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Acromegaly treatment in Romania. How close are we to disease control?

Acromegaly treatment in Romania. How close are we to disease control? Endokrynol Pol. 2017 Sep 07;: Authors: Niculescu DA, Baciu IF, Capatina C, Galoiu SA, Gheorghiu ML, Radian S, Trifanescu RA, Caragheorgheopol A, Coculescu M, Poiana C Abstract INTRODUCTION: In Romania no nationwide data for acromegaly treatment and control rate are available. Our objective was to assess the acromegaly control rate in a tertiary referral center which covers an important part of Romanian territory and population of patients with acromegaly. MATERIAL AND METHODS: We reviewed the records of all 164 patients (49 males and 115 female; median age 55 (47, 63.5) years) with newly or previously diagnosed acromegaly who have been assessed at least once in our tertiary referral center between January 1st, 2012 and March 31st, 2016. This sample represents 13.6% of the total expected 1200 Romanian patients with acromegaly and covers 82.9% of counties of Romania. Control of acromegaly was defined as a random serum growth hormone (GH)
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research

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AbstractPurposeIn clinical research involving acromegalic patients na ïve to somatostatin-receptor ligands (SRLs), 19 and 31% of those receiving the SRLs octreotide LAR and pasireotide LAR, respectively, achieved GH 
Source: Pituitary - Category: Endocrinology Source Type: research
Condition:   Acromegaly Intervention:   Other: Oral manifestations Sponsor:   University Hospital, Clermont-Ferrand Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Acromegaly is associated with high morbidity and elevated mortality when not adequately treated. Surgery is the first-line treatment for most patients as it is the only one that can lead to immediate cure. In patients who are not cured by surgery, treatment is currently based on a trial-and-error approach. First-generation somatostatin receptor ligands (fg-SRL) are initiated for most patients, although approximately 25% of patients present resistance to this drug class. Some biomarkers of treatment outcome are described in the literature, with the aim of categorizing patients into different groups to indi...
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
ConclusionsKi-67, TOPO 2A, AIP and VEGF were expressed in over 70% of all somatotropinomas. Only Ki-67 and TOPO 2A expression correlated with tumour size and tumour invasiveness. PMID: 29334118 [PubMed - as supplied by publisher]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
ConclusionsActivating mutations in theABCC9 and, less commonly,KCNJ8 genes —representing the two subunits of the ATP-sensitive potassium channel—have been linked with Cantú syndrome. Interestingly, minoxidil, a well-known ATP-sensitive potassium channel agonist, can cause a similar phenotype. There is no clear explanation why activating this channel would lead to acro megaloid features or hypertrichosis. This report raises awareness for this complex condition, especially for adult or pediatric endocrinologists who might see these patients referred for evaluation of acromegaloid features or hirsutism. The...
Source: Endocrine - Category: Endocrinology Source Type: research
AbstractPurpose1) To compare the retinal, choroidal, Haller ’s layer, and Sattler’s/choriocapillaris thicknesses of untreated acromegaly patients without chiasm compression or diabetes mellitus and healthy controls. 2) To evaluate the correlations of retinal and choroidal thicknesses with serum growth hormone (GH) and insulin-like growth factor 1 (IGF) b urden.MethodsThis prospective, case-control study included 27 untreated acromegaly patients and 27 sex-matched and age-matched controls. Subfoveal choroidal, Haller ’s layer and Sattler’s/choriocapillaris thicknesses were determined by enhanced-dept...
Source: Endocrine - Category: Endocrinology Source Type: research
According to a study, published in theJournal of Clinical Endocrinology& Metabolism, premenopausal women with acromegaly have worse outcomes after transsphenoidal adenomectomy.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Conclusions Patients with treatment-naïve acromegaly are at an increased risk of developing left ventricular hypertrophy, diastolic dysfunction and systolic dysfunction than the general population.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
AbstractSilent growth hormone adenomas (SGHA) are a rare entity of non-functioning pituitary neuroendocrine tumors. Diagnosis is invariably made post-operatively of a tumor immunopositive for GH (and Pit-1 in selected cases) but without clinical acromegaly. Mainly young females are affected, and tumors are often uncovered by investigation for headaches or oligoamenorrhea. Integration of clinical, pathological and biochemical data is required for proper diagnosis. Beside normal IGF-1 levels, a third of SGHAs displays elevated GH levels and some will eventually progress to acromegaly. Almost two-thirds will be mixed GH-prola...
Source: Pituitary - Category: Endocrinology Source Type: research
Abstract Air sacs are an important component of the avian respiratory system, and corresponding structures also were crucial for the evolution of sauropod dinosaur gigantism. Inferring the presence of air sacs in fossils so far is restricted to bones preserving internal pneumatic cavities and foramina as osteological correlates. We here present bone histological correlates for air sacs as a new potential identification tool for these elements of the respiratory system. The analysis of several avian and non-avian dinosaur samples revealed delicate fibres in secondary trabecular and secondary endosteal bone that in ...
Source: Biology Letters - Category: Biology Authors: Tags: Biol Lett Source Type: research
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