Elimination of Guinea Worm Disease in Ethiopia; Current Status of the Disease's, Eradication Strategies and Challenges to the End Game.

Elimination of Guinea Worm Disease in Ethiopia; Current Status of the Disease's, Eradication Strategies and Challenges to the End Game. Ethiop Med J. 2017;55(Suppl 1):15-31 Authors: Beyene HB, Bekele A, Shifara A, Ebstie YA, Desalegn Z, Kebede Z, Mulugeta A, Deribe K, Tadesse Z, Abebe T, Kebede B, Abrha G, Jima D Abstract Dracunculiasis, also named Guinea Worm Disease (GWD), is one of the Neglected Tropical Diseases (NTDs) caused by a parasitic nematode known as Dracunculus medinensis and has been known since antiquity as 'fiery serpent' from Israelites. It is transmitted to humans via drinking contaminated water containing infective copepods. Given, its feasibility for eradication, the Guinea Worm Eradication Program (GWEP) was launched in 1980 with the aim of eradicating the disease. Since its inception, GWEP has made an extraordinary progress in interrupting transmission. Globally, the number of reported cases reduced from 3.5 million in 20 countries in 1986 to only 22 cases in 2015 from only four countries namely South Sudan, Mali, Chad and Ethiopia. Since Mali has interrupted transmission of GWD in 2016, currently, the disease remains endemic in only three sub-Saharan African countries namely, South Sudan, Chad and Ethiopia. Each endemic country has its own national Guinea Worm Eradication Program. In Ethiopia, the Ethiopian Dracunculiasis Eradication Program (EDEP) which was established in 1993 has made remarkable move towards interruption of diseas...
Source: Ethiopian Medical Journal - Category: African Health Tags: Ethiop Med J Source Type: research

Related Links:

Authors: Sbhatu DB, Abraha HB Abstract Medicinal plants and plant remedies have been in use in Ethiopia for centuries. Studies on ethnobotany, ethnomedicine, and ethnoveterinary estimate that nearly 80% of Ethiopians use some type of medicinal plants and plant remedies. Medicinal plants are regarded as the most important and sometimes the only source of therapeutics in the country. Some 800 plant species are used as sources of medicine to treat about 300 physical and mental disorders. However, because these plant species are not adequately studied, there is a big limitation in their documentation, profiling, and ma...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Source: Therapeutics and Clinical Risk Management - Category: Drugs & Pharmacology Tags: HIV/AIDS - Research and Palliative Care Source Type: research
This study aims at detection of R. typhi in rodent fleas by conventional polymerase chain reaction (PCR). A cross sectional study ...
Source: African Journal of Microbiology Research - Category: Microbiology Source Type: research
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02751C, PaperShuvendu Saha, Modhu Sudan Maji An effective and operationally simple one-pot Br ønsted acid catalyzed cascade method is demonstrated for the synthesis of diversely functionalized carbazole frameworks starting from protecting group free 2-alkenyl indoles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
In this study, we generated a model to test available formulations based on the P. vivax MSP119 antigen. The Plasmodium berghei strains ANKA and NK65 were modified to express PvMSP119 instead of the endogenous PbMSP119. The hybrid parasites were used to challenge C57BL/6 or BALB/c mice immunized with PvMSP119-based vaccine formulations. The PvMSP119 was correctly expressed in the P. berghei hybrid mutant lines as confirmed by immunofluorescence using anti-PvMSP119 monoclonal antibodies and by Western blot. Replacement of the PbMSP119 by the PvMSP119 had no impact on asexual growth in vivo. High titers of specific antibodie...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
We present the first extensive population genetic data for Guinea worm, inves tigating mitochondrial and microsatellite variation in adult female worms from both human and non-human hosts in the four endemic countries to elucidate the origins of Chad’s current outbreak and possible host-specific differences between parasites. Genetic diversity of Chadian Guinea worms was co nsiderably higher than that of the other three countries, even after controlling for sample size through rarefaction, and demographic analyses are consistent with a large, stable parasite population. Genealogical analyses eliminate the other three...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
This report updates published (3-4) and unpublished surveillance data reported by ministries of health and describes progress toward dracunculiasis eradication during January 2016-June 2017. In 2016, a total of 25 cases were reported from three countries (Chad [16], South Sudan [six], Ethiopia [three]), compared with 22 cases reported from the same three countries and Mali in 2015 (Table 1). The 14% increase in cases from 2015 to 2016 was offset by the 25% reduction in number of countries with indigenous cases. During the first 6 months of 2017, the overall number of cases declined to eight, all in Chad, from 10 cases in t...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Publication date: 7 November 2017 Source:Journal of Theoretical Biology, Volume 432 Author(s): Lorenzo Mari, Manuela Ciddio, Renato Casagrandi, Javier Perez-Saez, Enrico Bertuzzo, Andrea Rinaldo, Susanne H. Sokolow, Giulio A. De Leo, Marino Gatto Simple models of disease propagation often disregard the effects of transmission heterogeneity on the ecological and epidemiological dynamics associated with host-parasite interactions. However, for some diseases like schistosomiasis, a widespread parasitic infection caused by Schistosoma worms, accounting for heterogeneity is crucial to both characterize long-term dynamics and e...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
This article is part of HuffPost’s Project Zero campaign, a yearlong series on neglected tropical diseases and efforts to fight them. JUBA, South Sudan ― It took days for Maker Achuil and others to slowly pull the arm-length, spaghetti-like worm out of his thigh. After a year with the white parasite inside him, Achuil screamed in pain as the grown Guinea worm emerged. A former soldier in South Sudan, which fought for decades before gaining its independence from Sudan in 2011, Achuil still shudders at the memory of the agony he felt as the worm was gradually wound around a stick. “It was like putting...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
This article reviews and summarises the imaging findings of some of the most important and frequent human parasitic diseases, including information about the parasite ’s life cycle, pathophysiology, clinical findings, diagnosis, and treatment. We include malaria, amoebiasis, toxoplasmosis, trypanosomiasis, leishmaniasis, echinococcosis, cysticercosis, clonorchiasis, schistosomiasis, fascioliasis, ascariasis, anisakiasis, dracunculiasis, and strongyloidiasis. Th e aim of this review is to help radiologists when dealing with these diseases or in cases where they are suspected.Teaching Points•Incidence of parasitic...
Source: Insights into Imaging - Category: Radiology Source Type: research
More News: African Health | Chad Health | Chemistry | Dracunculiasis (Guinea Worm Disease GWD) | Education | Endemics | Ethiopia Health | Guinea Health | Mali Health | Parasitic Diseases | Parasitology | Sudan Health | Universities & Medical Training