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Respiratory tract infections in young children linked to asthma and worse lung function

(European Lung Foundation) Respiratory tract infections in young children are linked to an increased risk of asthma and worse lung function in later life, according to new research to be presented at the European Respiratory Society International Congress. An international study of 154,942 European children found a 1.5- to four-fold increased risk.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Abstract Long chain-free fatty acids (LCFFAs) play pivotal roles in various physiological functions, like inflammation, insulin resistance, hypertension, immune cell behavior and other biological activities. However, the detection is obstructed by the low contents, structural diversity, high structural similarity, and matrix interference. Herein, a fast cholamine-derivatization, within 1 min at room temperature, coupled with liquid chromatography-mass spectrometry (LC-MS) approach was developed to determine LCFFAs in complex samples. After derivatization, the ionization and separation efficiency were signific...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract Obstructive airways inflammatory diseases sometimes show overlapping symptoms that hinder their early and correct diagnosis. Current clinical tests are tedious and are of inadequate specificity in special population such as the elderly and children. Therefore, we are developing tandem mass spectrometric (MS/MS) methods for targeted analysis of urine biomarkers. Recently, proton-nuclear magnetic resonance ((1)H-NMR) analysis proposed 50 urinary metabolites as potential diagnostic biomarkers among asthma and chronic obstructive pulmonary disease (COPD) patients. Metabolites are divided into 3 groups based o...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Boston Scientific (NYSE:BSX) today released 3-year follow-up cohort results from the post-FDA approved PAS2 clinical trial of its Alair system designed for bronchial thermoplasty to treat severe persistent asthma, touting reduced severe asthma attacks, hospitalizations and ER visits. Results from the trial were recently published in the European Respiratory Journal, the Marlborough, Mass.-based company said. The PAS2 trial is an open-label study which enrolled patients at 27 North American centers, with 95% of the recruited patients considered severe asthmatics. Boston Scientific said that data from the cohort co...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Respiratory Boston Scientific Source Type: news
Pneumonitis is a condition caused by inhaling certain substances, leading to an allergic reaction in the lungs. Learn about the symptoms and treatments.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news
CONCLUSION AND IMPLICATIONSGα12 plays a crucial role in HASMC contraction via RhoA‐dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. Taken together, these findings provide alternative approaches to the clinical management of airway obstruction in asthma.
Source: British Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: RESEARCH PAPER Source Type: research
-- If you have food allergies and plan to eat out, it's important to remember that the beverages you drink may also be a source of the sniffles or more serious reactions. The American Academy of Food Allergy Asthma&Immunology offers these...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
(Michigan Medicine - University of Michigan) Most parents are sure schools would be able to provide basic first aid but are less confident about a school's ability to respond to more complex health situations, such as an asthma attack or mental health problem.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
BackgroundGenetic and epidemiologic evidence suggests that in horses, as in other species, different manifestations of hypersensitivity may occur together. HypothesisHorses affected with insect bite hypersensitivity (IBH) show airway hyperreactivity (AH) to inhaled histamine, even in the absence of overt clinical signs of equine asthma (EA). AnimalsTwenty‐two healthy controls (group C), 24 horses suffering from IBH alone (group IBH), and 23 horses suffering from IBH and EA (group IBH/EA). MethodsThe clinical histories were assessed using 2 standardized questionnaires, the Horse Owner Assessed Respiratory Signs Index (HOA...
Source: Journal of Veterinary Internal Medicine - Category: Veterinary Research Authors: Tags: Standard Article Source Type: research
ConclusionsOverall, the evidence to support the cost‐effectiveness of AIT is limited and of low methodological quality, but suggests that AIT may be cost‐effective for people with allergic rhinitis with or without asthma and in high‐risk subgroups for venom allergy. We were unable to draw any conclusions on the cost‐effectiveness of AIT for food allergy.
Source: Allergy - Category: Allergy & Immunology Authors: Tags: REVIEW ARTICLE Source Type: research
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