Predictors of outcome in children and adolescents with overactive bladder treated with parasacral transcutaneous electrical nerve stimulation

Parasacral transcutaneous electrical nerve stimulation (TENS) has emerged as an effective treatment for overactive bladder (OAB) in view of its high success rates in improving lower urinary tract symptoms and constipation, with no direct side effects. However, the clinical characteristics associated with the outcomes remain to be established.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research

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Authors: Morinaga Y, Nii K, Sakamoto K, Inoue R, Mitsutake T, Hanada H Abstract Paroxysmal sympathetic hyperactivity (PSH) is a clinical condition characterized by abnormal paroxysmal surges in sympathetic nervous system activity. PSH is known to occur after severe head injury and hypoxic encephalopathy. Cases of PSH that develop after stroke have been reported worldwide; however, PSH is not commonly reported in the field of stroke research in Japan. Some studies have suggested that gabapentin may improve the symptoms of PSH. To our knowledge, this is the first case report demonstrating the efficacy of trazodone fo...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
ConclusionThere are no differences between mirabegron and antimuscarinics in terms of patient-reported OAB symptom bother and HRQoL.Trial RegistrationClinicalTrials.gov identifier, NCT02386072.FundingAstellas Pharma Global Development, Inc.Plain Language SummaryPlain language summary available for this article.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Conclusion: Solifenacin and tolterodine yielded similar results on daily micturition frequency, daily urgency episodes, daily incontinence episodes, micturition volume per voiding, and the incidence of dry mouth. However, tolterodine can decrease the constipation rate at 12 weeks compared with solifenacin.Urol Int
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
AbstractIntroductionOveractive bladder (OAB) affects adults of all ages. The risk for medication-related adverse events (AEs) may differ between age groups, given age-related changes in pharmacokinetics and pharmacodynamics. No previous study has differentiated the risk of AEs between older and non-older adults with OAB.ObjectiveOur objective was to assess the risk of AEs and treatment discontinuations between older and non-older adults with OAB initiated on an antimuscarinic.MethodsWe searched MEDLINE (PubMed interface), Embase, SCOPUS, and Cochrane Central Register for Controlled Trials in a previous analysis in February...
Source: Drugs and Aging - Category: Geriatrics Source Type: research
DiscussionThe pathophysiological symptoms of urination and defecation in Sasang typology were systematically scrutinized, and summarized into six subscales of SUDI in this study. The SUDI would be useful for analyzing clinical symptoms of Sasang typology along with integrative collaboration of traditional Korean and Western medicine.
Source: Integrative Medicine Research - Category: Complementary Medicine Source Type: research
Abstract STUDY DESIGN: Prospective cohort study OBJECTIVES: We hypothesized that anti-muscarinic agents alter rectal compliance in SCI patients and that altered rectal compliance relates to bowel symptomatology. Our primary aim was to compare rectal compliance before and after the institution of anti-muscarinics (solifenacin and tolterodine) and an adrenoceptor agonist (mirabegron) in these patients. Additionally, we wanted to evaluate if anorectal manometry differed before and after use of anti-muscarinic agents. SETTING: Tertiary neurogastroenterology clinic, London METHODS: Thirty-five patients with suprac...
Source: Anal Sci - Category: Chemistry Authors: Tags: Spinal Cord Source Type: research
CONCLUSIONS: In this cohort of women with vulvar diseases, vitamin D levels and supplementation were not significantly different amongst women with vulvar lichen sclerosus or other non-lichenoid vulvar diseases. Furthermore, vitamin D levels are not serum biomarkers for OAB, urinary incontinence, constipation, or IBS. PMID: 30747611 [PubMed - as supplied by publisher]
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
AbstractPurposeTo examine the efficacy and safety of non-ablative vaginal erbium:YAG laser (VEL) for the treatment of overactive bladder syndrome (OAB) compared with those of two other common pharmacotherapies, namely, anticholinergics and β3-adrenoceptor agonists.MethodsFemale subjects aged 60 –69 years who presented with symptoms of OAB from 2015 to 2017 were assigned to three groups (n = 50) receiving treatment with an anticholinergic agent (4 mg fesoterodine), a β3-adrenoceptor agonist (25 mg mirabegron), or VEL (20 min/session of VEL performed thrice). The OAB symptom ...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
In this study, we aimed to compare the effects of oxybutynin on oxidative parameters in the potential target tissues of the oral and vaginal delivery. Female New Zealand white rabbits (n=12) were divided into two groups: oral delivery and vaginal delivery. The animals were sacrificed 48 h after administration and nitric oxide (NOx), thiobarbituric acid-reactive substances (TBARs), and glutathione (GSH) levels were determined spectrophotometrically in the aorta, salivary gland, and small intestine tissue samples. Vaginal delivery significantly decreased NOx levels in all tissue samples as compared to oral delivery (p
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
(Abstracted from Int Urogynecol J 2018;29:1213–1219) First-line therapy for overactive bladder (OAB) includes an anticholinergic (ACH) medication and behavioral modification. There are high rates of discontinuation with ACH because of adverse effects such as dry mouth, dry eyes, and constipation.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: UROGYNECOLOGY Source Type: research
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