) infection during pregnancy has not been established in Japan. We herein report five HBV-infected pregnant Japanese women who received tenofovir disoproxil fumarate (TDF). Two of them had been born after the introduction of nationwide immunoprophylaxis and were vertically infected with HBV, highlighting the need to address mother-to-child transmission further. In both entecavir-experienced and nucleoside/nucleotide analog-naïve mothers, TDF suppressed HBV...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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