Resuscitation Ventilation with CCSV – Experience the Innovation at ERC Congress in Freiburg

(Hamburg) – Medical device manufacturer WEINMANN Emergency has developed a ventilation mode specially designed for resuscitation, Chest Compression Synchronized Ventilation (CCSV). CCSV applies a pressure-controlled mechanical breath synchronously with each chest compression, avoiding the disadvantages of conventional ventilation forms during resuscitation, while simultaneously improving gas exchange and hemodynamics. For the first time, mechanical breaths with a regulated peak pressure are delivered synchronously with chest compressions – a revolution that could replace volume-controlled ventilation as the gold standard for resuscitation! Be curious and learn more about CCSV at this year´s ERC Congress, 28th to 30th September, in Freiburg. With CCSV, WEINMANN Emergency introduces a ventilation mode for the emergency medical device MEDUMAT Standard² that can be fully integrated into today's resuscitation process and is compatible with existing automatic chest compression devices. During chest compression, the heart and the pulmonary vessels in the lung are compressed, which also results in gas volume escaping from the lung below. Surrounded by soft tissue, the heart can thus compress only to a limited extent. The CCSV ventilation mode revolutionizes this decades-old procedure. CCSV modifies the principle of resuscitation as follows: The synchronized stroke causes the thoracic pressure to additionally increase during the compression phase. ...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Patient Care Industry News Source Type: news

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The objective of this review is to provide a broad overview on current strategies for brain drug delivery and related subjects from the past five years. It is hoped that this review could inspire readers to discover possible approaches to deliver drugs into the brain. After an initial overview of the BBB structure and function in both healthy and pathological conditions, this review re-visits, according to recent publications, some questions that are controversial, such as whether nanoparticles by themselves could cross the BBB and whether drugs are specifically transferred to the brain by actively targeted nanoparticles. ...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
Conclusion: For the first time in vivo, enhancement of both GOLD metabolic imaging techniques has been demonstrated following intravenous O-PFC+hyperoxia to identify ischaemic penumbra. We have also presented preliminary evidence of the potential therapeutic benefit offered by O-PFC. These unique theranostic applications would enable treatment based on metabolic status of the brain tissue, independent of time from stroke onset, leading to increased uptake and safer use of currently available treatment options.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusion: CCR2-dependent monocytes/macrophages are a double-edged sword; they worsen acute brain injury, but are essential for neurological recovery by promoting anti-inflammatory macrophage polarization.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Modulation of the inflammatory microenvironment after stroke opens a new avenue for the development of novel neurorestorative therapies in stroke. Understanding the spatio-temporal profile of (neuro-)inflammatory imaging biomarkers in detail thereby represents a crucial factor in the development and application of immunomodulatory therapies. The early integration of quantitative molecular imaging biomarkers in stroke drug development may provide key information about (i) early diagnosis and follow-up, (ii) spatio-temporal drug-target engagement (pharmacodynamic biomarker), (iii) differentiation of responders and non-respon...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
In this article the authors discuss in broad strokes the work of two theorists, namely Nigerian sociologist Oy èrónkẹ́ Oyěwùmí and Argentinian philosopher Maria Lugones to argue that a specific logic of sexualisation accompanied, permeated and colou...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Conclusion: The ST2 is associated with diastolic function and may be a predictor of clinical outcomes in incident hemodialysis patients. PMID: 29910678 [PubMed - in process]
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Conclusions: NIR fluorescence-assisted method could potentially provide new opportunities to study BBB leakage just using small amount of EBD in different pathological conditions and to test the efficacy of various therapeutic strategies to protect the BBB. PMID: 29910674 [PubMed - in process]
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Publication date: Available online 18 June 2018 Source:Journal of Cardiology Cases Author(s): Masami Takagaki, Naoko Ikeda, Hiroki Yamaguchi, Shinichi Mitsuyama, Tasuku Kadowaki, Tatsuya Nakao Although surgical left atrial (LA) volume reduction combined with mitral valve surgery and/or surgical ablation for atrial fibrillation has been reported to be effective, its long-term outcomes in the absence of mitral procedure are not well established. A 74-year-old man with two previous sternotomies—the first for pericardiectomy due to constrictive pericarditis and the second for mitral valve replacement with mechanical val...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Conclusion Bail-out intracranial stenting after unsuccessful thrombectomy is technically feasible and the associated haemorrhagic risk seems acceptable in selected patients. We suggest that bail-out intracranial stenting, is safe and effective in selected patients with LVO stroke who failed to respond to thrombectomy.
Source: Journal of Neuroradiology - Category: Radiology Source Type: research
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