The novel 19G endobronchial USS (EBUS) needle samples processed as tissue “core biopsies” facilitate PD‐L1 and other biomarker testing in lung cancer specimens: case report and the view point from the Respiratory Physician and the Pathologist

We report a case of metastatic adenocarcinoma with the only accessible site of biopsy being a hilar lymph node. Using the 19G core‐biopsy needle and processing the microbiopsy samples in formalin provided more material for predictive biomarker testing, including PD‐L1 immunohistochemistry, when traditional processing was inadequate. This case highlights the need for close multidisciplinary discussions between the pathologist and the respiratory physician regarding emerging biomarkers and novel biopsy techniques to obtain maximum utility of the tools and avoid repeated procedures for the patient. The novel 19G EBUS needle samples could be maximally utilized for Programmed Death Ligand (PD‐L1) testing when processed in formalin as "micro core‐biopsies".
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research