Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report

Publication date: November 2017 Source:Urology Case Reports, Volume 15 Author(s): Hiroki Fukuhara, Hiroshi Kakizaki, Hisashi Kaneko, Takuya Yamanobe, Masaki Ushijima, Yuya Kuboki, Norihiko Tsuchiya Urothelial carcinoma of the bladder (UCB) with glandular differentiation is a histological variant (HV) that is more likely to have positive extravesical tumors or nodes than those in pure UCB. Cisplatin-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) is more effective for pure UCB; however, few reports are available on second-line chemotherapy for recurrence of UCB with HV. Here we report a 65-year-old Japanese male diagnosed with local recurrence UCB with HV after NAC + RC who safely achieved complete response with paclitaxel, carboplatin, and gemcitabine combination chemotherapy.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research