Organoid technology for brain and therapeutics research.

Organoid technology for brain and therapeutics research.
CNS Neurosci Ther. 2017 Oct;23(10):771-778
Authors: Wang Z, Wang SN, Xu TY, Miao ZW, Su DF, Miao CY
Abstract
Brain is one of the most complex organs in human. The current brain research is mainly based on the animal models and traditional cell culture. However, the inherent species differences between humans and animals as well as the gap between organ level and cell level make it difficult to study human brain development and associated disorders through traditional technologies. Recently, the brain organoids derived from pluripotent stem cells have been reported to recapitulate many key features of human brain in vivo, for example recapitulating the zone of putative outer radial glia cells. Brain organoids offer a new platform for scientists to study brain development, neurological diseases, drug discovery and personalized medicine, regenerative medicine, and so on. Here, we discuss the progress, applications, advantages, limitations, and prospects of brain organoid technology in neurosciences and related therapeutics.
PMID: 28884977 [PubMed - in process]

Source: CNS Neuroscience and Therapeutics - September 10, 2017 Category: Neuroscience Authors: Wang Z, Wang SN, Xu TY, Miao ZW, Su DF, Miao CY Tags: CNS Neurosci Ther Source Type: research