Nurses' regular use of disinfectants is associated with developing COPD
(European Lung Foundation) Regular use of disinfectants is linked to a higher risk of developing chronic obstructive pulmonary disease (COPD), according to new research looking at incidence of the disease in over 55,000 nurses in the USA, to be presented at the European Respiratory Society International Congress.
CONCLUSIONS: The high prevalence of PAs, frequently associated with both brain organic lesions and drug side effects, highlights the clinical interest of pupillary surveillance in non-selected critically ill patients. PMID: 28932559 [PubMed]
CONCLUSIONS: Our findings suggest that statins might be safe and beneficial for patients with PH due to chronic lung diseases. However, larger RCTs with more patients and longer observational duration are needed. PMID: 28932549 [PubMed]
Publication date: Available online 23 September 2017 Source:Chemico-Biological Interactions Author(s): Ming Zhang, Jingjing Tang, Yali Li, Yingying Xie, Hu Shan, Mingxia Chen, Jie Zhang, Xia Yang, Qiuhong Zhang, Xudong Yang Curcumin has been widely used to treat numerous diseases due to its antioxidant property. The aim of the present study is to investigate the effect of curcumin on skeletal muscle mitochondria in chronic obstructive pulmonary disease (COPD) and its underlying mechanism. The rat model of COPD was established by cigarette smoke exposure combined with intratracheal administration of lipopolysaccharide. Air...
CONCLUSIONS: Genetic variants in HHIP were related with FEV1/FVC in COPD. Significant relationships between risk alleles and risk genotypes and FEV1/FVC in COPD were also identified. PMID: 28929109 [PubMed - in process]
Use of steroid inhalers for asthma and chronic obstructive pulmonary disease increases the risk of mycobacterial infections, according to a study published in the European Respiratory Journal.
Authors: Bouharaoua S, Combe-Cayla P, Rakotonirina S, Leymarie M, Pignier C, Dupuis M, Didier A PMID: 28927678 [PubMed - as supplied by publisher]
Abstract PurposeThe aim of this prospective observational study was to evaluate the relationship between changes in pulmonary artery systolic pressure (ΔPASP) and both severity of community‐acquired pneumonia (CAP) and changes in peripheral blood oxygen partial pressure (PaO2). Materials and MethodsSeventy‐five consecutive adult patients hospitalized for treatment of CAP were recruited in this single‐center cohort study. Doppler echocardiographic measurement of PASP was performed by 2 staff cardiologists. Follow‐up assessment was performed within 2 to 4 weeks of ending antibiotic treatment at radiographic res...
Publication date: Available online 22 September 2017 Source:Journal of Food and Drug Analysis Author(s): Tufan Güray, Muzaffer Tunçel, Ulku Dilek Uysal Indacaterol is a new inhaled ultra-long acting β 2 -agonist. It has been recently approved in the European Union for the treatment of chronic obstructive pulmonary disease. This paper reports, for the first time, a method for the determination and validation of Indacaterol (IND) using an internal standard in capsules. Capillary electrophoretic separation was performed on an uncoated fused-silica capillary (50 cm effective length, 75 μm i.d.) a...
Heightened arterial stiffness is a marker of cardiovascular risk and is elevated in chronic obstructive pulmonary disease (COPD). Physical activity has been shown to reduce arterial stiffness, and our previous work has shown that arterial stiffness is related to physical activity and exercise tolerance in COPD. The purpose of this study was to evaluate whether baseline physical activity and exercise tolerance influence the cardiovascular benefits associated with standard COPD outpatient pulmonary rehabilitation (PR).
Conclusion Inactivation of GSK-3β up-regulates skeletal muscle mitochondrial metabolism and increases expression levels of PGC-1 signaling constituents. In vivo, GSK-3β KO protects against inactivity-induced reductions in muscle metabolic gene expression.