Comparison of Melatonin and Sertraline Therapies on Tinnitus: A Randomized Clinical Trial
In this study, we aimed to compare the effcacy of melatonin and sertraline in treating tinnitus for the frst time.Methods:In this clinical trial, 70 patients with tinnitus according to inclusion and exclusion criteria were included and randomly divided into twogroups: melatonin group, taking melatonin 3 mg once daily and sertraline group taking sertraline 50 mg once daily, all treating for 3 months. Before and after treatments, every patient received Tinnitus Handicap Inventory (THI) questionnaire and severity of tinnitus was assessed, and dataanalysis was performed.Results:Before treatments, the mean of THI score for melatonin andsertraline groups were 45.02± 17.67 and 44.85± 20.57, respectively. There was no signifcant difference between both groups THI score (P= 0.23). After 3 months, the mean of THI scores for melatonin and sertraline groups were 30.29± 19.62 and 36.96± 25.03, respectively which themean of THI scores in two groups was decreased signifcantly (P
An amendment to this paper has been published and can be accessed via the original article.
Rapid review question: What are the medium- and long-term health sequelae of COVID-19 infection among survivors? In brief: General health sequelae • Symptoms commonly reported among recovered COVID-19 patients two to eight weeks after the onset of symptoms (or a positive COVID-19 test) include: fatigue, shortness of breath, muscle or joint pain, chest pain, cough, and insomnia and/or sleep disorders.(1-6) • A study of 202 confirmed COVID -19 patients with mild symptoms, found altered sense of smell or taste occurred in 18.6% of patients, feelings of being tired in 13.1%, problems breathing in 10.4% and muscle or ...
Conditions: Tinnitus; Tinnitus, Subjective Interventions: Other: transcranial Random Noise Stimulation (tRNS) with acoustic stimulation (AS); Other: transcranial Random Noise Stimulation (tRNS) without acoustic stimulation (AS) Sponsor: University of Zurich Not yet recruiting
Conclusion: We have shown that tinnitus is associated with speech intelligibility in noise, but it is a small effect, only found in people with co-occurring hearing loss.
Conclusions: Endoscopically assisted stapes surgery represents a safe alternative to traditional microscopic techniques, with similar morbidity and audiological outcomes.
Conclusions: Central auditory speech processing in the presence of both vascular burden and pure-tone average may not be related to brain volumes and white matter microstructure. Longitudinal follow-up is needed to explore these relationships thoroughly.
Conclusion: We report the first case of possible steroid-induced necrosis of the long process of the incus. Owing to its tenuous blood supply, the incus may be predisposed to steroid-induced osteonecrosis similar to that of the femoral head.
Conclusions: CI provides greater gains in functional hearing for patients with MD compared with age-matched controls. Patients with active MD seem to perform better with respect to SRS following CI than patients with inactive status.
Conclusions: Tinnitus self-report is inherently variable but can converge on reliable values with extended testing. Repeated, self-directed tinnitus assessments may have implications for identifying malingerers. Further, these findings suggest that extending the baseline phase of tinnitus characterizations will increase the statistical power for future studies focused on tinnitus interventions.
To celebrate the 250th anniversary of the birth of the great classical composer, Ludwig van Beethoven (1770–1827), we point out how his hearing loss affected him and how the primitive hearing aids at that time helped mitigate his hearing loss. From the age of 26, Beethoven began to suffer from a fluctuating, progressive hearing loss (“my hearing grew worse and worse”), This started in his left ear (“in my left ear, with which this illness of my ears had started”), where he had difficulty hearing higher pitched tones (“I don’t hear the high notes of the instruments and voices”...