Cytoplasmic domain of tissue factor promotes liver fibrosis in mice.
CONCLUSION: Tissue factor cytoplasmic domain is involved in TF-PAR-2 signalling initiating hepatic fibrosis and is a potential therapeutic target, as its deletion would not impact coagulation.
PMID: 28883694 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Knight V, Lourensz D, Tchongue J, Correia J, Tipping P, Sievert W Tags: World J Gastroenterol Source Type: research