Comparison of Melatonin and Sertraline Therapies on Tinnitus: A Randomized Clinical Trial

In this study, we aimed to compare the effcacy of melatonin and sertraline in treating tinnitus for the frst time.Methods:In this clinical trial, 70 patients with tinnitus according to inclusion and exclusion criteria were included and randomly divided into twogroups: melatonin group, taking melatonin 3 mg once daily and sertraline group taking sertraline 50 mg once daily, all treating for 3 months. Before and after treatments, every patient received Tinnitus Handicap Inventory (THI) questionnaire and severity of tinnitus was assessed, and dataanalysis was performed.Results:Before treatments, the mean of THI score for melatonin andsertraline groups were 45.02± 17.67 and 44.85± 20.57, respectively. There was no signifcant difference between both groups THI score (P= 0.23). After 3 months, the mean of THI scores for melatonin and sertraline groups were 30.29± 19.62 and 36.96± 25.03, respectively which themean of THI scores in two groups was decreased signifcantly (P
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research

Related Links:

ConclusionSymptoms of eighth nerve dysfunction are present in over half of patients with GCA. Recovery with steroids was predicted by concurrence with headache in terms of both timing and location. It appears that eighth nerve involvement, especially acute hearing loss, is a not infrequent feature of GCA and often responds well to steroid therapy. Clinicians should enquire about these symptoms when evaluating a patient for possible GCA.Key Points• Deafness is a frequent presenting feature of giant cell arteritis.• Vertigo, tinnitus and loss of balance are also often reported by GCA sufferers.• Steroid therap...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionThis study showed that FS might be associated with MS. Injectable or oral agents are not related to the signs and symptoms of FS. Further studies are needed to validate this association.Relevance of the article for predictive, preventive, and personalized medicineFS is common among MS patients. Being aware of this incidence that might impair the life quality of MS patients is useful to predict the comorbidity and develop preventive strategies and applying personalized treatment options and procedures.
Source: EPMA Journal - Category: International Medicine & Public Health Source Type: research
In this study we addressed this issue, testing the hypothesis that limbic changes in tinnitus relate to both disease-related distress as well as co-morbid psychopathology. We obtained high-resolution structural magnetic resonance imaging (MRI) scans from a total of 125 subjects: 59 patients with bilateral chronic tinnitus (29 with a co-morbid psychiatric condition, 30 without), 40 healthy controls and 26 psychiatric controls with depression/anxiety disorders (without tinnitus). Voxel-based morphometry with the CAT12 software package was used to analyse data. First, we analysed data based on a 2 × 2 factorial desi...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This study aimed to investigate the influence of treatment with a cochlear implant (CI) on HRQoL, tinnitus distress, psychological comorbidities, and audiological parameters in SSD patients. METHODS: This retrospective study included 20 patients with postlingually acquired SSD (13 women, 7 men, mean age 57.0 years). Data on HRQoL were collected with the Nijmegen Cochlear Implant Questionnaire (NCIQ) and the Medical Outcome Study Short Form 36 Survey (SF-36). Tinnitus distress was assessed with the Tinnitus Questionnaire (TQ), psychological comorbidities were evaluated with validated questionnai...
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Conclusion: HIV affects all stages of auditory perception in a way similar to accelerated aging of the auditory system. And we postulate that synaptic loss may be the first step, followed by cochlear damage and central pathology as the virus remains present in all the structures of the auditory pathway causing local inflammation and degeneration. Evaluation of hearing function among all patients diagnosed with HIV infection seems to be an accepted approach; it should include OAE testing, pure tone and speech audiometry, speech-in-noise tests and ABR measurements.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Laryngo-Rhino-Otol 2019; 98: 532-533 DOI: 10.1055/a-0898-8662Dziendziel B et al. Prevalence and severity of tinnitus in Polish otosclerosis patients qualified for stapes surgery. Eur Arch Otorhinolaryngol 2019; doi: 10.1007/s00405–019–05317–8 Polnische Wissenschaftler beurteilten Prävalenz und Schwere eines Tinnitus bei einer Gruppe von für eine Stapesoperation geeigneten Patienten mit Otosklerose. Ein sekundäres Ziel war es, den Zusammenhang zwischen der Schwere des Tinnitus und der Hörschwelle zu bestimmen. [...] © Georg Thieme Verlag KG Stuttga...
Source: Laryngo- Rhino- Otologie - Category: ENT & OMF Authors: Tags: Referiert & Diskutiert Source Type: research
CONCLUSION: An evidence-based approach to the investigation of asymmetric hearing loss and tinnitus in the elderly patient can be used to formulate guidelines for the rational use of magnetic resonance imaging in this population. PMID: 31366414 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
Publication date: Available online 27 June 2019Source: Journal of Acupuncture and Meridian StudiesAuthor(s): Wa Cai, Ai-Wen Chen, Lei Ding, Wei-Dong ShenAbstractPrevious studies have confirmed the efficacy of acupuncture treatment for tinnitus. However, no relevant studies of the exact mechanism of acupuncture efficacy on tinnitus have been published. Enrolled participants with left-sided tinnitus received acupuncture treatment at TE3 and TE5. The acupuncture session lasted for 30 minutes. The infrared thermography (IRT) test of each participant's bilateral aural regions and visual analog scale scores were taken befor...
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
Abstract Chronic tinnitus, a symptom of high prevalence, is a persistent hearing sensation in the absence of an external sound source. Recent electrophysiological studies indicate that tinnitus generation is to a high degree the result of maladaptive plasticity in the central auditory pathway. The pitch of the tinnitus sensation can be assessed by performing a pitch matching procedure. In the most frequent "tonal tinnitus" type pure tones are used as test stimuli. However, in the case of tonal tinnitus not a single malfunctioning neuron, but rather a population of neighbouring neurons is involved in the ...
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research
No abstract available
Source: The Hearing Journal - Category: Audiology Tags: Hearing Matters Source Type: research
More News: Chemistry | Clinical Trials | Complementary Medicine | Diets | Herbs | International Medicine & Public Health | Melatonin | Nutrition | Sertraline | Study | Tinnitus | Zoloft